Magnetic Nanoparticles Supporting Bio-responsive T1/T2 Magnetic Resonance Imaging
Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK
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Materials 2019, 12(24), 4096; https://doi.org/10.3390/ma12244096
Received: 12 November 2019 / Revised: 29 November 2019 / Accepted: 2 December 2019 / Published: 7 December 2019
(This article belongs to the Special Issue Nanoparticles for Biomedical Applications)
The use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monitoring of disease progression/response to treatment. In this review, magnetic nanoparticles that exhibit a bio-responsive MR relaxivity are discussed, with pH-, enzyme-, biomolecular-, and protein-responsive systems considered. The ability of a contrast agent to respond to a biological stimulus provides not only enriched diagnostic capabilities over corresponding non-responsive analogues, but also an improved longitudinal monitoring of specific physiological conditions.
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Keywords:
Bio-responsive; Nanoparticle; pH-responsive; Enzyme-responsive; Biomolecule-responsive; Magnetic Resonance Imaging; Diagnosis; Therapy; Mesoporous Silica Nanoparticles; Iron Oxide Nanoparticles
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MDPI and ACS Style
Ellis, C.M.; Pellico, J.; Davis, J.J. Magnetic Nanoparticles Supporting Bio-responsive T1/T2 Magnetic Resonance Imaging. Materials 2019, 12, 4096.
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