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Application of Chitosan and Hyaluronan

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 481

Special Issue Editor


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Guest Editor
Centre of Experimental Medicine of Slovak Academy of Sciences, Dubravska Cesta 9, 84104 Bratislava, Slovakia
Interests: hyaluronan; reactive oxygen species; drugs; antioxidants; biopolymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to publish papers on chitosan and hyaluronan applications. Chitosan is synthesized by the alkaline N-deacetylation of chitin (β-N-acetyl-glucosamine polymer). It has several advantageous properties, such as degradability, biocompatibility, physiological inertness, absence of toxicity, remarkable affinity to proteins, hemostaticity, lack of allergenicity, and antibacterial activity. Chitosan and its derivatives have been widely used in cosmetics and medicine, including biomaterials for tissue-engineered scaffolds and tissue repair, wound dressings, and biochemical separation systems. Hyaluronan, another β-polymer, is one of the major structural components of the extracellular matrix in vertebrates, widely distributed in both prokaryotic and eukaryotic cells. Adult humans contain about 12–15 g of HA, most of which occurs in skin, vitreous body of the eye, umbilical cord, and articular joint synovial fluid. The HA biopolymer provides a wide range of pharmacological activities, including anti-inflammatory, wound-healing, tissue-regenerating, immunomodulatory, anti-cancer, anti-proliferative, anti-diabetic, anti-aging, skin repairing, and cosmetic properties.

The main topics of interest are the preparation of hyaluronan, chitosan, or their derivatives and their applications in cosmetics, the food industry, water treatments, etc. and the effects of these compounds against reactive oxygen species. For this Special Issue, high-quality research papers will be accepted along with review papers summarizing the state of the art of a specific area of this field of research.

Dr. Katarína Valachová
Guest Editor

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hyaluronan
  • chitosan
  • functionalized hyaluronan and chitosan
  • hyaluronan and chitosan derivatives
  • medicinal applications
  • polysaccharides
  • reactive oxygen species
  • tissue engineering
  • biodegradable
  • biological properties
  • medicine
  • cosmetics
  • food industry
  • water treatments

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Published Papers (1 paper)

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Research

20 pages, 4085 KiB  
Article
Assessment of Potential Toxicity of Hyaluronic Acid-Coated Magnetic Nanoparticles on Maize (Zea mays) at Early Development Stages
by Mihaela Răcuciu, Cristina-Nicoleta Precup, Maria Denisa Cocîrlea and Simona Oancea
Molecules 2025, 30(6), 1316; https://doi.org/10.3390/molecules30061316 - 14 Mar 2025
Viewed by 374
Abstract
The effectiveness of iron oxide nanoparticles in enhancing crop plant development depends on their stabilization. In this study, the effect of hyaluronic acid (HA), used both as a stabilizer for iron oxide nanoparticles (HA-MNP) and independently, was evaluated in maize seedlings. Different concentrations [...] Read more.
The effectiveness of iron oxide nanoparticles in enhancing crop plant development depends on their stabilization. In this study, the effect of hyaluronic acid (HA), used both as a stabilizer for iron oxide nanoparticles (HA-MNP) and independently, was evaluated in maize seedlings. Different concentrations of HA-MNP (0.625–7.5 mg/L) were tested alongside a 0.01% HA solution. Growth parameters, antioxidant enzyme activities (peroxidase and polyphenol oxidase), photosynthetic pigments (chlorophyll and carotenoids), phenolic content, and genotoxicity were analyzed. While HA alone led to slight decreases in seedling length, pigment content, and polyphenol levels compared to the control, it increased peroxidase activity and mitotic index. Lower concentrations of HA-MNP (below 2.5 mg/L) enhanced seedling growth, likely due to improved iron uptake, whereas higher concentrations reduced pigment and phenolic content. All HA-MNP concentrations induced genotoxic effects, which was proven by an increased mitotic index and chromosomal aberrations, indicating both positive and defensive plant responses to oxidative stress. These findings suggest a complex interaction between HA, HA-MNP, and maize seedlings, where HA concentrations play a significant role in modulating growth and stress response, while higher concentrations may induce toxicity. Full article
(This article belongs to the Special Issue Application of Chitosan and Hyaluronan)
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