Skeletal Muscle Fiber Phenotype as Determinant of Metabolism and Function in Health and Disease

Dear Colleagues,

In addition to maintaining body posture and mobility, skeletal muscle affects the efficacy of daily physical activities, athletic performance, and overall health. Thus, skeletal muscle fiber types play a crucial role in both health and disease in determining muscle function and metabolism. Understanding the molecular, cellular, and physiological characteristics of skeletal muscle fibers and their distribution in muscle is crucial for advancing our understanding of muscle-related disorders and devising targeted therapeutics. This Special Issue aims to compile the most recent research and developments that investigate various aspects of skeletal muscle fibers, their regulation, and their implications for health and disease states, and to provide a forum for researchers and academics to share their insights and discoveries. We invite original research articles, reviews, meta-analyses, and case studies that explore various aspects of fibers in skeletal muscle, including, but not limited to, the following topics:

• Molecular and cellular mechanisms underlying muscle fiber type determination.
• Approaches to classify muscle fiber types in muscle.
• Influence of exercise and physical activity (or physical inactivity) on muscle fiber type composition and performance.
• Role of nutrition and metabolic factors in shaping muscle fiber type characteristics.
• Muscle fiber type adaptations to different training modalities (e.g., resistance training, endurance training).
• Muscle fiber type plasticity and its role in muscle regeneration and repair.
• Muscle fiber type in aging and age-related muscle disorders.
• Role of muscle fiber type in metabolic disorders (e.g., diabetes, obesity).
• Muscle fiber characteristics in neuromuscular diseases (e.g., muscular dystrophy, myopathies).
• Therapeutic interventions targeting muscle fiber types for disease management.
• Emerging methodologies and tools for investigating muscle fiber types.

Dr. Christos Katsanos
Prof. Dr. Walter Wahli
Guest Editors

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