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Metabolites
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Skeletal Muscle Fiber Phenotype as Determinant of Metabolism and Function...
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Skeletal Muscle Fiber Phenotype as Determinant of Metabolism and Function in Health and Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 4267

Special Issue Editors

Dr. Christos Katsanos

E-Mail Website
Guest Editor
School of Life Sciences, Arizona State University, Tempe, AZ 85297, USA
Interests: skeletal muscle; muscle fibers; muscle metabolism; muscle mitochondria; muscle protein turnover; muscle proteomics; nutrition; exercise; aging; obesity
Prof. Dr. Walter Wahli

E-Mail Website
Guest Editor
1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore
2. Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland
Interests: nuclear receptor superfamily; gene regulation and gene expression profiling; metabolic regulations; development; skin and wound healing; cancer; liver physiology; non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH); adipose tissue; muscle and exercise; gut; microbiota; inter-organ cross-talk; nutrition; nutrigenetics and nutrigenomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In addition to maintaining body posture and mobility, skeletal muscle affects the efficacy of daily physical activities, athletic performance, and overall health. Thus, skeletal muscle fiber types play a crucial role in both health and disease in determining muscle function and metabolism. Understanding the molecular, cellular, and physiological characteristics of skeletal muscle fibers and their distribution in muscle is crucial for advancing our understanding of muscle-related disorders and devising targeted therapeutics. This Special Issue aims to compile the most recent research and developments that investigate various aspects of skeletal muscle fibers, their regulation, and their implications for health and disease states, and to provide a forum for researchers and academics to share their insights and discoveries. We invite original research articles, reviews, meta-analyses, and case studies that explore various aspects of fibers in skeletal muscle, including, but not limited to, the following topics:

  • Molecular and cellular mechanisms underlying muscle fiber type determination.
  • Approaches to classify muscle fiber types in muscle.
  • Influence of exercise and physical activity (or physical inactivity) on muscle fiber type composition and performance.
  • Role of nutrition and metabolic factors in shaping muscle fiber type characteristics.
  • Muscle fiber type adaptations to different training modalities (e.g., resistance training, endurance training).
  • Muscle fiber type plasticity and its role in muscle regeneration and repair.
  • Muscle fiber type in aging and age-related muscle disorders.
  • Role of muscle fiber type in metabolic disorders (e.g., diabetes, obesity).
  • Muscle fiber characteristics in neuromuscular diseases (e.g., muscular dystrophy, myopathies).
  • Therapeutic interventions targeting muscle fiber types for disease management.
  • Emerging methodologies and tools for investigating muscle fiber types.

Dr. Christos Katsanos
Prof. Dr. Walter Wahli
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • muscle fiber types
  • muscle fiber characteristics
  • myosin heavy chain
  • slow and fast muscle fibers
  • muscle composition
  • muscle function
  • muscle disorders
  • muscle-related diseases
  • muscle fiber plasticity

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Published Papers (2 papers)

