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Open AccessFeature PaperShort Note

(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one

1
Laboratory of Industrial and Synthetic Organic Chemistry, Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci 12/C, 87036 Arcavacata di Rende (CS), Italy
2
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy
*
Authors to whom correspondence should be addressed.
Molbank 2018, 2018(3), M1017; https://doi.org/10.3390/M1017
Received: 27 July 2018 / Revised: 22 August 2018 / Accepted: 27 August 2018 / Published: 31 August 2018
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one has been synthesized for the first time by the enantiospecific oxidative carbonylation of commercially available (S)-2-amino-3-methyl-1,1-diphenylbutan-1-ol. The cyclocarbonylation reaction was carried out at 100 °C in 1,2-dimethoxyethane (DME) as the solvent for 15 h, under 20 atm of a 4:1 mixture of CO–air and in the presence of the catalytic system PdI2/KI (substrate:KI:PdI2 molar ratio = 100:10:1), to give the oxazolidinone derivative in 81% isolated yield. View Full-Text
Keywords: β-amino alcohols; carbonylation; cyclocarbonylation; oxazolidinones; palladium β-amino alcohols; carbonylation; cyclocarbonylation; oxazolidinones; palladium
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MDPI and ACS Style

Mancuso, R.; Miliè, R.; Ziccarelli, I.; Novello, M.; Della Ca’, N.; Gabriele, B. (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one. Molbank 2018, 2018, M1017.

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