Clinical Treatment of Neuroendocrine Neoplasm
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 190
Special Issue Editors
Interests: nuclear medicine; peptide receptor radionuclide therapy; endocrinology; oncology; computed tomography
Special Issues, Collections and Topics in MDPI journals
Interests: nuclear medicine; peptide receptor radionuclide therapy; endocrinology; computed tomography; emergency radiology; chest imaging; gastrointestinal imaging; urinary imaging; trauma imaging; bowel imaging; interventional radiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroendocrine neoplasms (NENs) constitute a heterogeneous group of malignancies arising from the diffuse neuroendocrine cell system.
Gastro-entero-pancreatic (GEP) NENs account for more than 70% of NENs, followed by the lung. These tumors share the ability to overexpress somatostatin receptors (SSTRs). About 90% of cases are well differentiated forms of neuroendocrine tumors (NETs), with slow proliferation and prolonged surviva rates.
Histological diagnosis is mandatory in all NENs patients, and the neuroendocrine phenotype is proven by the immunohistochemical analysis of the neuroendocrine markers, such as synaptophysin and/or chromogranin A. According to Ki-67 index and mitotic count, the disease stage and tumor grade are two fundamental independent prognostic factors, in-fact the low-grade tumors are classified as grade 1 (G1), intermediate-grades as grade 2 (G2) and high-grades as grade 3 (G3).
Computed tomography (CT) constitutes the primary radiological imaging for NENs to detect the primary and secondary lesions.
In loco-regional disease, surgery is the treatment of choice, while the goal of systemic therapy with somatostatin analogue therapy (SSAs) is to control the clinical symptoms and the tumour growth.
Further systemic therapies are recommended for their antiproliferative effect on NENs patients, such as IFN-a, Everolimus, Chemiotherapy and Sunitinib.
In recent years, nuclear medicine has also played an important role in the management and diagnosis of NENs. In this context positron emission tomography/computed tomography (PET/CT) and peptide receptor radionuclide therapy (PRRT) have been approved by the European Medicines Agency and Food and Drug Administration in the pathway of these patients.
Dr. Michele Klain
Guest Editor
Dr. Leandra Piscopo
Guest Editor Assistant
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Keywords
- neuroendocrine neoplasms
- neuroendocrine cell system
- gastro-entero-pancreatic NENs
- immunohistochemical analysis
- Ki-67 index
- mitotic count
- somatostatin analogue therapy
- antiproliferative effect
- positron emission tomography/computed tomography (PET/CT)
- peptide receptor radionuclide therapy (PRRT)
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