Special Issue "Cardiac Ischemia Reperfusion Injury"

A special issue of Hearts (ISSN 2673-3846).

Deadline for manuscript submissions: closed (1 July 2020).

Special Issue Editor

Dr. Ken Takahashi
E-Mail Website
Guest Editor
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata Cho, Kita-Ward, Okayama 700-8558, Japan
Interests: cardiovascular regenerative medicine; ischemia-reperfusion injury; space medicine/biology
Special Issues and Collections in MDPI journals

Special Issue Information

Cardiac ischemia-reperfusion (I/R) injury is a cause of ischemic heart disease (IHD). According to the World Health Organization, more than 9 million people died of IHD in 2016. I/R causes clinical manifestations such as arrhythmia, myocardial stunning, and no-reflow of vasculature, which may lead to the sudden death of patients. The vast pathophysiology of I/R injury consists of three major factors studied traditionally, namely, oxidative stress, complement activation, and inflammation. Recent interesting topics include the cardioprotective effects of remote ischemic conditioning, anesthetics, and long non-coding/micro RNAs. While a tremendous amount of research regarding cardiac I/R injury has been published, it is increasingly difficult to put individual findings together to develop effective clinical interventions. The purpose of this Special Issue is to digest recent research to better understand the mechanisms of I/R injury in a structured manner, and to ultimately link this research to clinical intervention at the bedside.

Dr. Ken Takahashi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Hearts is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • ischemic heart disease
  • oxidative stress
  • reactive oxygen species
  • complement activation
  • inflammation

Published Papers

There is no accepted submissions to this special issue at this moment.
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