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Medicina
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Advancements in Dental Medicine, Oral Anesthesiology and Surgery
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Advancements in Dental Medicine, Oral Anesthesiology and Surgery

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 4701

Special Issue Editors

Prof. Dr. Cosmin Sinescu

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Guest Editor
Department of Prostheses Technology and Dental Materials, Research Center in Dental Medicine Using Conventional and Alternative Technologies, “Victor Babes” University of Medicine and Pharmacy, 300070 Timisoara, Romania
Interests: dental medicine; biomaterials; prosthodontics; dental treatments; biomedical imaging; optical coherence tomography (OCT)
Special Issues, Collections and Topics in MDPI journals
Dr. Ciprian Roi

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Guest Editor Assistant
Department of Anesthesiology and Oral Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania
Interests: dental anesthesiology; oral surgery; maxillofacial infections; oral pathology; trauma
Prof. Dr. Mircea Riviș

E-Mail Website
Guest Editor Assistant
Department of Anesthesiology and Oral Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania
Interests: oral surgery; maxillofacial surgery; dental trauma; oral infections

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue entitled “Advancements in Dental Medicine, Oral Anesthesiology and Surgery” which will be published in the MDPI journal Medicina (Q1). This Special Issue addresses the continuous development and research in the dentistry field, aiming to provide a significant perspective upon the new existent diagnosis and treatment approaches in different oral pathologies. Topics include the diagnosis and novelty in the treatment options of oral diseases, oral tissue regeneration, periodontology and implantology, materials and oral medical devices, and surgical and oral anesthesia advancements in the oral cavity.

This Special Issue aims to offer a complex and current overview upon the existent new research topics related to dentistry and oral diseases, expanding the current knowledge and adding important insights related to the management of soft and hard tissue, treatment approaches, and integration of new personalized options for complex oral pathologies.

To contribute to the continuous development in the dentistry field, you can submit your manuscript for this Special Issue.

Prof. Dr. Cosmin Sinescu
Guest Editor

Dr. Ciprian Roi
Prof. Dr. Mircea Riviș
Guest Editor Assistants

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral surgery
  • oral anesthesiology
  • implantology and guided surgery
  • oral tissue regeneration
  • periodontal disease
  • dental materials
  • oral medical devices
  • oral diseases

