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Advances in Skin Wound Healing
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Advances in Skin Wound Healing

A topical collection in Medical Sciences (ISSN 2076-3271). This collection belongs to the section "Translational Medicine".

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Editors

Dr. Heiko Sorg

E-Mail Website
Collection Editor
Department of Plastic and Reconstructive Surgery, Marien Hospital Witten, 58452 Witten, Germany
Interests: wound healing; wounds; plastic surgery; burns; plastic and reconstructive surgery; wound phases, angiogenesis, career in medicine
Dr. Daniel J. Tilkorn

E-Mail Website
Collection Editor
Department of Plastic, Reconstructive and Aesthetic Surgery, Hand surgery, Alfried Krupp Krankenhaus, 45273 Essen, Germany
Interests: skin wound healing

Topical Collection Information

Dear Colleagues,

The ability to heal wounds has always given a decisive evolutionary advantage to species, and especially to human beings. Therefore, it represents one of the most important biological processes in the human organism. Although the experimental research, especially in the last few decades, has presented the general steps in the wound-healing process and some significant progress in the treatment of wounds has been achieved, many questions remain unanswered. In addition, chronic or non-healing wounds represent a growing health problem worldwide. The underlying pathogenesis of chronic wounds is further complicated by factors such as advanced age, poor nutrition, metabolic disorders, and immunosuppression, which trigger additional cellular and systemic stress and thus delay the wound-healing process.

This Topical Collection will provide up-to-date information regarding the general steps in the wound-healing process with its participant cells, the extracellular matrix, cytokines, chemokines, and growth factors, as well as their interactions with the microenvironment during various phases. Furthermore, differences in wound-healing processes in different skin tissues such as mucosa, scar, genital skin, and in pathologic skin wound-healing processes are discussed. A further focus will be on current conservative and surgical measures that can be taken to improve wound healing and modern wound management.

Therefore, we look forward to receiving a comprehensive overview of this topic which highlights the current knowledge and therapies in skin wound healing and provides future outlooks regarding interesting and promising approaches to address the current problems in wound-healing disorders.

Dr. Heiko Sorg
Dr. Daniel J. Tilkorn
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medical Sciences is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • wound-healing disorders
  • mucosa
  • scar
  • wound phases
  • angiogenesis

Published Papers (4 papers)

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2024

Jump to: 2023

14 pages, 22788 KiB  
Article
Could Fibrin Sealants (TISSEELTM) Be Effective in the Management of Burn Injuries? A Histopathological Study in Rats
by Christina Nikolaou, Maximos Frountzas, Dimitrios Schizas, Vasilios Pergialiotis, Emmanouil I. Kapetanakis, Konstantinos Kontzoglou, Despina N. Perrea, Efthymios Koniaris, Stylianos Kykalos and Dimitrios Iliopoulos
Med. Sci. 2024, 12(4), 75; https://doi.org/10.3390/medsci12040075 - 19 Dec 2024
Viewed by 858
Abstract
Background: Burn injuries remain a major clinical problem worldwide, which require special management by experienced plastic surgeons. However, they cannot be available in every healthcare unit; consequently, there is a need for effective treatment options that could be utilized by a wide range [...] Read more.
Background: Burn injuries remain a major clinical problem worldwide, which require special management by experienced plastic surgeons. However, they cannot be available in every healthcare unit; consequently, there is a need for effective treatment options that could be utilized by a wide range of non-expert healthcare professionals. The aim of the present experimental study was to investigate the safety and efficacy of using a fibrin sealant (TISSEELTM) compared to the conventional treatment with sulfadiazine on partial-thickness burn in a rat animal model. Methods: A cohort of Sprague Dawley rats underwent partial-thickness contact thermal burn wounds and were divided into three study groups: control group (no treatment), silver sulfadiazine cream group and TISSEELTM group. Following animal sacrifice, a blinded histopathologic analysis was conducted regarding inflammatory response, healing and tissue regeneration. Results: In total, 30 animals were included with a median weight of 236 ± 10 g. Two animals from the control group died on the first postoperative day. Animals in the TISSEELTM group presented dominant collagen expression compared to animals in the control and silver sulfadiazine cream group (p = 0.000). Histopathologic analysis also demonstrated marked leukocyte infiltration (p = 0.009), increased neovascularization (p = 0.000) and higher fibroblast expression (p = 0.002) in the TISSEELTM group compared to the other two groups. Conclusions: TISSEELTM seems to be a safe alternative (or even principal) option for the initial therapeutic approach of partial-thickness burn injuries. Moreover, it seems to be superior to silver sulfadiazine in terms of tissue healing and regeneration. However, additional experimental as well as clinical research is necessary prior to implementation in clinical practice. Full article
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2023

