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Special Issue "New Horizons for Amyloid Beta-Protein and Neurometabolism"
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 2881
Special Issue Editors
Interests: astrocyte; Alzheimer; calcium-binding proteins; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegeneration; neuroprotection; glutamate; purinergic signaling
Special Issue Information
Alzheimer’s disease (AD) is the main age-related neurodegenerative disease and is characterized by cognitive impairment and gradual damage in the function and structure of the hippocampus and cerebral cortex, two regions intimately related to memory and cognitive functioning. The neuropathologic hallmarks of AD include amyloid-beta (Aβ) formation and aggregation, and neurofibrillary tangles of hyperphosphorylated tau protein. Nevertheless, the early synaptic dysfunction in AD is associated with the oligomeric Aβ deposition and metabolic alterations, such as changes in glucose availability and metabolization pathways, endoplasmic reticulum and mitochondria dysfunction, oxidative stress and neuroinflammatory changes. It is essential that we know more about the metabolic changes that precede or accompany Aβ accumulation.
This Special Issue of Metabolites titled “New Horizons for Amyloid Beta-Protein and Neurometabolism” is dedicated to the evaluation of metabolic alterations associated with AD. Clinical, preclinical, imaging and bioinformatics studies concerning metabolomics analysis, cognitive assessment, bioenergetics, intermediate metabolites, endoplasmic reticulum stress, mitochondrial function/dysfunction, oxidative stress, biomarkers, neurotransmitters and signaling pathways are welcome. Additionally, manuscripts dealing with the identification of putative neuroprotective strategies and their effects on neurometabolism are also highly desired.
Prof. Dr. Carlos Alberto Gonçalves
Prof. Dr. Carla Inês Tasca
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Alzheimer´s disease
- amyloid-beta production
- amyloid-beta clearance
- ER stress
- oxidative stress
- mitochondrial dysfunction