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Gold-Catalyzed Synthesis of 2-Sulfenylspiroindolenines via Spirocyclizations

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1 av. de la Terrasse, 91198 Gif-sur-Yvette cedex, France
Author to whom correspondence should be addressed.
Molbank 2018, 2018(1), M985;
Received: 7 February 2018 / Revised: 21 February 2018 / Accepted: 22 February 2018 / Published: 23 February 2018
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
2-Phenylsulfenyl-N-propargyl tryptamines have been prepared by electrophilic sulfuration of the corresponding tryptamines. These compounds undergo gold-catalyzed spirocyclizations to the corresponding 2-phenylthiospiroindolenines in good yields. The compounds were analyzed by NMR experiments, infrared, mass spectra and X-ray diffraction. This method provides a new efficient entry to the synthesis of 2-sulfenyl spiroindolic compounds. View Full-Text
Keywords: gold catalysis; indoles; alkynes; spiro compounds; sulfenyl group gold catalysis; indoles; alkynes; spiro compounds; sulfenyl group
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MDPI and ACS Style

Magné, V.; Retailleau, P.; Marinetti, A.; Voituriez, A.; Guinchard, X. Gold-Catalyzed Synthesis of 2-Sulfenylspiroindolenines via Spirocyclizations. Molbank 2018, 2018, M985.

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