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Short Note

Naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate

1
Engineering Laboratory of Organometallic, Molecular Materials and Environment (LIMOME), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
2
Team of Organic Chemistry and Valorization of Natural Substances, Faculty of Sciences, Ibn Zohr University, Agadir 80060, Morocco
3
City of Innovation, Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
*
Author to whom correspondence should be addressed.
Academic Editor: Bartolo Gabriele
Molbank 2021, 2021(4), M1285; https://doi.org/10.3390/M1285
Received: 18 August 2021 / Revised: 28 September 2021 / Accepted: 1 October 2021 / Published: 4 October 2021
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
We have previously published new biheterocyclic phospohonic α-amino esters of the 1,2,3-triazole-benzimidazole and 1,2,3-triazole-carbazole type. The aim of the present paper was to describe a new phosponic aminoester bearing a triazole ring substituted in position 5 by an ester group. Thus, according to the same catalytic process used previously, the compound naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate was synthesized with an excellent yield and high regioselectivity via the copper (I)-catalyzed alkyne–azide cycloaddition reaction (CuAAC), using diethyl (α-azido(benzamido)methyl)phosphonate (1) as a dipole and 2- naphthyl propiolate as a dipolarophile (2). The structure of the new compound was fully characterized by 1D (31P, 1H-, 13C-) and 2D (1H-1H and 1H-, 13C-) NMR spectroscopy, IR, and HRMS. View Full-Text
Keywords: triazole; α-amino phosphonic ester; 1,3-dipolar cycloaddition; click chemistry; 1D and 2D NMR; HRMS triazole; α-amino phosphonic ester; 1,3-dipolar cycloaddition; click chemistry; 1D and 2D NMR; HRMS
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MDPI and ACS Style

Fall, S.A.K.; Hajib, S.; Karai, O.; Boukhssas, S.; Aouine, Y.; Akhazzane, M.; Labriti, B.; Faraj, H.; Alami, A. Naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate. Molbank 2021, 2021, M1285. https://doi.org/10.3390/M1285

AMA Style

Fall SAK, Hajib S, Karai O, Boukhssas S, Aouine Y, Akhazzane M, Labriti B, Faraj H, Alami A. Naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate. Molbank. 2021; 2021(4):M1285. https://doi.org/10.3390/M1285

Chicago/Turabian Style

Fall, Serigne A.K., Sara Hajib, Oumaima Karai, Salaheddine Boukhssas, Younas Aouine, Mohamed Akhazzane, Brahim Labriti, Hassane Faraj, and Anouar Alami. 2021. "Naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate" Molbank 2021, no. 4: M1285. https://doi.org/10.3390/M1285

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