Pharmaceutical, Nutraceutical, Cosmeceutical and Biotechnological Potentials of Southeast Asian Marine Resources

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 18890

Special Issue Editors


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Guest Editor
Research Center for Biotechnology, Research Center for Life Sciences, National Research and Innovation Agency (BRIN), Cibinong, Indonesia
Interests: marine natural products

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Guest Editor
Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand
Interests: marine natural products

Special Issue Information

Dear Colleagues,

The oceans encompass about 70% of the surface of our planet, and they represent the greatest extremes of temperatures, light, and pressure encountered by life, thus providing diverse environmental niches. The marine environment is mainly underexplored and untapped compared to the terrestrial environment, which makes it attractive and challenging. Hence, research efforts to discover bioactive secondary metabolites have expanded from land to the oceans. A myriad of novel secondary metabolites with unique scaffolds have been reported in recent years, many of which have revealed great potential for pharmaceutical, cosmeceutical, nutraceutical, and biotechnological applications. Although marine invertebrates—mainly sponges, soft corals, and ascidians—initially dominated these studies, partly because they are easily accessible to collectors by snorkeling or scuba diving, recently many researchers have focused on marine microorganisms as interesting sources of secondary metabolites with a wide array of biological/pharmacological activities and biotechnological potential.

Southeast Asia is the largest archipelago region, consisting of more than 25,000 islands and thousands of kilometers of coastline, and is recognized as a global marine biodiversity hotspot. Its extraordinary biodiversity makes this region a promising source of new bioactive compounds for pharmaceutical, nutraceutical, cosmeceutical, and biotechnological development.

The Special Issue "Pharmaceutical, Nutraceutical, Cosmeceutical, and Biotechnological Applications of Marine Resources in Southeast Asia" welcomes submissions of previously unpublished manuscripts from original work on isolation, structure elucidation, and biological activity evaluation, in vitro and in vivo pharmacological study of marine-derived compounds, marine natural products with insecticidal or herbicidal activities, and synthesis and medicinal chemistry of marine natural products from marine macro- or microorganisms collected from Southeast Asian waters.

Please note that reports of known compounds from new sources will not generally be accepted unless they have relevant biological and pharmacological activities. Moreover, extracts of marine macro- or microorganisms used in vitro and/or in vivo pharmacological study must be characterized by analysis of their major constituents (e.g. HPLC fingerprints, HPLC-MS, GC-MS, or NMR analyses). The editorial team of this Special Issue plans to receive full paper submissions from 1st February 2022 to 30th June 2022. 

Prof. Dr. Anake Kijjoa
Dr. Masteria Yunovilsa Putra
Dr. Tida Dethoup
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (7 papers)

