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Molbank 2018, 2018(1), M985;

Gold-Catalyzed Synthesis of 2-Sulfenylspiroindolenines via Spirocyclizations

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1 av. de la Terrasse, 91198 Gif-sur-Yvette cedex, France
Author to whom correspondence should be addressed.
Received: 7 February 2018 / Revised: 21 February 2018 / Accepted: 22 February 2018 / Published: 23 February 2018
(This article belongs to the Special Issue Metal-Catalyzed Synthesis)
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2-Phenylsulfenyl-N-propargyl tryptamines have been prepared by electrophilic sulfuration of the corresponding tryptamines. These compounds undergo gold-catalyzed spirocyclizations to the corresponding 2-phenylthiospiroindolenines in good yields. The compounds were analyzed by NMR experiments, infrared, mass spectra and X-ray diffraction. This method provides a new efficient entry to the synthesis of 2-sulfenyl spiroindolic compounds. View Full-Text
Keywords: gold catalysis; indoles; alkynes; spiro compounds; sulfenyl group gold catalysis; indoles; alkynes; spiro compounds; sulfenyl group

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Magné, V.; Retailleau, P.; Marinetti, A.; Voituriez, A.; Guinchard, X. Gold-Catalyzed Synthesis of 2-Sulfenylspiroindolenines via Spirocyclizations. Molbank 2018, 2018, M985.

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