Special Issue "Advanced Polymeric Biomaterials: Preparation, characterization and applications"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Dr. Magdalena Aflori
E-Mail Website
Guest Editor
Petru Poni Institute of Macromolecular Chemistry, Iasi, Romania
Interests: surface modification of polymers; DC and RF plasma; biomaterials; polymer composite; chemical and morphological characterization of polymers
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The rapidly growing field of biomedical engineering has been driven by advances in materials preparation and characterization techniques for target applications. The similarities between natural tissues, proteins, and polymers (either synthetic or natural) with their long-chain architecture lead to the reasonable conclusion that polymers are better representations of natural tissue response compared with metals and ceramics, for example. For these reasons, polymers have attracted a lot of interest, even if their industrial application is prevented by their poor mechanical, thermal and barrier properties. Thus, there is an urgent need for the development of innovative and advanced biomaterials based on natural or synthetic polymers with natural and synthetic additives, both inorganic  and organic, in order to provide improved performance, in terms of cell adhesion, mechanical reinforcement, and antioxidant and antimicrobial features and  to elicit specific biological responses, or to regenerate tissue or organs.

The present Special Issue on “Advanced Polymeric Biomaterials: Preparation, characterisation and applications” welcome contributions in form of full article, short communication, or review article in topics related to the design, synthesis, characterization, surface modification and processing of multifunctional polymeric and composite biomaterials for use in different biomedical applications, including but not limited to medical implants and devices, drug delivery, tissue engineering, and biosensors. This Special Issue represents a good opportunity for chemists, biologists, physicists, pharmacologists, and physicians to put together different aspects of their research that aims to control complex and tunable chemical, mechanical and biological functions in vitro and in vivo.

Dr. Magdalena Aflori
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biopolymers
  • Biomimetic polymers
  • Scaffolds
  • Porous polymers
  • Composite materials
  • Hydrogels
  • Extracellular matrices
  • Surface modification
  • Tissue engineering
  • Micropatterns
  • Regenerative medicine
  • Cell adhesion
  • Cell proliferation
  • Cell–material interaction
  • Biocompatibility
  • Biodegradation
  • Antimicrobial

Published Papers (4 papers)

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Research

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Open AccessArticle
Enzymatically Functionalized Composite Materials Based on Nanocellulose and Poly(Vinyl Alcohol) Cryogel and Possessing Antimicrobial Activity
Materials 2019, 12(21), 3619; https://doi.org/10.3390/ma12213619 - 04 Nov 2019
Abstract
In the present work, innovative composite biomaterials possessing bactericidal properties and based on the hexahistidine-tagged organophosphorus hydrolase (His6-OPH) entrapped in the poly(vinyl alcohol) cryogel (PVA-CG)/bacterial cellulose (BC) were developed. His6-OPH possesses lactonase activity, with a number of N-acyl homoserine [...] Read more.
In the present work, innovative composite biomaterials possessing bactericidal properties and based on the hexahistidine-tagged organophosphorus hydrolase (His6-OPH) entrapped in the poly(vinyl alcohol) cryogel (PVA-CG)/bacterial cellulose (BC) were developed. His6-OPH possesses lactonase activity, with a number of N-acyl homoserine lactones being the inducers of Gram-negative bacterial resistance. The enzyme can also be combined with various antimicrobial agents (antibiotics and antimicrobial peptides) to improve the efficiency of their action. In this study, such an effect was shown for composite biomaterials when His6-OPH was entrapped in PVA-CG/BC together with β-lactam antibiotic meropenem or antimicrobial peptides temporin A and indolicidin. The residual catalytic activity of immobilized His6-OPH was 60% or more in all the composite samples. In addition, the presence of BC filler in the PVA-CG composite resulted in a considerable increase in the mechanical strength and heat endurance of the polymeric carrier compared to the BC-free cryogel matrix. Such enzyme-containing composites could be interesting in the biomedical field to help overcome the problem of antibiotic resistance of pathogenic microorganisms. Full article
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Open AccessArticle
Functional Polyimide-Based Electrospun Fibers for Biomedical Application
Materials 2019, 12(19), 3201; https://doi.org/10.3390/ma12193201 - 29 Sep 2019
Abstract
The current study focuses on the application of cytotoxicity tests upon one membrane matrix based on electrospun polyimide fibers, appealing for biomedical application, such as scaffolds for cell growth, patches or meshes for wound healing, etc. Assays were performed in order to determine [...] Read more.
The current study focuses on the application of cytotoxicity tests upon one membrane matrix based on electrospun polyimide fibers, appealing for biomedical application, such as scaffolds for cell growth, patches or meshes for wound healing, etc. Assays were performed in order to determine the viability and proliferation of L929 murine fibroblasts after they were kept in direct contact with the studied electrospun polyimide fibers. Increased cell viability and proliferation were detected for cells seeded on electrospun polyimide fibers membrane, in comparison with the control system, either after two or six days of evaluation. The number of live cells was higher on the studied material compared to the control, after two and six days of cell seeding. The tendency of the cells to proliferate on the electrospun polyimide fibers was revealed by confocal microscopy. The morphological stability of electrospun polyimide membrane was evaluated by SEM observation, after immersion of the samples in phosphate buffer saline solution (PBS, 7.4 at 37 °C) at various time intervals. Additionally, the easy production of electrospun polyimide fibers can facilitate the development of these types of matrices into specific biomedical applications in the future. Full article
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Open AccessArticle
Seasoning Polymethyl Methacrylate (PMMA) Bone Cements with Incorrect Mix Ratio
Materials 2019, 12(19), 3073; https://doi.org/10.3390/ma12193073 - 20 Sep 2019
Abstract
Cemented joint prostheses are widely used in orthopaedic surgery; however, implants/bone bonds are known to be susceptible to aseptic loosening, particularly in the case of long-term performance. The exact mechanism of this failure is under constant examination. One of the critical factors to [...] Read more.
Cemented joint prostheses are widely used in orthopaedic surgery; however, implants/bone bonds are known to be susceptible to aseptic loosening, particularly in the case of long-term performance. The exact mechanism of this failure is under constant examination. One of the critical factors to the final mechanical functionality of bone cement can be an incorrect mix ratio of a two-component material (powdered polymer and liquid monomer). It can result in the deterioration of the final mechanical strength properties. The paper presents the results from an experimental study on the effects of the deviation from the correct mix ratio on the moisture uptake and the compression strength of cement depending on the seasoning time in Ringer’s solution. The results were subjected to statistical analysis and a mathematical model was developed. Full article
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Review