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Research

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14 pages, 330 KiB  
Article
Exploring Bioactive Compounds in Brown Seaweeds Using Subcritical Water: A Comprehensive Analysis
by Jin-Seok Park, Ji-Min Han, Yu-Na Shin, Ye-Seul Park, Ye-Ryeon Shin, Sin-Won Park, Vikash Chandra Roy, Hee-Jeong Lee, Yuya Kumagai, Hideki Kishimura and Byung-Soo Chun
Mar. Drugs 2023, 21(6), 328; https://doi.org/10.3390/md21060328 - 26 May 2023
Cited by 8 | Viewed by 2135
Abstract
In this study, we characterized the bioactive properties of three important brown seaweed species, Sargassum thunbergii, Undaria pinnatifida, and Saccharina japonica, by subcritical water extraction (SWE), as these species are well known for their beneficial health effects. Their physiochemical properties, [...] Read more.
In this study, we characterized the bioactive properties of three important brown seaweed species, Sargassum thunbergii, Undaria pinnatifida, and Saccharina japonica, by subcritical water extraction (SWE), as these species are well known for their beneficial health effects. Their physiochemical properties, including potential antioxidant, antihypertensive, and α-glucosidase inhibitory activity, and the antibacterial activity of the hydroysates were also analyzed. The highest total phlorotannin, total sugar content, and reducing sugar content in the S. thunbergii hydrolysates were 38.82 ± 0.17 mg PGE/g, 116.66 ± 0.19 mg glucose/g dry sample, and 53.27 ± 1.57 mg glucose/g dry sample, respectively. The highest ABTS+ and DPPH antioxidant activities were obtained in the S. japonica hydrolysates (124.77 ± 2.47 and 46.35 ± 0.01 mg Trolox equivalent/g, respectively) and the highest FRAP activity was obtained in the S. thunbergii hydrolysates (34.47 ± 0.49 mg Trolox equivalent/g seaweed). In addition, the seaweed extracts showed antihypertensive (≤59.77 ± 0.14%) and α-glucosidase inhibitory activity (≤68.05 ± 1.15%), as well as activity against foodborne pathogens. The present findings provide evidence of the biological activity of brown seaweed extracts for potential application in the food, pharmaceutical, and cosmetic sectors. Full article
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10 pages, 2761 KiB  
Article
Effect of Storage Time and Temperature on the Bioactivity of a Chitosan-Derived Epigenetic Modulation Scaffold
by Teerawat Sukpaita, Suwabun Chirachanchai, Atiphan Pimkhaokham and Ruchanee Salingcarnboriboon Ampornaramveth
Mar. Drugs 2023, 21(3), 175; https://doi.org/10.3390/md21030175 - 12 Mar 2023
Cited by 2 | Viewed by 1365
Abstract
The appropriate storage protocol is one of the main limitations of translating tissue engineering technology to commercialized clinical applications. Recently, the development of a chitosan-derived composite scaffold incorporated with bioactive molecules has been reported as an excellent material to repair a critical size [...] Read more.
The appropriate storage protocol is one of the main limitations of translating tissue engineering technology to commercialized clinical applications. Recently, the development of a chitosan-derived composite scaffold incorporated with bioactive molecules has been reported as an excellent material to repair a critical size bony defect in mice calvaria. This study aims to determine the storage time and appropriate storage temperature of Chitosan/Biphasic Calcium Phosphate/Trichostatin A composite scaffold (CS/BCP/TSA scaffold) in vitro. The mechanical properties and in vitro bioactivity of trichostatin A (TSA) released from CS/BCP/TSA scaffolds in different storage times and temperatures were evaluated. Different storage times (0, 14, and 28 days) and temperatures (−18, 4, and 25 °C) did not affect the porosity, compressive strength, shape memory, and amount of TSA released. However, scaffolds stored at 25 °C and 4 °C were found to lose their bioactivity after 3- and 7-day storage periods, respectively. Thus, the CS/BCP/TSA scaffold should be stored in freezing conditions to preserve the long-term stability of TSA. Full article
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14 pages, 4610 KiB  
Article
Dieckol Isolated from Eisenia bicyclis Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice
