Special Issue "Marine Antibiotics 2020"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (5 February 2021) | Viewed by 15386
Interests: antibiotics from marine microbiota; antibiofilm; gram negative pathogens; antimicrobial peptides
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Special Issue in Antibiotics: New Antibiotic Compounds: Discovery and Strategies
At the outset of the antibiotic era, as early as 1945, A. Fleming warned against the bacterial resistance induced by antibiotic under-dosing during his Nobel Prize lecture on penicillin discovery. He announced nothing less than the post-antibiotic era. Since 1945, the abusive and/or incorrect antibiotic uses combined with the lack of renewal of antibiotic compounds in the clinical armamentarium have constituted a ticking time bomb. Indeed, antibiotic misuse has resulted in the selection of bacteria exhibiting multidrug resistance (MDR), extensive drug resistance (XDR), and pandrug resistance (PDR). Nowadays, antimicrobial resistance (AMR) has become a global public health threat. It is expected to be one of the leading causes of death in the world in 2050. Faced with these dire predictions, a plethora of actions, networks, and calls for projects have been implemented nationally and internationally. Obviously, learning from errors, the prevention of antibiotic misuses, resistance detection and diagnosis, and achieving public awareness are leverage actions with which to fight antimicrobial resistance. However, it is clear that the renewal of the therapeutic arsenal is a major priority, if only to treat patients.
Marine organisms are still under-explored at the biochemical level. The hologenome theory of evolution and the advent of new generation DNA sequencing have highlighted the intimate relationships between microbiota and host in cnidarian and sponges. Although the way a host controls or is controlled by its microbiota remains to be clarified, marine holobionts still represent a mine of innovative compounds and a source of inspiration with which to design potent and effective drugs to combat AMR.
The first Special Issue dedicated to marine antibiotics was managed by Prof. Sergey Zotchev in 2012. It assembled 11 papers, which have collected, to date, 247 citations (according to the Web of Science). More than an update, I would like this Special Issue to aggregate innovative data regarding marine antibiotics, whatever their origin (archeabacteria, eubacteria, algae, animals, or even metagenomic data mining), biosynthesis, chemical nature (PKS, NRPS, peptides, alkaloids, etc.), or mechanisms of actions. Original research as well as review articles are welcome. Scientists are invited to contribute in order to combine expertise in (meta)data mining, microbiology, biochemistry, biotechnology, cellular biology, and medicine.
Dr. Yannick Fleury
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.