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Open AccessReview
Biocompatibility of Polyimides: A Mini-Review
Materials 2019, 12(19), 3166; https://doi.org/10.3390/ma12193166 - 27 Sep 2019
Abstract
Polyimides (PIs) represent a benchmark for high-performance polymers on the basis of a remarkable collection of valuable traits and accessible production pathways and therefore have incited serious attention from the ever-demanding medical field. Their characteristics make them suitable for service in hostile environments [...] Read more.
Polyimides (PIs) represent a benchmark for high-performance polymers on the basis of a remarkable collection of valuable traits and accessible production pathways and therefore have incited serious attention from the ever-demanding medical field. Their characteristics make them suitable for service in hostile environments and purification or sterilization by robust methods, as requested by most biomedical applications. Even if PIs are generally regarded as “biocompatible”, proper analysis and understanding of their biocompatibility and safe use in biological systems deeply needed. This mini-review is designed to encompass some of the most robust available research on the biocompatibility of various commercial or noncommercial PIs and to comprehend their potential in the biomedical area. Therefore, it considers (i) the newest concepts in the field, (ii) the chemical, (iii) physical, or (iv) manufacturing elements of PIs that could affect the subsequent biocompatibility, and, last but not least, (v) in vitro and in vivo biocompatibility assessment and (vi) reachable clinical trials involving defined polyimide structures. The main conclusion is that various PIs have the capacity to accommodate in vivo conditions in which they are able to function for a long time and can be judiciously certified as biocompatible. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Surface Characterization and Antibacterial Activity of Au-containing PET Surfaces After Ar Plasma Treatment

Mioara Drobota1, Maria Butnaru1, Nicoleta Vornicu2, Adina Coroaba1, Radu Damian3, Magdalena Aflori1

1- Petru Poni Institute of Macromloecular Chemistry, IAsi, Romania

2-Metropolitan Center of Research T.A.B.O.R, The Metropolitanate of Moldavia and Bukovina, Iasi, Romania

3- SC Intelectro Iasi Srl, Iasi Romania

Coresponding author: Magdalena Aflori

 

Functional Polyimide-based Electrospun Fibers for Biomedical Application

Diana Serbezeanu1, Tăchiță Vlad-Bubulac1, Daniela Rusu1, Grațiela Grădișteanu Pircalabioru2, Iuliana Samoila3, Sorina Dinescu3, Magdalena Aflori1

1- Petru Poni Institute of Macromloecular Chemistry, IAsi, Romania

2-Sanimed International IMPEX SRL, Sos. București Măgurele 70F, București 051434, România

3-Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania

Coresponding author: Diana Serbezeanu

 

Biocompatibility of Polyimides: A Mini-Review

Catalin P. Constantin1, Magdalena Aflori1, Radu Damian2, Radu D. Rusu1

1- Petru Poni Institute of Macromloecular Chemistry, IAsi, Romania

2- SC Intelectro Iasi Srl, Iasi Romania

Coresponding author: Radu D. Rusu

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