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Medicina
Special Issues
Current View of Foot and Ankle
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Current View of Foot and Ankle

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 7000

Special Issue Editor

Dr. Euidong Yeo

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, Veterans Health Service Medical Center, Seoul 05368, Korea
Interests: orthopaedics; foot and ankle; sports medicine; diabetic foot; infection

Special Issue Information

Dear Colleagues,

In orthopedic surgery, the department of the foot and ankle is a special field and has been rapidly changing and developing in recent years. This Special Issue intends to share the latest knowledge on arthroscopy, sports injury, arthroplasty, deformity, minimally invasive treatment, non-surgical treatment and treatment of various diseases, which are showing particular interest and change in the department of the foot and ankle.

Dr. Euidong Yeo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arthroscopy
  • sports injury
  • arthroplasty
  • deformity
  • minimally invasive treatment
  • non-surgical treatment

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Published Papers (2 papers)

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Research

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16 pages, 6694 KiB  
Article
Eichhornia crassipes Ameliorated Rheumatoid Arthritis by Modulating Inflammatory Cytokines and Metalloproteinase Enzymes in a Rat Model
by Sara Sattar, Arham Shabbir, Muhammad Shahzad, Tasleem Akhtar, Arfan Ahmad, Sulaiman Mohammed Alnasser, Bushra Riaz, Shaik Karimullah and Ashfaq Ahmad
Medicina 2023, 59(9), 1594; https://doi.org/10.3390/medicina59091594 - 4 Sep 2023
Cited by 2 | Viewed by 3321
Abstract
Background and Objectives: This study was planned to investigate the anti-arthritic property of flowers of E. crassipes in a Sprague–Dawley rat model by administering Freund’s Complete Adjuvant (FCA). Materials and Methods: Arthritis was induced at day 0 in all rats except [...] Read more.
Background and Objectives: This study was planned to investigate the anti-arthritic property of flowers of E. crassipes in a Sprague–Dawley rat model by administering Freund’s Complete Adjuvant (FCA). Materials and Methods: Arthritis was induced at day 0 in all rats except negative controls, while arthritic progress and paw edema were analyzed on specific days (8th, 13th, 18th, and 23rd) via the macroscopic arthritic scale and a digital Vernier caliper, respectively. Histopathological parameters were examined using a Hematoxylin and Eosin (H&E) staining method. Blood samples were withdrawn from rats to investigate the effects of the E. crassipes flower on the mRNA expression values of inflammatory markers, via a reverse transcription PCR technique. Serum samples were used to determine prostaglandin E2 (PGE2) levels using enzyme-linked immunosorbent assay (ELISA). Values of alanine transaminase (ALT), aspartate aminotransferase (AST), creatinine, and urea, besides hematological parameters, i.e., the hemoglobin (Hb) content and complete blood count (CBC), were investigated. Results: The data showed that E. crassipes inhibited the arthritic progress and ameliorated the paw edema. The amelioration of parameters assessed via the histopathological analysis of ankle joints, as well as via hematological analysis, confirmed the diminution of rheumatoid arthritis (RA) in the plant-treated groups. Treatment with E. crassipes inhibited the expression levels of tumor necrosis factor-α (TNF-α), interleukins (IL-1β and IL-6), nuclear factor KappaB (NF-κB), matrix metalloproteinase (MMP-2 and MMP-3), and vascular endothelial growth factor (VEGF). Serum PGE2 levels were also found to be reduced in treatment groups. A biochemical investigation revealed the improvements in hepatic markers in plant-treated groups. The data indicated that the plant has no hepatotoxic or nephrotoxic effects at the studied dose. GC-MS (Gas Chromatography-Mass Spectrometry) analysis displayed the presence of phytochemicals having known anti-inflammatory and antioxidant properties. Conclusions: Therefore, it may be concluded that E. crassipes possesses anti-arthritic characteristics that could be attributed to the modulation of pro-inflammatory cytokines, MMPs, and PGE2 levels. Full article
(This article belongs to the Special Issue Current View of Foot and Ankle)
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Review

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11 pages, 2447 KiB  
Review
Influence of Patient-Reported Outcome Measures by Surgical Versus Conservative Management in Adult Ankle Fractures: A Systematic Review and Meta-Analysis
by Hui Peng, Xiao-Bo Guo and Jin-Min Zhao
Medicina 2023, 59(6), 1152; https://doi.org/10.3390/medicina59061152 - 15 Jun 2023
Cited by 3 | Viewed by 3013
Abstract
Background and Objective: This meta-analysis was performed to compare the effectiveness of surgical treatment and conservative treatment in adult ankle fractures. Methods: Pubmed, Embase, and Cochrane-Library databases were searched to retrieve prospective randomized-controlled studies that compared the efficacy of surgical treatment [...] Read more.
Background and Objective: This meta-analysis was performed to compare the effectiveness of surgical treatment and conservative treatment in adult ankle fractures. Methods: Pubmed, Embase, and Cochrane-Library databases were searched to retrieve prospective randomized-controlled studies that compared the efficacy of surgical treatment and conservative treatment in adult ankle fractures. The meta package in R language was used to organize and analyze the obtained data. Results: A total of eight studies involving 2081 patients was considered eligible, including 1029 patients receiving surgical treatment and 1052 receiving conservative treatment. This systematic review and meta-analysis was prospectively registered on PROSPERO, and the registration number is CRD42018520164. Olerud and Molander ankle-fracture scores (OMAS) and the health survey 12-item Short-Form (SF-12) were used as main outcome indicators, and the follow-up outcomes were grouped according to the follow-up time. Meta-analysis results showed significantly higher OMAS scores in patients receiving surgical treatment than those with conservative treatment at six months (MD = 1.50, 95% CI: 1.07; 1.93) and over 24 months (MD = 3.10, 95% CI: 2.46; 3.74), while this statistical significance was absent at 12–24 months (MD = 0.08, 95% CI: −5.80; 5.96). At six months and 12 months after treatment, patients receiving surgical treatment exhibited significantly higher SF12-physical results than those receiving conservative treatment (MD = 2.40, 95% CI: 1.89; 2.91). The MD of SF12-mental data at six months after meta-analysis was −0.81 (95% CI: −1.22; 0.39), and the MD of SF12-mental data at 12+ months was −0.81 (95% CI: −1.22; 0.39). There was no significant difference in SF12-mental results between the two treatment methods after six months, but after 12 months, the SF12-mental results of patients receiving surgical treatment were significantly lower than those of conservative treatment. Conclusions: In the treatment of adult ankle fractures, surgical treatment is more efficacious than conservative treatment in improving early and long-term joint function and physical health of patients, but it is associated with long-term adverse mental health. Full article
(This article belongs to the Special Issue Current View of Foot and Ankle)
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