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Research

13 pages, 1416 KiB  
Article
The ARK2N (C18ORF25) Genetic Variant Is Associated with Muscle Fiber Size and Strength Athlete Status
by Rukiye Çığırtaş, Celal Bulgay, Hasan Hüseyin Kazan, Onur Akman, Goran Sporiš, George John, Rinat A. Yusupov, Rinat I. Sultanov, Andrey V. Zhelankin, Ekaterina A. Semenova, Andrey K. Larin, Nikolay A. Kulemin, Edward V. Generozov, Damir Jurko and Ildus I. Ahmetov
Metabolites 2024, 14(12), 684; https://doi.org/10.3390/metabo14120684 - 5 Dec 2024
Viewed by 1511
Abstract
Background: Data on the genetic factors contributing to inter-individual variability in muscle fiber size are limited. Recent research has demonstrated that mice lacking the Arkadia (RNF111) N-terminal-like PKA signaling regulator 2N (Ark2n; also known as C18orf25) gene exhibit reduced muscle [...] Read more.
Background: Data on the genetic factors contributing to inter-individual variability in muscle fiber size are limited. Recent research has demonstrated that mice lacking the Arkadia (RNF111) N-terminal-like PKA signaling regulator 2N (Ark2n; also known as C18orf25) gene exhibit reduced muscle fiber size, contraction force, and exercise capacity, along with defects in calcium handling within fast-twitch muscle fibers. However, the role of the ARK2N gene in human muscle physiology, and particularly in athletic populations, remains poorly understood. The aim of this study was threefold: (a) to compare ARK2N gene expression between power and endurance athletes; (b) to analyze the relationship between ARK2N gene expression and muscle fiber composition; and (c) to investigate the association between the functional variant of the ARK2N gene, muscle fiber size, and sport-related phenotypes. Results: We found that ARK2N gene expression was significantly higher in power athletes compared to endurance athletes (p = 0.042) and was positively associated with the proportion of oxidative fast-twitch (type IIA) muscle fibers in untrained subjects (p = 0.017, adjusted for age and sex). Additionally, we observed that the ARK2N rs6507691 T allele, which predicts high ARK2N gene expression (p = 3.8 × 10−12), was associated with a greater cross-sectional area of fast-twitch muscle fibers in strength athletes (p = 0.015) and was over-represented in world-class strength athletes (38.6%; OR = 2.2, p = 0.023) and wrestlers (33.8%; OR = 1.8, p = 0.044) compared to controls (22.0%). Conclusions: In conclusion, ARK2N appears to be a gene specific to oxidative fast-twitch myofibers, with its functional variant being associated with muscle fiber size and strength-athlete status. Full article
(This article belongs to the Special Issue Skeletal Muscle Fiber Phenotype as Determinant of Metabolism and Function in Health and Disease)
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14 pages, 3618 KiB  
Article
Poly(ADP-Ribose) Polymerases-Inhibitor Talazoparib Inhibits Muscle Atrophy and Fatty Infiltration in a Tendon Release Infraspinatus Sheep Model: A Pilot Study
by Maurits G. L. Olthof, Anita Hasler, Paola Valdivieso, Martin Flück, Christian Gerber, Rieke Gehrke, Karina Klein, Brigitte von Rechenberg, Jess G. Snedeker and Karl Wieser
Metabolites 2024, 14(4), 187; https://doi.org/10.3390/metabo14040187 - 26 Mar 2024
Cited by 1 | Viewed by 1786
Abstract
Structural muscle changes, including muscle atrophy and fatty infiltration, follow rotator cuff tendon tear and are associated with a high repair failure rate. Despite extensive research efforts, no pharmacological therapy is available to successfully prevent both muscle atrophy and fatty infiltration after tenotomy [...] Read more.
Structural muscle changes, including muscle atrophy and fatty infiltration, follow rotator cuff tendon tear and are associated with a high repair failure rate. Despite extensive research efforts, no pharmacological therapy is available to successfully prevent both muscle atrophy and fatty infiltration after tenotomy of tendomuscular unit without surgical repair. Poly(ADP-ribose) polymerases (PARPs) are identified as a key transcription factors involved in the maintenance of cellular homeostasis. PARP inhibitors have been shown to influence muscle degeneration, including mitochondrial hemostasis, oxidative stress, inflammation and metabolic activity, and reduced degenerative changes in a knockout mouse model. Tenotomized infraspinatus were assessed for muscle degeneration for 16 weeks using a Swiss Alpine sheep model (n = 6). All sheep received daily oral administration of 0.5 mg Talazoparib. Due to animal ethics, the treatment group was compared with three different controls from prior studies of our institution. To mitigate potential batch heterogeneity, PARP-I was evaluated in comparison with three distinct control groups (n = 6 per control group) using the same protocol without treatment. The control sheep were treated with an identical study protocol without Talazoparib treatment. Muscle atrophy and fatty infiltration were evaluated at 0, 6 and 16 weeks post-tenotomy using DIXON-MRI. The controls and PARP-I showed a significant (control p < 0.001, PARP-I p = 0.01) decrease in muscle volume after 6 weeks. However, significantly less (p = 0.01) atrophy was observed in PARP-I after 6 weeks (control 1: 76.6 ± 8.7%; control 2: 80.3 ± 9.3%, control 3: 73.8 ± 6.7% vs. PARP-I: 90.8 ± 5.1% of the original volume) and 16 weeks (control 1: 75.7 ± 9.9; control 2: 74.2 ± 5.6%; control 3: 75.3 ± 7.4% vs. PARP-I 93.3 ± 10.6% of the original volume). All experimental groups exhibited a statistically significant (p < 0.001) augmentation in fatty infiltration following a 16-week period when compared to the initial timepoint. However, the PARP-I showed significantly less fatty infiltration (p < 0.003) compared to all controls (control 1: 55.6 ± 6.7%, control 2: 53.4 ± 9.4%, control 3: 52.0 ± 12.8% vs. PARP-I: 33.5 ± 8.4%). Finally, a significantly (p < 0.04) higher proportion and size of fast myosin heavy chain-II fiber type was observed in the treatment group. This study shows that PARP-inhibition with Talazoparib inhibits the progression of both muscle atrophy and fatty infiltration over 16 weeks in retracted sheep musculotendinous units. Full article
(This article belongs to the Special Issue Skeletal Muscle Fiber Phenotype as Determinant of Metabolism and Function in Health and Disease)
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