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Dear Colleagues,

We are pleased to announce a new Special Issue entitled “Feature Papers of Micromachines in Biology and Biomedicine 2023”. In recent years, we have cooperated with some excellent scholars/scientific groups and published several very important high-level works, which have already been cited according to the data of Web of Science. We aim to introduce a new insight into science development or cutting-edge technology related to micromachines in the field of biology and biomedicine , which will make a great contribution to the community.

This Special Issue will be a collection of high-quality papers from excellent scholars around the world. Both original research articles and comprehensive review papers are welcome. The papers will be published, free of charge, with full open access after peer review to benefit both authors and readers.

You are welcome to send short proposals for submissions of feature papers to our Editorial Office ([email protected]) before submission. They will be evaluated by Editors first. Please note that selected full papers will still be subjected to a thorough and rigorous peer review.

We look forward to receiving your excellent work.

Prof. Dr. Nam-Trung Nguyen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Open AccessArticle

Innovative Fabrication of Hollow Microneedle Arrays Enabling Blood Sampling with a Self-Powered Microfluidic Patch

and

Micromachines 2023, 14(3), 615; https://doi.org/10.3390/mi14030615 - 07 Mar 2023

Viewed by 800

Abstract

Microneedles are gaining a lot of attention in the context of sampling cutaneous biofluids such as capillary blood. Their minimal invasiveness and user-friendliness make them a prominent substitute for venous puncture or finger-pricking. Although the latter is suitable for self-sampling, the impracticality of manual handling and the difficulty of obtaining enough qualitative sample is driving the search for better solutions. In this context, hollow microneedle arrays (HMNAs) are particularly interesting for completely integrating sample-to-answer solutions as they create a duct between the skin and the sampling device. However, the fabrication of sharp-tipped HMNAs with a high aspect ratio (AR) is challenging, especially since a length of ≥1500 μm is desired to reach the blood capillaries. In this paper, we first described a novel two-step fabrication protocol for HMNAs in stainless steel by percussion laser drilling and subsequent micro-milling. The HMNAs were then integrated into a self-powered microfluidic sampling patch, containing a capillary pump which was optimized to generate negative pressure differences up to 40.9 ± 1.8 kPa. The sampling patch was validated in vitro, showing the feasibility of sampling 40 μL of liquid. It is anticipated that our proof-of-concept is a starting point for more sophisticated all-in-one biofluid sampling and point-of-care testing systems. Full article

(This article belongs to the Special Issue Feature Papers of Micromachines in Biology and Biomedicine 2023)

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