Nutritional Supplements and Cardiovascular Function in Athletes and Sedentary People: 2nd Edition

A special issue of Life (ISSN 2075-1729).

Deadline for manuscript submissions: 8 January 2027 | Viewed by 87

Special Issue Editors


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Guest Editor
1. Scientific Center of Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek, HR-31000 Osijek, Croatia
2. Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, HR-31000 Osijek, Croatia
Interests: microcirculation; n-3 PUFAs; endothelium; oxidative stress; eicosanoids; nutrients; exercise
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Guest Editor
1. Institute of Clinical Pathophysiology, HUN-REN-SE, Cerebrovascular and Neurocognitive Disease Research Group, Semmelweis University, Budapest, Hungary
2. Research Center for Sport Physiology, Hungarian University of Sports Science, Budapest, Hungary
3. Department of Cell and Molecular Physiology, New York Medical College, Valhalla, NY, USA
Interests: regulation of cerebral blood flow in heath and diseased conditions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The endothelium plays a pivotal role in the maintenance of various vascular functions, such as vascular reactivity to stimuli, coagulation, inflammatory responses, etc. Endothelial dysfunction underlies all cardiometabolic diseases (e.g., hypertension, diabetes mellitus, autoimmune diseases, coronary heart disease). Although exercise has a beneficial impact on endothelial function and prevents cardiovascular diseases or alleviates them, strenuous exercise can also lead to endothelial dysfunction and vascular/tissue damage. It is well documented that increased oxidative stress has a deleterious effect on endothelium-dependent vascular function by altering the different metabolic pathways involved in vascular reactivity. On the other hand, different nutraceuticals with antioxidative and anti-inflammatory properties can significantly impact vascular function and cardiovascular health. For professional athletes, appropriate nutrition is necessary to perform a lot of physical and metabolic activity to match their increased energy and nutritional needs. Nutritional supplements, such as nutrients with antioxidative properties, may play a role in preparing for exercise, increasing the efficiency of exercise, supporting recovery from exercise, and helping to prevent injury. This may help to reduce exercise-induced inflammation. However, our understanding of the physiological mechanisms at the cellular and molecular level of the effects of various nutritional supplements on cardiovascular help is still insufficient. In addition, perivascular adipose tissue could also be affected by nutrition, and the modulation of neural and hormonal systems could also be important. Some of the possible underlying mechanisms include the modification of oxidative stress via different pathways, such as the NRF2-transcription factor pathway, which influences vascular function. There is a need for controlled randomized studies on the effects of nutrients in athletes, as well as in sedentary people, on cardiovascular health in terms of preventive and potentially curative effects. There is a high degree of uncertainty surrounding the doses, duration, and chronic effects of nutritional supplementation (in food or in the form of pharmaceutical remedies). Moderate physical activity independently provides beneficial effects for cardiovascular health. Thus, in this Special Issue, review and original research articles performed on humans or experimental models regarding the effects of nutritional supplements, enriched food, or physical activity independently or in the interaction with nutrition on the cardiovascular health of athletes and sedentary persons are welcome to be submitted.

Given that the first edition of this Special Issue was a great success, we now invite you to publish in the second edition (https://www.mdpi.com/journal/life/special_issues/25G5Q0C6F9).

Prof. Dr. Ines Drenjančević
Prof. Dr. Akos Koller
Guest Editors

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Keywords

  • athletes
  • sedentary
  • eating habits
  • nutrition
  • endothelium
  • microcirculation
  • nutritional supplements
  • oxidative stress
  • antioxidants
  • NRF2-signalling pathway
  • functional food
  • cardiovascular function
  • prevention
  • physical activity

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