Therapeutic Agents for Neurodegenerative Disorders—2nd Edition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 693
Special Issue Editor
Interests: neurotrasmitters; estrogens; neurotrophins; neurodegenerative disorders; drug discovery and development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The second edition of this Special Issue of Molecules provides a forum for the dissemination of the most recent findings on therapeutic agents for neurodegenerative diseases.
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease, as well as amyotrophic lateral sclerosis, pose extraordinary challenges for drug development. There is a significant need for therapies that prevent and/or slow the progression of these disorders. The etiology of most neurodegenerative diseases is still unknown, but several factors are thought to contribute to the neurodegenerative process, such as oxidative stress, excitotoxicity, protein aggregation, vascular dysfunction, and neuroinflammation. These processes culminate in the death of specific neuronal populations, leading to cognitive and/or motor impairments, and thus offer many potential therapeutic targets. Most current treatments for these disorders target single aspects of the disease’s pathology. However, this strategy has yet to fulfil expectations in clinical trials, and focus has now turned towards therapeutics that target the underlying neurodegeneration to ensure future treatment success. A number of these therapeutic targets also act as biomarkers and as theranostics. The focus of drug design has also shifted from the treatment of neurodegenerative diseases in the later stage of disease progression to the implementation of preventive strategies in the early stage of disease development.
We welcome the submission of research and review articles that present advances in drug discovery in the field of neurodegenerative diseases.
Dr. Andrea Kwakowsky
Guest Editor
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Keywords
- beta amyloid
- tau
- alpha-synuclein
- huntingtin
- autophagy
- neuromodulators
- neurotrophins
- natural compounds
- neuroinflammation
- vascular dysfunction
- neuronal death
- drug development
- therapeutic biomarkers
- blood–brain barrier
- small-molecule therapeutics
- theranostics
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Related Special Issue
- Therapeutic Agents for Neurodegenerative Disorders in Molecules (8 articles)
