Special Issue "Metal-Catalyzed Synthesis"

A special issue of Molbank (ISSN 1422-8599). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Prof. Dr. Bartolo Gabriele
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Guest Editor
Laboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci, 12/C, 87036 – Arcavacata di Rende (Cosenza), Italy
Interests: new syntheses of high value added molecules through catalytic assembly of simple units; innovative syntheses of heterocyclic molecules of pharmaceutical, agrochemical, or applicative interest; carbonylation chemistry; use of non-conventional solvents in organic synthesis; synthesis and semi-synthesis of bioactive compounds of pharmaceutical or agrochemical interest; synthesis of new materials for advanced applications; extraction, characterization, and evaluation of the biological activity of bioactive principles from natural matrices
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Special Issue Information

Dear Colleagues,

This Special Issue is devoted to metal-catalyzed synthesis, which is of one of the most important tools in modern synthetic organic chemistry. In fact, under the catalytic action of a metal center, stabilized by suitable ligands, different small molecules can be sequentially activated to afford complex, high-value added compounds in one synthetic step. Although enormous progress has been made in this field during the last few decades, this kind of chemistry is still very attractive and important, and will continue to attract the interest of chemists, both in academia and industry around the world.

Prof. Dr. Bartolo Gabriele
Guest Editor

Manuscript Submission Information

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Keywords

  • catalysis
  • heterogeneous catalysis
  • homogeneous catalysis
  • metal-catalyzed reactions
  • organic synthesis promoted by metal catalysts

Published Papers (4 papers)

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Research

Open AccessShort Note
2′-Chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine
Molbank 2019, 2019(1), M1040; https://doi.org/10.3390/M1040 - 22 Dec 2018
Abstract
The compound 2′-chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine was obtained with a good yield by the reaction of 2-chloro-4-(1-methyl-1H-imidazol-2-yl)pyridine with (2-chloropyridin-4-yl)boronic acid and structurally characterized by nuclear magnetic resonance (1H-NMR and 13C-NMR), thin-layer chromatography–mass spectrometry (TLC–MS), HPLC, gas chromatography–mass spectrometry (GC–MS), [...] Read more.
The compound 2′-chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine was obtained with a good yield by the reaction of 2-chloro-4-(1-methyl-1H-imidazol-2-yl)pyridine with (2-chloropyridin-4-yl)boronic acid and structurally characterized by nuclear magnetic resonance (1H-NMR and 13C-NMR), thin-layer chromatography–mass spectrometry (TLC–MS), HPLC, gas chromatography–mass spectrometry (GC–MS), and elemental analysis. The functionalization of the pyridine was achieved by the palladium-catalyzed Suzuki–Miyaura carbon–carbon cross-coupling reaction that afforded the target compound. Full article
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
Open AccessShort Note
5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline
Molbank 2019, 2019(1), M1038; https://doi.org/10.3390/M1038 - 20 Dec 2018
Abstract
The title quinoline derivative, 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline, was synthesized in a common three-step procedure from 5-chloro-8-hydroxyquinoline using O-propargylation reaction/copper-catalyzed 1,3-dipolar cycloaddition sequence. The structure of the compound was fully characterized by FT-IR, 1H- and 13C-NMR, GC-MS, and elemental analysis. Its [...] Read more.
The title quinoline derivative, 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline, was synthesized in a common three-step procedure from 5-chloro-8-hydroxyquinoline using O-propargylation reaction/copper-catalyzed 1,3-dipolar cycloaddition sequence. The structure of the compound was fully characterized by FT-IR, 1H- and 13C-NMR, GC-MS, and elemental analysis. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the Molinspiration Cheminformatics software. The hybrid obtained could be an interesting model for antifungal bio-essays or a suitable precursor in the synthesis of more complex triazolyl-quinoline hybrids, potential pharmacological agents. Full article
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
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Open AccessFeature PaperShort Note
(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one
Molbank 2018, 2018(3), M1017; https://doi.org/10.3390/M1017 - 31 Aug 2018
Cited by 1
Abstract
(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one has been synthesized for the first time by the enantiospecific oxidative carbonylation of commercially available (S)-2-amino-3-methyl-1,1-diphenylbutan-1-ol. The cyclocarbonylation reaction was carried out at 100 °C in 1,2-dimethoxyethane (DME) as the solvent for 15 h, under 20 atm of [...] Read more.
(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one has been synthesized for the first time by the enantiospecific oxidative carbonylation of commercially available (S)-2-amino-3-methyl-1,1-diphenylbutan-1-ol. The cyclocarbonylation reaction was carried out at 100 °C in 1,2-dimethoxyethane (DME) as the solvent for 15 h, under 20 atm of a 4:1 mixture of CO–air and in the presence of the catalytic system PdI2/KI (substrate:KI:PdI2 molar ratio = 100:10:1), to give the oxazolidinone derivative in 81% isolated yield. Full article
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
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Open AccessCommunication
Gold-Catalyzed Synthesis of 2-Sulfenylspiroindolenines via Spirocyclizations
Molbank 2018, 2018(1), M985; https://doi.org/10.3390/M985 - 23 Feb 2018
Cited by 2
Abstract
2-Phenylsulfenyl-N-propargyl tryptamines have been prepared by electrophilic sulfuration of the corresponding tryptamines. These compounds undergo gold-catalyzed spirocyclizations to the corresponding 2-phenylthiospiroindolenines in good yields. The compounds were analyzed by NMR experiments, infrared, mass spectra and X-ray diffraction. This method provides a [...] Read more.
2-Phenylsulfenyl-N-propargyl tryptamines have been prepared by electrophilic sulfuration of the corresponding tryptamines. These compounds undergo gold-catalyzed spirocyclizations to the corresponding 2-phenylthiospiroindolenines in good yields. The compounds were analyzed by NMR experiments, infrared, mass spectra and X-ray diffraction. This method provides a new efficient entry to the synthesis of 2-sulfenyl spiroindolic compounds. Full article
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
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