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Special Issue "Magnetic Nanoparticles for Biomedical Applications"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials".

Deadline for manuscript submissions: 30 November 2019

Special Issue Editors

Guest Editor
Dr. Fernando Herranz

Nanomedicine and Molecular Imaging group, Instituto de Química Médica – CSIC and CIBERES, Madrid, Spain
Website | E-Mail
Interests: nanomedicine; molecular imaging; iron oxide nanoparticles; atherosclerosis
Guest Editor
Dr. Juan Pellico

Department of Chemistry, University of Oxford,Physical and Theoretical Chemistry Laboratory, Oxford, UK
Website | E-Mail
Interests: nanomedicine; contrast agents; magnetic resonance imaging; molecular imaging; bioconjugation

Special Issue Information

Dear Colleagues,

Magnetic nanoparticles, that we can define as particles responsive to external magnetic fields, are among the most used materials in biomedicine. In nanomedicine, their use is expanding from biosensing to treatment and diagnosis, involving many aspects of the clinical routine. From a more basic point of view, research has focused on new synthetic methods with increased repoducibility and yield. Features like core composition and morphology, coating composition and structure are key to define their physicochemical properties. These properties determine their final use. Magnetic nanoparticles are fundamental in techniques such as magnetic resonance imaging (MRI), magnetic particle imaging (MPI) and hyperthermia, to name but a few. Their importance is also growing for other techniques, such as positron emission tomography (PET) and optoacoustic imaging. Finally, for their application in biomedicine, it is necessary to achieve a deep characterisation of their interactions with different biomolecules in vivo, i.e. to study the protein corona that surrounds them once in vivo.

This Special Issue is devoted to any biomedical application where the use of magnetic nanoparticle is key, as well as to their synthesis, characterisation, and bioconjugation.

Potential topics include but are not limited to the following:

  • Magnetic nanoparticles as MRI probes
    (T1 and/or T2)
  • Magnetic nanoparticles as in vitro sensors
  • Hyperthermia
  • Magnetic particle imaging
  • Magnetic nanoparticles in nuclear imaging techniques
  • New synthetic methods
  • Bioconjugation of magnetic nanoparticles for bioimaging
  • Protein corona and magnetic nanoparticles

Dr. Fernando Herranz
Dr. Juan Pellico
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • magnetic imaging
  • magnetic nano-radiotracers
  • bioconjugation
  • protein corona

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Use of a Bioengineered Antioxidant in Mouse Models of Metabolic Syndrome"

Deric M. Griffin, Brittany R. Bitner, Zachary Criss II, Daniela Marcano, Jacob M. Berlin, Thomas A. Kent, Susan L. Samson, James M. Tour *, and Robia G. Pautler *

Background: Metabolic syndrome (MetS) is a group of conditions that increase the risk of developing heart disease, stroke and type-2 diabetes and is present in 35% of US adults. Oxidative stress has been implicated in MetS, however, antioxidants such as vitamin E have had limited success in the clinic. This prompts the question of what effects a more potent antioxidant might produce. A prime candidate is the recently developed bioengineered antioxidant, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs), which is capable of neutralizing the reactive oxygen species (ROS) superoxide anion and hydroxyl radical at 106/molecule of PEG-HCC.

Results: PEG-HCC treatment lessened lipid peroxidation, aspartate aminotransferase levels, non[fasting blood glucose levels and JNK phosphorylation in ob/ob mice. PEG-HCC treated WT mice had an increased response to insulin by ITT and a decrease in blood glucose by GTT. These effects were not observed in HFD-fed mice, regardless of treatment. PEG-HCCs were observed in the interstitial space of liver, spleen, skeletal muscle and adipose tissue. No significant difference was shown in gluconeogenesis or inflammatory gene expression between treatment and dietary groups.

Conclusions: PEG-HCC can improve some parameters of disease in these models and this may be due to a resulting increase in peripheral insulin sensitivity. However, additional studies are needed to elucidate how PEG-HCCs are producing these effects.

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