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Open AccessShort Note

5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline

Laboratorio de Química Orgánica y Biomolecular, CMN, Parque Tecnológico Guatiguará, Km 2 vía refugio, Universidad Industrial de Santander, Piedecuesta A.A. 681011, Colombia
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Author to whom correspondence should be addressed.
Academic Editor: Gabriele Bartolo
Molbank 2019, 2019(1), M1038; https://doi.org/10.3390/M1038
Received: 1 December 2018 / Revised: 16 December 2018 / Accepted: 18 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
The title quinoline derivative, 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline, was synthesized in a common three-step procedure from 5-chloro-8-hydroxyquinoline using O-propargylation reaction/copper-catalyzed 1,3-dipolar cycloaddition sequence. The structure of the compound was fully characterized by FT-IR, 1H- and 13C-NMR, GC-MS, and elemental analysis. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the Molinspiration Cheminformatics software. The hybrid obtained could be an interesting model for antifungal bio-essays or a suitable precursor in the synthesis of more complex triazolyl-quinoline hybrids, potential pharmacological agents. View Full-Text
Keywords: 4-chloro-8-hydroxyquinoline; triazoles; conjugated triazolyl-quinoline hybrid; CuAAC; Lipinski’ descriptors 4-chloro-8-hydroxyquinoline; triazoles; conjugated triazolyl-quinoline hybrid; CuAAC; Lipinski’ descriptors
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MDPI and ACS Style

Luna Parada, L.K.; Kouznetsov, V.V. 5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline. Molbank 2019, 2019, M1038.

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