Next Article in Journal
5-Amino-3-(diethylamino)-5H-benzo[4,5]imidazo[1,2-b][1,2,4,6]thiatriazine 1,1-Dioxide
Next Article in Special Issue
5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline
Previous Article in Journal
(1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one
Previous Article in Special Issue
Gold-Catalyzed Synthesis of 2-Sulfenylspiroindolenines via Spirocyclizations
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molbank
Volume 2018
Issue 3
10.3390/M1017
molbank-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Short Note

(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one

by
Raffaella Mancuso
1,*,
Rossana Miliè
1,
Ida Ziccarelli
1,
Mariangela Novello
1,
Nicola Della Ca’
2 and
Bartolo Gabriele
1,*
1
Laboratory of Industrial and Synthetic Organic Chemistry, Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci 12/C, 87036 Arcavacata di Rende (CS), Italy
2
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy
*
Authors to whom correspondence should be addressed.
Molbank 2018, 2018(3), M1017; https://doi.org/10.3390/M1017
Submission received: 27 July 2018 / Revised: 22 August 2018 / Accepted: 27 August 2018 / Published: 31 August 2018
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
Browse Figures
Versions Notes

Abstract

(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one has been synthesized for the first time by the enantiospecific oxidative carbonylation of commercially available (S)-2-amino-3-methyl-1,1-diphenylbutan-1-ol. The cyclocarbonylation reaction was carried out at 100 °C in 1,2-dimethoxyethane (DME) as the solvent for 15 h, under 20 atm of a 4:1 mixture of CO–air and in the presence of the catalytic system PdI2/KI (substrate:KI:PdI2 molar ratio = 100:10:1), to give the oxazolidinone derivative in 81% isolated yield.
Keywords: β-amino alcohols; carbonylation; cyclocarbonylation; oxazolidinones; palladium β-amino alcohols; carbonylation; cyclocarbonylation; oxazolidinones; palladium
Graphical Abstract

Share and Cite

MDPI and ACS Style

Mancuso, R.; Miliè, R.; Ziccarelli, I.; Novello, M.; Della Ca’, N.; Gabriele, B. (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one. Molbank 2018, 2018, M1017. https://doi.org/10.3390/M1017

AMA Style

Mancuso R, Miliè R, Ziccarelli I, Novello M, Della Ca’ N, Gabriele B. (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one. Molbank. 2018; 2018(3):M1017. https://doi.org/10.3390/M1017

Chicago/Turabian Style

Mancuso, Raffaella, Rossana Miliè, Ida Ziccarelli, Mariangela Novello, Nicola Della Ca’, and Bartolo Gabriele. 2018. "(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one" Molbank 2018, no. 3: M1017. https://doi.org/10.3390/M1017

APA Style

Mancuso, R., Miliè, R., Ziccarelli, I., Novello, M., Della Ca’, N., & Gabriele, B. (2018). (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one. Molbank, 2018(3), M1017. https://doi.org/10.3390/M1017

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop