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Molbank 2019, 2019(1), M1038; https://doi.org/10.3390/M1038

5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline

Laboratorio de Química Orgánica y Biomolecular, CMN, Parque Tecnológico Guatiguará, Km 2 vía refugio, Universidad Industrial de Santander, Piedecuesta A.A. 681011, Colombia
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Academic Editor: Gabriele Bartolo
Received: 1 December 2018 / Revised: 16 December 2018 / Accepted: 18 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
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Abstract

The title quinoline derivative, 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline, was synthesized in a common three-step procedure from 5-chloro-8-hydroxyquinoline using O-propargylation reaction/copper-catalyzed 1,3-dipolar cycloaddition sequence. The structure of the compound was fully characterized by FT-IR, 1H- and 13C-NMR, GC-MS, and elemental analysis. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the Molinspiration Cheminformatics software. The hybrid obtained could be an interesting model for antifungal bio-essays or a suitable precursor in the synthesis of more complex triazolyl-quinoline hybrids, potential pharmacological agents. View Full-Text
Keywords: 4-chloro-8-hydroxyquinoline; triazoles; conjugated triazolyl-quinoline hybrid; CuAAC; Lipinski’ descriptors 4-chloro-8-hydroxyquinoline; triazoles; conjugated triazolyl-quinoline hybrid; CuAAC; Lipinski’ descriptors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Luna Parada, L.K.; Kouznetsov, V.V. 5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline. Molbank 2019, 2019, M1038.

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