Special Issue "3D In Vitro Tissue and Organ Models"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Nur Mustafaoglu
E-Mail Website
Guest Editor
Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey
Interests: Organ-on-a-chip; Blood-Brain Barrier; Tissue Engineering; Mechanobiology; Biosensing; Disease Detection; Drug Delivery; Nanotherapeutics; Nanobiotechnology
Prof. Vasif Hasirci
E-Mail Website
Guest Editor
Medical Engineering, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey
Interests: Biomaterials; Tissue Engineering; 3D Printing; Additive Manufacturing; Nano-Micropatterned Surfaces; Tissue-Material Interactions; Drug Delivery; Hydrogels; Tissue models
Dr. Ken Takahashi
E-Mail Website
Guest Editor
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata Cho, Kita-Ward, Okayama 700-8558, Japan
Interests: cardiovascular regenerative medicine; ischemia-reperfusion injury; space medicine/biology
Special Issues and Collections in MDPI journals
Dr. Menekse Ermis
E-Mail Website
Guest Editor
Center of Excellence in Biomaterials and Tissue Engineering (BIOMATEN), Middle East Technical University, Ankara 06800, Turkey
Interests: biomaterials; cancer; microfluidics; 3D printing; soft tissues; cell-material interactions

Special Issue Information

Dear Colleagues,

We use animal models to test medications to improve human health (in vivo or preclinical applications), though animal organisms are not identical to human ones, whose responses can only be evaluated in clinical testing. Studies in academia and the pharmaceutical industry have consistently shown that preclinical animal models for drug research have failed. In fact, the failure rates of animal experiments are as high as 90%, as a result of both ineffectiveness and safety issues when testing the drugs in human clinical trials. Recapitulating physiologically significant human organ and tissue functions in vitro, therefore, becomes crucial for the development of new therapeutics and life-saving innovations. In vitro organ models can be used as substitutes for human organ transplants (ex vivo applications) and as alternatives to animal models for toxicology testing. Worldwide, the scientific community is focusing on advancing new technologies for tissue engineering, cell biology, 3D printing, and microfluidics to overcome the problems associated with existing in vitro models. Undeniably, creative design concepts and the inclusion of the developmental and cellular biology of the target tissues or organs are moving us closer to this ultimate goal. In addition, developments in material science for the manufacture of scaffolds or microfluidic systems using specific techniques are contributing significantly to the reconstitution of cellular microenvironments for whole organs or functional human tissue units. Many in vitro human models, however, require further improvement, refinement, and/or validation to be considered as functional substitutes of tissues for drug testing that will replace preclinical animal studies or of organs for transplantation.

This Special Issue welcomes your submission of research manuscripts and review articles that are related to advancements in the fields of tissue engineering, cell biology, material sciences and nanoscience and address the current challenges in the development of in vitro human tissue and organ models.

Dr. Nur Mustafaoglu
Prof. Vasif Hasirci
Dr. Ken Takahashi
Dr. Menekse Ermis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Tissue Engineering
  • Tissue Models
  • Organ Models
  • In vitro Models
  • Microphysiological Systems
  • Organ Chips (organ on a chip)
  • Microfluidics
  • Organoids
  • Spheroids
  • Stem Cell Technologies
  • Primary Cells
  • Transwell Models
  • Whole Organ Scaffolds
  • 3D Tissue/Organ Printing
  • Decellularization
  • Recellularization

Published Papers (1 paper)

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Fabrication of Stromal Cell-Derived Factor-1 Contained in Gelatin/Hyaluronate Copo006Cymer Mixed with Hydroxyapatite for Use in Traumatic Bone Defects
Micromachines 2021, 12(7), 822; https://doi.org/10.3390/mi12070822 - 14 Jul 2021
Viewed by 303
Bone defects of orthopedic trauma remain a challenge in clinical practice. Regarding bone void fillers, besides the well-known osteoconductivity of most bone substitutes, osteoinductivity has also been gaining attention in recent years. It is known that stromal cell-derived factor-1 (SDF-1) can recruit mesenchymal [...] Read more.
Bone defects of orthopedic trauma remain a challenge in clinical practice. Regarding bone void fillers, besides the well-known osteoconductivity of most bone substitutes, osteoinductivity has also been gaining attention in recent years. It is known that stromal cell-derived factor-1 (SDF-1) can recruit mesenchymal stem cells (MSCs) in certain circumstances, which may also play an important role in bone regeneration. In this study, we fabricated a gelatin/hyaluronate (Gel/HA) copolymer mixed with hydroxyapatite (HAP) and SDF-1 to try and enhance bone regeneration in a bone defect model. After material characterization, these Gel/HA–HAP and Gel/HA–HAP–SDF-1 composites were tested for their biocompatibility and ability to recruit MSCs in vitro. A femoral condyle bone defect model of rats was used for in vivo studies. For the assessment of bone healing, micro-CT analysis, second harmonic generation (SHG) imaging, and histology studies were performed. As a result, the Gel/HA–HAP composites showed no systemic toxicity to rats. Gel/HA–HAP composite groups both showed better bone generation compared with the control group in an animal study, and the composite with the SDF-1 group even showed a trend of faster bone growth compared with the composite without SDF-1 group. In conclusion, in the management of traumatic bone defects, Gel/HA–HAP–SDF-1 composites can be a feasible material for use as bone void fillers. Full article
(This article belongs to the Special Issue 3D In Vitro Tissue and Organ Models)
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