by Jae-Min Kim, Kyung-Sook Chung, Young-Seo Yoon, Seo-Yun Jang, So-Won Heo, Geonha Park, Young-Pyo Jang, Hye-Shin Ahn, Yu-Kyong Shin, Sun-Hee Lee and Kyung-Tae Lee
Mar. Drugs 2022, 20(12), 779; https://doi.org/10.3390/md20120779 - 14 Dec 2022
Cited by 7 | Viewed by 1718
Abstract
Repetitive exposure to ultraviolet B (UVB) is one of the main causes of skin photoaging. We previously reported that dieckol isolated from Eisenia bicyclis extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells. Here, we aimed to evaluate the anti-photoaging activity of dieckol [...] Read more.
Repetitive exposure to ultraviolet B (UVB) is one of the main causes of skin photoaging. We previously reported that dieckol isolated from Eisenia bicyclis extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells. Here, we aimed to evaluate the anti-photoaging activity of dieckol in a UVB-irradiated hairless mouse model. In this study, hairless mice were exposed to UVB for eight weeks. At the same time, dieckol at two doses (5 or 10 mg/kg) was administered orally three times a week. We found that dieckol suppressed UVB-induced collagen degradation and matrix metalloproteinases (MMPs)-1, -3, and -9 expression by regulating transforming growth factor beta (TGF-β)/Smad2/3 and mitogen-activated protein kinases (MAPKs)/activator protein-1 (AP-1) signaling. In addition, dieckol rescued the production of hyaluronic acid (HA) and effectively restored the mRNA expression of hyaluronan synthase (HAS)-1/-2 and hyaluronidase (HYAL)-1/-2 in UVB-irradiated hairless mice. We observed a significant reduction in transepidermal water loss (TEWL), epidermal/dermal thickness, and wrinkle formation in hairless mice administered dieckol. Based on these results, we suggest that dieckol, due to its anti-photoaging role, may be used as a nutricosmetic ingredient for improving skin health. Full article
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22 pages, 5238 KiB  
Article
Potential of Epidermal Growth Factor-like Peptide from the Sea Cucumber Stichopus horrens to Increase the Growth of Human Cells: In Silico Molecular Docking Approach
by Nur Shazwani Mohd Pilus, Azira Muhamad, Muhammad Ashraf Shahidan and Nurul Yuziana Mohd Yusof
Mar. Drugs 2022, 20(10), 596; https://doi.org/10.3390/md20100596 - 23 Sep 2022
Cited by 2 | Viewed by 2077
Abstract
The sea cucumber is prominent as a traditional remedy among Asians for wound healing due to its high capacity for regeneration after expulsion of its internal organs. A short peptide consisting of 45 amino acids from transcriptome data of Stichopus horrens (Sh-EGFl-1) shows [...] Read more.
The sea cucumber is prominent as a traditional remedy among Asians for wound healing due to its high capacity for regeneration after expulsion of its internal organs. A short peptide consisting of 45 amino acids from transcriptome data of Stichopus horrens (Sh-EGFl-1) shows a convincing capability to promote the growth of human melanoma cells. Molecular docking of Sh-EGFl-1 peptide with human epidermal growth factor receptor (hEGFR) exhibited a favorable intermolecular interaction, where most of the Sh-EGFl-1 residues interacted with calcium binding-like domains. A superimposed image of the docked structure against a human EGF–EGFR crystal model also gave an acceptable root mean square deviation (RMSD) value of less than 1.5 Å. Human cell growth was significantly improved by Sh-EGFl-1 peptide at a lower concentration in a cell proliferation assay. Gene expression profiling of the cells indicated that Sh-EGFl-1 has activates hEGFR through five epidermal growth factor signaling pathways; phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), phospholipase C gamma (PLC-gamma), Janus kinase-signal transducer and activator of transcription (JAK-STAT) and Ras homologous (Rho) pathways. All these pathways triggered cells’ proliferation, differentiation, survival and re-organization of the actin cytoskeleton. Overall, this marine-derived, bioactive peptide has the capability to promote proliferation and could be further explored as a cell-growth-promoting agent for biomedical and bioprocessing applications. Full article
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Review

