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Open AccessArticle

Functional Polyimide-Based Electrospun Fibers for Biomedical Application

“Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda, 41A, 700487 Iasi, Romania
Sanimed International IMPEX SRL, Sos. București Măgurele 70F, 051434 Bucharest, Romania
Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
Authors to whom correspondence should be addressed.
Materials 2019, 12(19), 3201;
Received: 31 August 2019 / Revised: 21 September 2019 / Accepted: 27 September 2019 / Published: 29 September 2019
The current study focuses on the application of cytotoxicity tests upon one membrane matrix based on electrospun polyimide fibers, appealing for biomedical application, such as scaffolds for cell growth, patches or meshes for wound healing, etc. Assays were performed in order to determine the viability and proliferation of L929 murine fibroblasts after they were kept in direct contact with the studied electrospun polyimide fibers. Increased cell viability and proliferation were detected for cells seeded on electrospun polyimide fibers membrane, in comparison with the control system, either after two or six days of evaluation. The number of live cells was higher on the studied material compared to the control, after two and six days of cell seeding. The tendency of the cells to proliferate on the electrospun polyimide fibers was revealed by confocal microscopy. The morphological stability of electrospun polyimide membrane was evaluated by SEM observation, after immersion of the samples in phosphate buffer saline solution (PBS, 7.4 at 37 °C) at various time intervals. Additionally, the easy production of electrospun polyimide fibers can facilitate the development of these types of matrices into specific biomedical applications in the future. View Full-Text
Keywords: electrospun polyimide fibers; dermal fibroblasts; MTT test; Live-Dead test; antimicrobial properties; anti-biofilm activity electrospun polyimide fibers; dermal fibroblasts; MTT test; Live-Dead test; antimicrobial properties; anti-biofilm activity
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Serbezeanu, D.; Vlad-Bubulac, T.; Rusu, D.; Grădișteanu Pircalabioru, G.; Samoilă, I.; Dinescu, S.; Aflori, M. Functional Polyimide-Based Electrospun Fibers for Biomedical Application. Materials 2019, 12, 3201.

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