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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15 pages, 3757 KiB  
Article
Platelet-Rich Fibrin in MRONJ Management: A Prospective Comparative Study on Its Effectiveness in Prevention and Treatment
by Raluca Maracineanu, Anca Tudor, Ivona Hum, Florin Urtila, Felicia Streian, Serban Talpos-Niculescu and Marilena Motoc
Medicina 2025, 61(4), 625; https://doi.org/10.3390/medicina61040625 - 28 Mar 2025
Viewed by 305
Abstract
Background and Objectives: Medication-related osteonecrosis of the jaw (MRONJ) was first recognized as a disease entity and reported in the literature in 2003. Within a few years, the incidence of MRONJ has increased significantly, to the point where now it can be [...] Read more.
Background and Objectives: Medication-related osteonecrosis of the jaw (MRONJ) was first recognized as a disease entity and reported in the literature in 2003. Within a few years, the incidence of MRONJ has increased significantly, to the point where now it can be seen in every dental clinic around the world. Its prevention and management still remain major challenges for dentists and oral and maxillofacial surgeons. Materials and Materials and Methods: This prospective clinical study was conducted at the Oral and Maxillofacial Surgery Clinic in Timisoara for a 6-month period and included a total of 85 patients under chronic antiresorptive and antiangiogenic medication. There were two groups of patients: G1 received PRF growth factors, while the other group, G2, was treated with classical surgical methods. Post-operative wound healing was assessed at 2, 4, and 8 weeks by monitoring the absence of local gingival dehiscence, suprainfection, or loco-regional fistulas, both in cases of dental extractions and sequestrectomies in MRONJ cases. Results: The use of PRF in post-extraction sockets in patients predisposed to developing MRONJ aids in local healing in 96% of cases, compared to cases where it was not used, in which normal healing occurred in only 64.29% of patients; there was a significant difference between the two groups (p = 0.016). In MRONJ confirmed cases, application of PRF after excisional debridement of necrotic bone does not appear to have the same therapeutic value as in post-extractional sockets, with a p-value of 0.299 indicating no statistical significance. Conclusions: PRF use can be considered an effective approach in preventing osteonecrotic complications following dental extractions in patients with antiresorptive treatment. Additional studies are needed to establish its role in MRONJ confirmed cases. Full article
(This article belongs to the Special Issue Advancements in Dental Medicine, Oral Anesthesiology and Surgery)
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11 pages, 1632 KiB  
Article
Comparative Study of Two Root Coverage Procedures for Localized Gingival Recessions on Lower Anterior Teeth Using Partially De-Epithelialized Connective Tissue Graft (PE-CTG) Aided by a High-Speed Handpiece: A Retrospective Cohort Study
by Min-Young Goo, Seung-Kyu Lee, Kyung-Min Kim and Won-Pyo Lee
Medicina 2025, 61(2), 308; https://doi.org/10.3390/medicina61020308 - 10 Feb 2025
Viewed by 909
Abstract
Background and Objectives: Gingival recession is a common periodontal condition that can lead to aesthetic and functional problems if untreated, necessitating the development of effective root coverage techniques. The aim of this study was to compare two different root coverages for localized [...] Read more.
Background and Objectives: Gingival recession is a common periodontal condition that can lead to aesthetic and functional problems if untreated, necessitating the development of effective root coverage techniques. The aim of this study was to compare two different root coverages for localized gingival recession on the lower anterior teeth using a partially de-epithelialized connective tissue graft (PE-CTG). Materials and Methods: This study included 18 patients (20 teeth) with lower anterior tooth recession. In the tPECTG group (seven patients, eight teeth), the recipient site was prepared with supraperiosteal tunneling. In the vPECTG group (11 patients, 12 teeth), the recipient site was prepared using the vestibular incision subperiosteal tunnel access technique. In both groups, partially de-epithelialized connective tissue was harvested from the hard palate using a high-speed handpiece diamond burr. The change in root coverage was evaluated based on vertical recession and keratinized tissue (KT) values before surgery and 6 months after surgery. Results: The mean root coverage was 89.01% across all cases, with the tPECTG and vPECTG groups achieving 87.85% and 89.78%, respectively. The average KT gain was 3.48 ± 1.37 mm, with the tPECTG group showing 3.94 ± 1.74 mm and the vPECTG group showing 3.17 ± 1.03 mm. No significant differences were found between the two groups for either parameter (p > 0.05). Conclusions: Within the limitations of this retrospective case series, vPECTG was as effective as tPECTG, but easier. Moreover, in both groups, the keratinized gingival width increased, and the mucogingival junction was maintained. Full article
(This article belongs to the Special Issue Advancements in Dental Medicine, Oral Anesthesiology and Surgery)
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15 pages, 904 KiB  
Article
Systemic Immune–Inflammatory Index and Other Inflammatory Marker Variations in Oral Squamous Cell Carcinoma Management
by Adrian Nicoară, Ciprian Roi, Alexandra Roi, Alexandru Cătălin Motofelea, Marina Rakitovan, Flavia Zară and Mircea Riviș
Medicina 2024, 60(11), 1840; https://doi.org/10.3390/medicina60111840 - 8 Nov 2024
Cited by 1 | Viewed by 1101
Abstract
Background and Objectives: With the greatest rate of morbidity and death, OSCC is one of the world’s most critical public health problems. Being a complex pathology, the management process that includes diagnostic, surgical, and adjuvant treatments must as well take into account [...] Read more.
Background and Objectives: With the greatest rate of morbidity and death, OSCC is one of the world’s most critical public health problems. Being a complex pathology, the management process that includes diagnostic, surgical, and adjuvant treatments must as well take into account the involvement of the immune system. This study aims to evaluate various biomarkers such as neutrophils, lymphocytes, platelets, SII, and NLR in the different stages of OSCC treatment and in correlation with TNM stages, in order to observe the inflammatory response of the host. Materials and Methods: A total of 154 patients diagnosed with OSCC were included in the present retrospective study. Routine blood samples were collected from all patients both before and after surgery. Using the detected values of platelets, neutrophils, and lymphocyte count, the systemic immune–inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) were calculated. Based on the oncologist’s recommendation, 46 patients underwent adjuvant radiotherapy as part of their oncologic treatment plan. For these patients, additional blood samples were collected before the first and after the last radiotherapy session for determining the values of platelets, neutrophils, and lymphocyte count, and SII and NLR calculation. Results: Prior to the first radiotherapy session, neutrophils decreased slightly to 4.35, lymphocytes increased to 2.23, and platelets rose to 258.62. The SII and NLR were 641.02 and 2.19, respectively. Following the last radiotherapy session, neutrophils increased substantially to 10.30, while lymphocytes decreased to 1.21. Platelets showed a slight reduction to 227.08. Notably, the SII rose dramatically to 3084.19, and the NLR increased significantly to 15.49, suggesting an important immune and inflammatory response of the host. Conclusions: The host’s immunological and inflammatory responses are impacted by both surgery and adjuvant radiation administered following surgery. The parameters assessed—neutrophils, lymphocytes, platelets, SII, and NLR—qualify as significant variables that need to be monitored before, during, and following OSCC therapy. This study’s findings validated significant changes in immunological and inflammatory markers in the management of OSCC. Full article
(This article belongs to the Special Issue Advancements in Dental Medicine, Oral Anesthesiology and Surgery)
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Review