Jump to: 2024

9 pages, 1280 KiB  
Technical Note
The LipoDerm Method for Regeneration and Reconstruction in Plastic Surgery: A Technical Experimental Ex Vivo Note
by Ziyad Alharbi, Sarah Qari, Maryam Bader, Sherif Khamis, Faris Almarzouqi, Michael Vogt and Christian Opländer
Med. Sci. 2023, 11(1), 16; https://doi.org/10.3390/medsci11010016 - 3 Feb 2023
Cited by 2 | Viewed by 2906
Abstract
The combination of adipose-derived stem cells (ASCs) and dermal scaffolds has been shown to be an approach with high potential in soft tissue reconstruction. The addition of dermal templates to skin grafts can increase graft survival through angiogenesis, improve regeneration and healing time, [...] Read more.
The combination of adipose-derived stem cells (ASCs) and dermal scaffolds has been shown to be an approach with high potential in soft tissue reconstruction. The addition of dermal templates to skin grafts can increase graft survival through angiogenesis, improve regeneration and healing time, and enhance the overall appearance. However, it remains unknown whether the addition of nanofat-containing ASCs to this construct could effectively facilitate the creation of a multi-layer biological regenerative graft, which could possibly be used for soft tissue reconstruction in the future in a single operation. Initially, microfat was harvested using Coleman’s technique, then isolated through the strict protocol using Tonnard’s technique. Finally, centrifugation, emulsification, and filtration were conducted to seed the filtered nanofat-containing ASCs onto Matriderm for sterile ex vivo cellular enrichment. After seeding, a resazurin-based reagent was added, and the construct was visualized using two-photon microscopy. Within 1 h of incubation, viable ASCs were detected and attached to the top layer of the scaffold. This experimental ex vivo note opens more dimensions and horizons towards the combination of ASCs and collagen–elastin matrices (i.e., dermal scaffolds) as an effective approach in soft tissue regeneration. The proposed multi-layered structure containing nanofat and dermal template (Lipoderm) may be used, in the future, as a biological regenerative graft for wound defect reconstruction and regeneration in a single operation and can also be combined with skin grafts. Such protocols may optimize the skin graft results by creating a multi-layer soft tissue reconstruction template, leading to more optimal regeneration and aesthetic outcomes. Full article
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9 pages, 237 KiB  
Article
Free Flaps for Skin and Soft Tissue Reconstruction in the Elderly Patient: Indication or Contraindication
by Heiko Sorg, Christian G. G. Sorg, Daniel J. Tilkorn, Simon Thönnes, Rees Karimo and Jörg Hauser
Med. Sci. 2023, 11(1), 12; https://doi.org/10.3390/medsci11010012 - 21 Jan 2023
Cited by 4 | Viewed by 2356
Abstract
Background: Increased lifespan and the improvement of medical treatment have given rise to research in reconstructive procedures in elderly patients. Higher postoperative complication rates, longer rehabilitation, and surgical difficulties remain a problem in the elderly. We asked whether a free flap in elderly [...] Read more.
Background: Increased lifespan and the improvement of medical treatment have given rise to research in reconstructive procedures in elderly patients. Higher postoperative complication rates, longer rehabilitation, and surgical difficulties remain a problem in the elderly. We asked whether a free flap in elderly patients is an indication or a contraindication and performed a retrospective, monocentric study. Methods: Patients were divided into two groups (YOUNG 0–59 years; OLD > 60 years). The endpoint was the survival of flaps and their dependence on patient- and surgery-specific parameters using multivariate analysis. Results: A total of 110 patients (OLD n = 59) underwent 129 flaps. The chance of flap loss increased as soon as two flaps were performed in one surgery. Anterior lateral thigh flaps had the highest chance for flap survival. Compared with the lower extremity, the head/neck/trunk group had a significantly increased chance of flap loss. There was a significant increase in the odds of flap loss in linear relation to the administration of erythrocyte concentrates. Conclusion: The results confirm that free flap surgery can be indicated as a safe method for the elderly. Perioperative parameters such as two flaps in one surgery and transfusion regimens must be considered as risk factors for flap loss. Full article
13 pages, 2383 KiB  
Perspective
Effects of Electrical Stimulation of the Cell: Wound Healing, Cell Proliferation, Apoptosis, and Signal Transduction
by Kazuo Katoh
Med. Sci. 2023, 11(1), 11; https://doi.org/10.3390/medsci11010011 - 17 Jan 2023
Cited by 33 | Viewed by 6569
Abstract
Electrical stimulation of the cell can have a number of different effects depending on the type of cell being stimulated. In general, electrical stimulation can cause the cell to become more active, increase its metabolism, and change its gene expression. For example, if [...] Read more.
Electrical stimulation of the cell can have a number of different effects depending on the type of cell being stimulated. In general, electrical stimulation can cause the cell to become more active, increase its metabolism, and change its gene expression. For example, if the electrical stimulation is of low intensity and short duration, it may simply cause the cell to depolarize. However, if the electrical stimulation is of high intensity or long duration, it may cause the cell to become hyperpolarized. The electrical stimulation of cells is a process by which an electrical current is applied to cells in order to change their function or behavior. This process can be used to treat various medical conditions and has been shown to be effective in a number of studies. In this perspective, the effects of electrical stimulation on the cell are summarized. Full article
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