Special Issue "Advanced Functional Nanostructured Biosensors"

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: 29 February 2020.

Special Issue Editor

Prof. Dr. Valber de Albuquerque Pedrosa
E-Mail Website
Guest Editor
UNESP-Universidade Estadual Paulista, Sao Paulo, Brazil
Interests: sensor; biosensor; microfluidcs systems; nanoparticles

Special Issue Information

Dear Colleagues,

Nanomaterials have shown tremendous potential to impact the broad biological/chemical field. The unique properties of nanomaterial provide appropriate surface modifications, which allow intimate interaction with target biomolecules. The detection mechanism is based on the conversion of target binding events into physical signals that can be amplified and detected. The Special Issue “Advanced Functional Nanostructured Biosensor” aims to identify new trends of manufacturing and application of these structures in ferroelectric materials, catalytic materials, optic, magnetic, thermoelectric, piezoelectric, electrochemical, quantum dots, micro-RNA, carbon structures, and other related advanced functional materials. 
It is my pleasure to invite you to submit a manuscript to this Special Issue. Submissions of communications, full papers, and reviews are all welcome.

Prof. Dr. Valber de Albuquerque Pedrosa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanomaterials
  • Naked eye detection
  • Carbon nanotube
  • Graphene
  • Nanoplasmonic
  • Biomimetic

Published Papers (1 paper)

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Research

Open AccessArticle
Anti-EGFR-Coated Gold Nanoparticles In Vitro Carry 5-Fluorouracil to Colorectal Cancer Cells
Materials 2020, 13(2), 375; https://doi.org/10.3390/ma13020375 - 14 Jan 2020
Abstract
The aim of the current study is to present a strategy to improve the efficiency of 5-fluorouracil (5-FU), which is widely used as antineoplastic agent against solid tumors-based on the use of gold nanocarriers to overcome the resistance of colorectal cancer cells. 5-FU [...] Read more.
The aim of the current study is to present a strategy to improve the efficiency of 5-fluorouracil (5-FU), which is widely used as antineoplastic agent against solid tumors-based on the use of gold nanocarriers to overcome the resistance of colorectal cancer cells. 5-FU was loaded on gold nanoparticles (AuNP) coated with anti-EGFR antibodies in order to target them towards colorectal cancer cells that overexpress epidermal growth factor receptors (EGFR). Physicochemical characterization has shown that AuNP size was approximately 20 nm and that AuNP functionalization led to spherical nanoparticles. Flow cytometry allowed observing that some compounds synthesized by our research group have induced apoptosis/necrosis and impaired the proliferation of colon cancer cell lines ‘HCT-116′ and ‘HT-29′. The antibody/drug combination in AuNP (AuNP 5FU EGFR) has improved the apoptosis rate and impaired cell proliferation in both cell lines, regardless of the exposure time. Overall, these results have shown that AuNP functionalization with monoclonal antibodies focused on delivering 5-FU to tumor cells is an exciting strategy against colorectal cancer. Full article
(This article belongs to the Special Issue Advanced Functional Nanostructured Biosensors)
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