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18 pages, 613 KiB  
Review
Craniocervical Posture and Malocclusion: A Comprehensive Literature Review of Interdisciplinary Insights and Implications
by Andreea Kui, Alexandru Bereanu, Ana-Maria Condor, Dalia Pop, Smaranda Buduru, Anca Labunet, Sebastian Șoicu, Rareș Buduru and Andrea Chisnoiu
Medicina 2024, 60(12), 2106; https://doi.org/10.3390/medicina60122106 - 22 Dec 2024
Cited by 2 | Viewed by 1485
Abstract
Background and Objectives: The impact of craniocervical posture on malocclusion has long intrigued researchers in dentistry, orthodontics, and physical therapy. This research aims to elucidate the relationship between craniocervical posture and both dental and skeletal malocclusions and to explore the potential for [...] Read more.
Background and Objectives: The impact of craniocervical posture on malocclusion has long intrigued researchers in dentistry, orthodontics, and physical therapy. This research aims to elucidate the relationship between craniocervical posture and both dental and skeletal malocclusions and to explore the potential for integrated multidisciplinary therapeutic approaches. Materials and Methods: We analyzed peer-reviewed articles published between 2013 and 2023 from PubMed/Medline, Web of Science, EMBASE, and Scopus. The search strategy included terms related to craniocervical posture and malocclusion, focusing on studies that evaluated the relationship between these conditions before and after various orthodontic or surgical treatments. Results: A total of 20 studies met the inclusion criteria, providing nuanced insights into the interplay between malocclusion types and craniocervical alignment. Findings suggest that altered craniocervical posture is more prevalent in individuals with skeletal malocclusions. In particular, orthodontic treatment and orthognathic surgery appear to influence craniocervical posture, suggesting a bidirectional relationship between craniofacial structure and neck alignment. Conclusions: Our literature review confirms a significant association between craniocervical posture and malocclusion, emphasizing the need for an integrative approach to the diagnosis and treatment of craniofacial anomalies. Future research should aim to quantify these relationships further through longitudinal studies, thereby increasing the understanding necessary to develop comprehensive treatment protocols. Full article
(This article belongs to the Special Issue Advancements in Dental Medicine, Oral Anesthesiology and Surgery)
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