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Bioceramics: Materials, Properties and Applications (Second Volume)

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 August 2023) | Viewed by 1961

Special Issue Editor


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Guest Editor
Université de Reims Champagne-Ardenne, EA 4691 BIOS, 51 Rue Cognacq Jay, 51100 Reims, France
Interests: bone; ceramics; inflammation; in vitro; in vivo
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of bioceramics is constantly growing. The main applications of bioceramics address the topics of drug delivery and tissue regeneration, especially for hard tissues such as teeth and bones. Thanks to new engineering approaches, the reconstruction of human tissues is becoming a reality, yet many fundamental problems remain to be solved for hard tissues such as bone. One of them is the requirement of adequate scaffold able to support, promote, and stimulate tissue ingrowth. New synthesis routes and functionalization, as well as original manufacturing processes, may help to overcome these limitations. Many avenues have to be explored to develop new bioceramics with properties intended to favor biological tissue regeneration. More new materials may lead to original applications for bioceramics. Therefore, this Special Issue of Materials will collect original, high-quality research papers covering the most recent advances and comprehensive reviews addressing state-of-the-art topics in the field of bioceramics materials, their properties, and their application systems for current and futuristic biomedical applications.

Dr. Frédéric Velard
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioceramics
  • synthesis
  • doping elements
  • manufacturing
  • characterization
  • biological activity
  • 3D scaffolds
  • biocompatibility
  • inflammation
  • infection
  • regenerative properties

Published Papers (2 papers)

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Research

11 pages, 4694 KiB  
Article
Evaluation of Cytotoxicity, Cell Attachment, and Elemental Characterization of Three Calcium Silicate-Based Sealers
by Anahi de Paula Melo, Camila Maria Peres de Rosatto, Danilo Cassiano Ferraz, Gabriela Leite de Souza and Camilla Christian Gomes Moura
Materials 2023, 16(20), 6705; https://doi.org/10.3390/ma16206705 - 16 Oct 2023
Cited by 2 | Viewed by 801
Abstract
We investigated three calcium silicate-based sealers with respect to their chemical characterization, cytotoxicity, and attachment to RAW264.7 cells. BioRoot RCS (BR), Bio-C Sealer (BC), and Sealer Plus BC (SPBC) were assessed using Fourier transform infrared spectroscopy (FTIR), X-ray fluorescence spectroscopy (XRF), and energy-dispersive [...] Read more.
We investigated three calcium silicate-based sealers with respect to their chemical characterization, cytotoxicity, and attachment to RAW264.7 cells. BioRoot RCS (BR), Bio-C Sealer (BC), and Sealer Plus BC (SPBC) were assessed using Fourier transform infrared spectroscopy (FTIR), X-ray fluorescence spectroscopy (XRF), and energy-dispersive X-ray spectroscopy (EDX) (n = 4) for elemental characterization, and using scanning electron microscopy (SEM) to evaluate cell morphology and adhesion. Cytotoxicity was determined at different dilutions (1:1, 1:2, and 1:5) using the succinate dehydrogenase activity (MTT assay). Statistical analysis was performed for normal distribution using the Shapiro–Wilk test and for homoscedasticity using Levene’s test, and one-way ANOVA, Tukey’s/Dunnett’s post hoc tests for cell viability and XRF (α = 0.05). Calcium silicate hydrate and calcium hydroxide were detected by FTIR in all groups. EDX detected a higher calcium content for BR and SPBC and aluminum only in the premixed sealers. XRF detected the highest calcium release in BR (p < 0.05). The surface morphology showed irregular precipitates for all the sealers. SPBC at a 1:2 dilution resulted in the lowest cell viability compared to BR (p < 0.05) and BC (p < 0.05). The calcium silicate-based sealers produced a statistically significant reduction in cellular viability at a 1:1 dilution compared to the control group (p < 0.0001). All the sealers maintained viability above 70%. Full article
(This article belongs to the Special Issue Bioceramics: Materials, Properties and Applications (Second Volume))
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11 pages, 17660 KiB  
Article
Investigation of the Damage Phenomenology with Dependence on the Macroporosity and Microporosity of Porous Freeze Foams
by Johanna Maier, David Werner, Vinzenz Geske, Thomas Behnisch, Mathias Ahlhelm, Tassilo Moritz, Alexander Michaelis and Maik Gude
Materials 2023, 16(6), 2484; https://doi.org/10.3390/ma16062484 - 21 Mar 2023
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Abstract
Freeze Foams are cellular, ceramic structures with hierarchical pore structures that are manufactured using the direct foaming process. By tailoring their morphology and strength, these foam structures are able to cover a wide range of application. Earlier works identified that pore-forming influencing factors [...] Read more.
Freeze Foams are cellular, ceramic structures with hierarchical pore structures that are manufactured using the direct foaming process. By tailoring their morphology and strength, these foam structures are able to cover a wide range of application. Earlier works identified that pore-forming influencing factors (water and air content, suspension temperature, as well as pressure reduction rate) dictate the constitution on a macroscopic and microscopic scale. Therefore, the ability to manufacture foams whose properties align with the component requirements would be an important step in advancing towards a widespread application of these promising materials. With this goal in mind, the correlation between the pore-forming influencing factors and the resulting mechanical properties was quantified. Foams with independently adjustable porosities were produced at the micro and macro scales and evaluated according to their material failure behavior under compressive loads. As a result, foams with determined macroporosities between 38 and 62%, microporosities between 25 and 42%, and compression strengths between 1 and 7 MPa with different material failure characteristics were manufactured and systematically investigated. Full article
(This article belongs to the Special Issue Bioceramics: Materials, Properties and Applications (Second Volume))
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