E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Toxicity and Functionalization of Nanomaterials"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials".

Deadline for manuscript submissions: 31 October 2019

Special Issue Editor

Guest Editor
Prof. Rodica Elena Ionescu

University of Technology of Troyes, Charles Delaunay Institute, Laboratory of Light, Nanomaterials and Nanotechnology (L2N), 12 Rue Marie Curie CS 42060, 10004 Troyes Cedex, France
E-Mail
Interests: biosensors; specific biofunctionalization of surfaces; controllable synthesis of nanoparticles; enzymatic nanolithography; toxicity of nanoparticles and water pollutants for living cells and microorganisms

Special Issue Information

Dear colleagues,

Nanomaterials are miniaturized active matrices for the immobilization of chemical and biological entities, contributing to the ultrasentive detection of environmental pollution or medical diagnostics at different levels. On the other hand, nanomaterials are used in the preparation of medicines, cosmetics, food and beverages. Many research groups are focusing on the synthesis of naked and (bio)functionalized metallic and non-metallic nanomaterials of controlled or random shapes and sizes. Nowadays, the potential toxicity of such nanomaterials is poorly explored or even ignored. The aim of this Special Issue is to raise awareness among the scientific community of the urgent need to develop sensitive protocols/tools to rapidly assess the toxicity of nanomaterials and to avoid irreversible changes in human health and biotas.

Articles addressing reproducible, robust and specific (bio)functionalization routes of nanomaterials are welcome. Systematic studies on the toxicity of nanomaterials for living cells and microorganisms are highly solicited.

Prof. Rodica Elena Ionescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Synthesis of nanomaterials
  • (Bio)functionalization of nanomaterials
  • Toxicity of metallic nanoparticles
  • Toxicity of carbonaceous nanoparticles
  • Environmental pollution
  • Medical treatments
  • Cosmetics preparation
  • Food and beverages

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Research

Open AccessArticle Amorphous Silica Nanoparticles Obtained by Laser Ablation Induce Inflammatory Response in Human Lung Fibroblasts
Materials 2019, 12(7), 1026; https://doi.org/10.3390/ma12071026
Received: 20 February 2019 / Revised: 22 March 2019 / Accepted: 25 March 2019 / Published: 28 March 2019
PDF Full-text (4205 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Silica nanoparticles (SiO2 NPs) represent environmentally born nanomaterials that are used in multiple biomedical applications. Our aim was to study the amorphous SiO2 NP-induced inflammatory response in MRC-5 human lung fibroblasts up to 72 hours of exposure. The intracellular distribution of [...] Read more.
Silica nanoparticles (SiO2 NPs) represent environmentally born nanomaterials that are used in multiple biomedical applications. Our aim was to study the amorphous SiO2 NP-induced inflammatory response in MRC-5 human lung fibroblasts up to 72 hours of exposure. The intracellular distribution of SiO2 NPs was measured by transmission electron microscopy (TEM). The lactate dehydrogenase (LDH) test was used for cellular viability evaluation. We have also investigated the lysosomes formation, protein expression of interleukins (IL-1β, IL-2, IL-6, IL-8, and IL-18), COX-2, Nrf2, TNF-α, and nitric oxide (NO) production. Our results showed that the level of lysosomes increased in time after exposure to the SiO2 NPs. The expressions of interleukins and COX-2 were upregulated, whereas the expressions and activities of MMP-2 and MMP-9 decreased in a time-dependent manner. Our findings demonstrated that the exposure of MRC-5 cells to 62.5 µg/mL of SiO2 NPs induced an inflammatory response. Full article
(This article belongs to the Special Issue Toxicity and Functionalization of Nanomaterials)
Figures

Figure 1

Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top