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Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii

Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Departamento de Química Orgánica, Universidad de La Laguna (ULL), Avda. Astrofísico F. Sánchez, 2, 38206 La Laguna, Tenerife, Spain
Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), Av. Pedro de Alba s/n, 66450 San Nicolás de los Garza, Nuevo León, Mexico
Servicio de Dermatología, Hospital Universitario “José E. González”, Universidad Autónoma de Nuevo León (UANL), Madero y Gonzalitos, Col. Mitras Centro, 64460 Monterrey, Nuevo León., Mexico
Centro de Investigación Biomédica del Noreste (CIBIN), Instituto Mexicano del Seguro Social (IMSS), Calle Jesús Dionisio González # 501, Col. Independencia, 64720 Monterrey, Nuevo León, Mexico
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(6), 287;
Received: 5 May 2020 / Revised: 20 May 2020 / Accepted: 29 May 2020 / Published: 30 May 2020
(This article belongs to the Special Issue Marine Antibiotics 2020)
Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discovered bioactive metabolites but also on already known compounds not yet thoroughly investigated. Since drug resistance has caused an increase in infections by Mycobacterium tuberculosis and nontuberculous mycobacteria, the re-evaluation of known bioactive metabolites has been suggested as a good approach to addressing this problem. In this sense, this study presents an evaluation of the in vitro effect of laurinterol and aplysin, two brominated sesquiterpenes isolated from Laurencia johnstonii, against nine M. tuberculosis strains and six nontuberculous mycobacteria (NTM). Laurinterol exhibited good antimycobacterial activity, especially against nontuberculous mycobacteria, being remarkable its effect against Mycobacterium abscessus, with minimum inhibitory concentration (MIC) values lower than those of the reference drug imipenem. This study provides further evidence for the antimycobacterial activity of some sesquiterpenes from L. johnstonii, which can be considered interesting lead compounds for the discovery of novel molecules to treat NTM infections. View Full-Text
Keywords: marine natural products; Laurencia; brominated sesquiterpenes; antimycobacterial; nontuberculous mycobacteria; tuberculosis marine natural products; Laurencia; brominated sesquiterpenes; antimycobacterial; nontuberculous mycobacteria; tuberculosis
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MDPI and ACS Style

García-Davis, S.; Leal-López, K.; Molina-Torres, C.A.; Vera-Cabrera, L.; Díaz-Marrero, A.R.; Fernández, J.J.; Carranza-Rosales, P.; Viveros-Valdez, E. Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii. Mar. Drugs 2020, 18, 287.

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