Translational Microfluidics: From Lab Prototype to Scalable Manufacturing

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E:Engineering and Technology".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 683

Special Issue Editors


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Guest Editor
Department of Aerospace and Mechanical Engineering, South East Technological University, R93 V960 Carlow, Ireland
Interests: design and fabrication of microfluidics; intelligent manufacturing; vibration control
School of Mechanical and Materials Engineering, University College Dublin, D04 C1P1 Dublin, Ireland
Interests: micro/nano manufacturing; plastic microfluidic chip manufacturing; nanomedicine and diagnostics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
School of Mechanical and Materials Engineering, University College Dublin, D04 C1P1 Dublin, Ireland
Interests: lipid nanoparticles; microfluidic; Ti Implant

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Guest Editor Assistant
School of Mechanical and Materials Engineering, University College Dublin, D04 C1P1 Dublin, Ireland
Interests: micro fabrication; electrodeposition; nanocomposites

Special Issue Information

Dear Colleagues,

With the rapid evolution of microfluidic technologies toward real-world deployment, a major challenge lies in bridging the gap between innovative laboratory prototypes and scalable, reliable manufacturing processes. The Special Issue aims to highlight advances that integrate microfluidic design, simulation, prototyping, Systems integration and scalable manufacturing into a unified engineering pipeline. The main focus is on design, fabrication technologies, integration and scale-up production strategies accelerating the transition from laboratory concepts to deployable microfluidic technologies. Topics of interest include the following:

  1. Microfluidic design and simulation: CAD/CAE workflows, CFD modelling, optimization strategies, and design rules that support manufacturable microfluidic architectures.
  2. Prototyping and fabrication technologies: soft lithography (PDMS), laser micromachining, hot embossing, micro-CNC, and high-resolution 3D printing (e.g., DLP).
  3. Systems integration: embedding sensors, electrodes, microheaters, optical interfaces, and actuators for microfluidic systems.
  4. Scalable production and replication: electroforming, mould tooling, micro injection moulding, bonding, surface functionalization, and parallelized manufacturing processes.

Dr. Dongsheng Liu
Dr. Nan Zhang
Guest Editors

Dr. Mingzhi Yu
Dr. Tianyu Guan
Guest Editor Assistants

Manuscript Submission Information

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Keywords

  • microfluidic design
  • prototyping and fabrication technologies
  • systems integration
  • scalable manufacturing

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Published Papers (1 paper)

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Research

23 pages, 6751 KB  
Article
Generation Mechanism and Reynolds Number Regulation of Multi-Peak Oscillatory Concentration Gradients in Multi-Layer Vertical-Stepped Microchannels
by Zengliang Hu, Minghai Li, Guangda Liu, Xiaohui Jia and Zhenyu Fan
Micromachines 2026, 17(3), 294; https://doi.org/10.3390/mi17030294 - 27 Feb 2026
Viewed by 432
Abstract
This study systematically investigates the flow characteristics, mixing efficiency, and concentration gradient generation (CGG) capabilities of three types of vertical-stepped main-channel microfluidic concentration gradient generators—the upward vertical-step (UVS-GG), downward vertical-step (DVS-GG), and straight horizontal channel (SHC-GG)—under different Reynolds numbers (Re) through numerical simulation [...] Read more.
This study systematically investigates the flow characteristics, mixing efficiency, and concentration gradient generation (CGG) capabilities of three types of vertical-stepped main-channel microfluidic concentration gradient generators—the upward vertical-step (UVS-GG), downward vertical-step (DVS-GG), and straight horizontal channel (SHC-GG)—under different Reynolds numbers (Re) through numerical simulation and comparative analysis. Using numerical simulations, the research reveals the universal transition of flow regimes from diffusion-dominated to convection-dominated and reports the emergence of a “multi-peak oscillatory concentration gradient” phenomenon under stepped geometries and high Re (Re = 100, 200). The results indicate that the SHC-GG can generate monotonic gradients at low Re, making it an ideal baseline configuration. In contrast, UVS-GG and DVS-GG enhance mixing and enable the programming of complex concentration distributions through unique inertia–geometry coupling effects. The synergistic interaction between geometric configuration and Re is identified as the core mechanism for regulating concentration field morphology and device performance. This study provides key theoretical and design foundations for the rational design of microfluidic gradient generators targeting applications such as biological screening, chemical analysis, and material synthesis. Full article
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