Special Issue "Nanotoxicology"
A special issue of Materials (ISSN 1996-1944).
Deadline for manuscript submissions: closed (31 July 2012).
Interests: metal and metal oxide nanoparticles; nanotoxicity of metal/metal oxide nanoparticles; oxidative stress; protein modifications by oxidative stress; proteomics; neurotoxicity; in vitro assays; visualisation methods for nanoparticles in biological material; in situ analtics for nanoparticles; nanoparticle protein corona
Interests: xenobiotic phototoxicity; hepatotoxicity and tumorigenicity; DNA or protein adducts; synthesis & characterization DNA/RNA/LNA/PNA; PDT (Photodynamic therapy); cyclodextrins
Investigation of the toxicity of nanomaterials is defined as “nanotoxicology”, which came into being with the occurrence of term “nanomaterial”. Compared to their large counterparts, nanoparticles (< 100 nm) have higher chemical reactivity and bioactivity, better solubility, readiness to gain entry to biological membrane and human body, due to their quantum size effects and surface area to volume ratios. Some nanoparticles, naturally and non-naturally occurring, are known to be dangerous to human or environment and cause pathogenic effects such as oxidative stress, overload of body's phagocytes, inflammation, damages to protein and DNA, DNA mutation. Along with the worldwide development and application of nanomaterials, the concern of nanoparticles to human health safety is mounting. However, there is no authority to regulate nanoparticles to date because of the diversity and structural complexity of nanomaterials.
In this special issue, we focus on the deleterious biological effects of nanomaterials (i.e. nano-C60, carbon nanotubes, nanoparticles of metal and metaloxides, nanoparticles dispersing in atmosphere, lab-prepared functionalized nanoparticles). This issue invites papers ranging from cell toxicity, hepatotoxicity, pneumotoxicity, neurotoxicity, genotoxicity, immunogenicity to the occupation and population as well as controlled clinical study of nanoparticles.
Dr. Andrea Haase
Dr. Yuewei Zhao
- ROS generation
- DNA mutation
- environmental toxicology
- carbon nanotube