Current and Novel Therapeutic Strategies for Cancers in the Era of Personalized Treatment

Dear Colleagues,

This Special Issue of Life is dedicated to personalized medicine in cancer. The therapeutic strategies currently approved for the treatment of solid tumors include multidisciplinary approaches: surgery, radiotherapy and medical treatment. Over the past decade, huge progress has derived from the introduction of target therapies, immunotherapy and other novel approaches such as epigenetic drugs that have paved the way to more tailored opportunities for cancer treatment. Unfortunately, a high portion of patients with cancer still present poor outcomes, due to the complex molecular heterogeneity of tumors and multiple mechanisms driving therapeutic resistance. In oncology, the use of personalized medicine is the main goal, to transform traditional medical chemotherapy-based anti-cancer treatments into molecularly driven, individualized anti-cancer therapies, based on results from molecular analyses that have entered the mainstream of clinical practice in cancer. Whole DNA sequencing technologies such as next generation sequencing (NGS) have improved the genomic understanding of disease; nevertheless, a multi-omic approach that involves the study of the transcriptome, proteome and metabolome is strongly suggested, to further stratify patients and provide deeper insights into cancers. With this Special Issue, we aim to collect original data from translational research groups and updated reviews of the literature to highlight recent discoveries on personalized medicine in the field of cancer.

Dr. Giulia Martini
Dr. Stefania Napolitano
Dr. Carminia Maria Della Corte
Guest Editors

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