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26 pages, 2681 KiB  
Review
Secondary Metabolites from Marine-Derived Bacteria with Antibiotic and Antibiofilm Activities against Drug-Resistant Pathogens
by Joko Tri Wibowo, Asep Bayu, Widya Dwi Aryati, Carla Fernandes, Arry Yanuar, Anake Kijjoa and Masteria Yunovilsa Putra
Mar. Drugs 2023, 21(1), 50; https://doi.org/10.3390/md21010050 - 12 Jan 2023
Cited by 8 | Viewed by 3889
Abstract
The search for new antibiotics against drug-resistant microbes has been expanded to marine bacteria. Marine bacteria have been proven to be a prolific source of a myriad of novel compounds with potential biological activities. Therefore, this review highlights novel and bioactive compounds from [...] Read more.
The search for new antibiotics against drug-resistant microbes has been expanded to marine bacteria. Marine bacteria have been proven to be a prolific source of a myriad of novel compounds with potential biological activities. Therefore, this review highlights novel and bioactive compounds from marine bacteria reported during the period of January 2016 to December 2021. Published articles containing novel marine bacterial secondary metabolites that are active against drug-resistant pathogens were collected. Previously described compounds (prior to January 2016) are not included in this review. Unreported compounds during this period that exhibited activity against pathogenic microbes were discussed and compared in order to find the cue of the structure–bioactivity relationship. The results showed that Streptomyces are the most studied bacteria with undescribed bioactive compounds, followed by other genera in the Actinobacteria. We have categorized the structures of the compounds in the present review into four groups, based on their biosynthetic origins, as polyketide derivatives, amino acid derivatives, terpenoids, as well as compounds with mixed origin. These compounds were active against one or more drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), vancomycin-resistant Enterococci (VRE), multidrug-resistant Mycobacterium tuberculosis (MDR-TB), and amphotericin B-resistant Candida albicans. In addition, some of the compounds also showed activity against biofilm formation of the test bacteria. Some previously undescribed compounds, isolated from marine-derived bacteria during this period, could have a good potential as lead compounds for the development of drug candidates to overcome multidrug-resistant pathogens. Full article
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36 pages, 4824 KiB  
Review
Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles
by Hanaa Ali Hussein, Muhammad Shahid Nazir, Nizakat Azra, Zeenat Qamar, Azman Seeni, Tengku Ahmad Damitri Al-Astani Tengku Din and Mohd Azmuddin Abdullah
Mar. Drugs 2022, 20(8), 480; https://doi.org/10.3390/md20080480 - 27 Jul 2022
Cited by 10 | Viewed by 3671
Abstract
Mesoporous silica nanoparticles (MSNs) have great potential for applications as a drug delivery system (DDS) due to their unique properties such as large pore size, high surface area, biocompatibility, biodegradability, and stable aqueous dispersion. The MSN-mediated DDS can carry chemotherapeutic agents, optical sensors, [...] Read more.
Mesoporous silica nanoparticles (MSNs) have great potential for applications as a drug delivery system (DDS) due to their unique properties such as large pore size, high surface area, biocompatibility, biodegradability, and stable aqueous dispersion. The MSN-mediated DDS can carry chemotherapeutic agents, optical sensors, photothermal agents, short interfering RNA (siRNA), and gene therapeutic agents. The MSN-assisted imaging techniques are applicable in cancer diagnosis. However, their synthesis via a chemical route requires toxic chemicals and is challenging, time-consuming, and energy-intensive, making the process expensive and non-viable. Fortunately, nature has provided a viable alternative material in the form of biosilica from marine resources. In this review, the applications of biosilica nanoparticles synthesized from marine diatoms in the field of drug delivery, biosensing, imaging agents, and regenerative medicine, are highlighted. Insights into the use of biosilica in the field of DDSs are elaborated, with a focus on different strategies to improve the physico-chemical properties with regards to drug loading and release efficiency, targeted delivery, and site-specific binding capacity by surface functionalization. The limitations, as well as the future scope to develop them as potential drug delivery vehicles and imaging agents, in the overall therapeutic management, are discussed. Full article
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69 pages, 21855 KiB  
Review
Anthraquinones and Their Analogues from Marine-Derived Fungi: Chemistry and Biological Activities
by Salar Hafez Ghoran, Fatemeh Taktaz, Seyed Abdulmajid Ayatollahi and Anake Kijjoa
Mar. Drugs 2022, 20(8), 474; https://doi.org/10.3390/md20080474 - 25 Jul 2022
Cited by 20 | Viewed by 4034
Abstract
Anthraquinones are an interesting chemical class of polyketides since they not only exhibit a myriad of biological activities but also contribute to managing ecological roles. In this review article, we provide a current knowledge on the anthraquinoids reported from marine-derived fungi, isolated from [...] Read more.
Anthraquinones are an interesting chemical class of polyketides since they not only exhibit a myriad of biological activities but also contribute to managing ecological roles. In this review article, we provide a current knowledge on the anthraquinoids reported from marine-derived fungi, isolated from various resources in both shallow waters such as mangrove plants and sediments of the mangrove habitat, coral reef, algae, sponges, and deep sea. This review also tentatively categorizes anthraquinone metabolites from the simplest to the most complicated scaffolds such as conjugated xanthone–anthraquinone derivatives and bianthraquinones, which have been isolated from marine-derived fungi, especially from the genera Apergillus, Penicillium, Eurotium, Altenaria, Fusarium, Stemphylium, Trichoderma, Acremonium, and other fungal strains. The present review, covering a range from 2000 to 2021, was elaborated through a comprehensive literature search using the following databases: ACS publications, Elsevier, Taylor and Francis, Wiley Online Library, MDPI, Springer, and Thieme. Thereupon, we have summarized and categorized 296 anthraquinones and their derivatives, some of which showed a variety of biological properties such as enzyme inhibition, antibacterial, antifungal, antiviral, antitubercular (against Mycobacterium tuberculosis), cytotoxic, anti-inflammatory, antifouling, and antioxidant activities. In addition, proposed biogenetic pathways of some anthraquinone derivatives are also discussed. Full article
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