Special Issue "Minimally Invasive and Fertility-Sparing Treatment of Gynecological Cancers"

A special issue of Medicina (ISSN 1010-660X). This special issue belongs to the section "Obstetrics and Gynecology".

Deadline for manuscript submissions: 1 April 2021.

Special Issue Editors

Prof. Dr. Simone Ferrero
Guest Editor
IRCCS, Ospedale Policlinico San Martino, University of Genova, Genova, Italy
Interests: Angiogenesis; gynecological surgery; intrauterine growth restriction; preterm delivery
Special Issues and Collections in MDPI journals
Dr. Fabio Barra
Guest Editor
IRCCS, Ospedale Policlinico San Martino, University of Genova, Genova, Italy
Interests: endometriosis; inflammation; minimally invasive surgery

Special Issue Information

Dear Colleagues,

The need to provide curative but less-morbid therapeutic options for women affected by gynecological cancers has been appreciated in recent years, with a relevant increase in the number of studies focused on the potential benefits and risks of minimally invasive fertility-sparing surgical procedures.

The objective of fertility-sparing treatment in patients affected by gynecological cancers is to guarantee adequate reproductive function while maintaining a low risk of long-term disease recurrence. The management of patients wishing to maintain fertility is complex and requires adequate counselling from a multidisciplinary team; working closely and engaging in discussion with fertility specialists is a prerequisite if women are to be given the best chance of obtaining a successful future pregnancy.

Currently, there are several key factors influencing the recommendation for fertility-sparing surgery, and the preoperative planning of these surgical procedures should be based on the optimal selection of patients with an accurate preoperative examination. Oncologic and obstetric outcomes related to the specific type of surgical approach and the necessity of adjuvant medical options should be assessed.

There are several approaches for fertility preservation in cervical cancer, such as cervical conization or radical trachelectomy. Uterine-sparing options such as hormonal therapy (in primis progestins) may be considered for women with early-stage, low-grade endometrial cancer. Ovarian borderline tumors tend to be diagnosed more commonly in younger women, and for this reason can often be treated with conservative surgery. Fertility-sparing surgery in combination with comprehensive surgical staging may be performed in selected young patients with invasive ovarian cancer and apparent disease confined to one ovary.

This Special Issue shall welcome contributions of original articles as well as narrative and systematic reviews, with or without meta-analysis. Overall, this Issue aims to provide summaries of the current evidence, in addition to new developing discoveries and future directions in the field of the minimally invasive and fertility-sparing treatment of gynecological cancers.

Prof. Dr. Simone Ferrero
Dr. Fabio Barra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Fertility-sparing surgery
  • Endometrial cancer
  • Cervical cancer
  • Ovarian cancer
  • Conization
  • Trachelectomy
  • Sentinel lymph node
  • Progestins
  • Oophorectomy

Published Papers

This special issue is now open for submission.
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