Special Issue "Advanced FET Based Sensors for Life Science Applications"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B1: Biosensors".

Deadline for manuscript submissions: closed (1 July 2022) | Viewed by 2127

Special Issue Editor

Special Issue Information

Dear Colleagues,

Field-effect transistor (FET)-based biosensors have received great attention over the last two decades for life science applications. These sensors have been proven to be low cost, highly sensitive, label-free, and miniaturized with the perfect capability of integration with lab-on-a-chip (LOC) technologies. Biological FETs (BioFETs), or so-called FET biosensors, basically have the same structure as ion-sensitive FETs (ISFETs), but with the subtle difference that a new biorecognition element has already been covered at the gate. Based on their gate coverage, BioFETs can be Gen-FETs (DNA on the gate), Cell-FETs (biological cells on the gate), Enzyme-FETs (enzymatic reactions on the gate), etc. So far, various structures for BioFETs have been introduced. The vast majority of them are based on cleanroom microfabrication processes, which are not scalable due to the complexity of the fabrication process and the used materials. There are many novel FET sensors that are based on new materials such as carbon nanotubes, graphene, and many other 2D materials. While showing extraordinary sensitivity and improving other sensing features, these sensors are not scalable in mass fabrication. Nevertheless, there are many BioFET structures based on the well-established and almost flawless Complementary Metal Oxide Semiconductors (CMOS) technology such as extended gates, floating gates, floating-control gates, etc. Unmodified CMOS-based ISFETs (or BioFETs) are based on the mass-producible CMOS technology; however, there are disadvantages accompanying unmodified CMOS ISFET sensors. The long via pads used for connecting the gate to the channel are the source of parasitic capacitance errors that severely affect the sensor operation. Additionally, the necessity of using bulky Ag/AgCl electrodes in solution hampers further integration with lab-on-a-chip technologies for further personal health monitoring utilization. This Special Issue addresses the design, implementation, modelling, characterization, validation, and/or optimization of FET-based biosensors using standard microfabrication technologies including CMOS or Open-Gate Junction Field-Effect Transistors (OG-JFETs). Additionally, this Special Issue covers topics related to FET-based sensors using nanomaterials such as carbon nanotubes or graphene for bioengineering or biomedical engineering applications such as drug testing or other fundamental biological studies.

Dr. Ebrahim Ghafar-Zadeh
Guest Editor

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  • Field Effect Transistor (FET)
  • BioFET
  • nanomaterials
  • Ion-Selective Filed Effect Transistors (ISFET)
  • Complementary-Metal-Oxide-Semiconductor (CMOS) based FET sensors
  • pH sensors
  • DNA detection
  • Point-of-Care Disease Diagnostics (PoCDD)
  • life science applications

Published Papers (1 paper)

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A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications
Micromachines 2022, 13(3), 425; https://doi.org/10.3390/mi13030425 - 10 Mar 2022
Cited by 3 | Viewed by 1654
This paper presents a novel hybrid microfluidic electronic sensing platform, featuring an electronic sensor incorporated with a microfluidic structure for life science applications. This sensor with a large sensing area of 0.7 mm2 is implemented through a foundry process called Open-Gate Junction [...] Read more.
This paper presents a novel hybrid microfluidic electronic sensing platform, featuring an electronic sensor incorporated with a microfluidic structure for life science applications. This sensor with a large sensing area of 0.7 mm2 is implemented through a foundry process called Open-Gate Junction FET (OG-JFET). The proposed OG-JFET sensor with a back gate enables the charge by directly introducing the biological and chemical samples on the top of the device. This paper puts forward the design and implementation of a PDMS microfluidic structure integrated with an OG-JFET chip to direct the samples toward the sensing site. At the same time, the sensor’s gain is controlled with a back gate electrical voltage. Herein, we demonstrate and discuss the functionality and applicability of the proposed sensing platform using a chemical solution with different pH values. Additionally, we introduce a mathematical model to describe the charge sensitivity of the OG-JFET sensor. Based on the results, the maximum value of transconductance gain of the sensor is ~1 mA/V at Vgs = 0, which is decreased to ~0.42 mA/V at Vgs = 1, all in Vds = 5. Furthermore, the variation of the back-gate voltage from 1.0 V to 0.0 V increases the sensitivity from ~40 mV/pH to ~55 mV/pH. As per the experimental and simulation results and discussions in this paper, the proposed hybrid microfluidic OG-JFET sensor is a reliable and high-precision measurement platform for various life science and industrial applications. Full article
(This article belongs to the Special Issue Advanced FET Based Sensors for Life Science Applications)
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