Personalized Medicine for Maternal–Fetal Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 25 March 2027 | Viewed by 984

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Guest Editor
Unit of Gynecology and Obstetric, Department of Biomedical and Dental Sciences and Morpho Functional Imaging, University Hospital “G. Martino” of Messina, 98100 Messina, Italy
Interests: pregnancy-related diseases; endometrial; endometriosis; laparoscopic; preterm birth; cholestasis in pregnancy; gynecology and obstetric
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Special Issue Information

Dear Colleagues,

Personalized medicine is transforming maternal–fetal care, evolving from traditional one-size-fits-all approaches to targeted therapies that consider individual genetic, environmental, and lifestyle factors. This paradigm shift is particularly crucial in obstetrics, where early detection and customized interventions can significantly improve outcomes for both mother and child. This Special Issue will explore advances in managing diseases in pregnancy, including endometriosis, preterm birth, preeclampsia, gestational diabetes, and other complex conditions. We aim to highlight cutting-edge research on biomarkers, genomics, epigenetics, and minimally invasive techniques such as cell-free fetal DNA analysis and advanced imaging technologies.

We invite original studies and comprehensive reviews that focus on tailored diagnostics, precision therapeutic strategies, and the evaluation of long-term outcomes in obstetrics and gynecology. This collection will serve as a valuable resource for clinicians, researchers, and policymakers dedicated to advancing women’s health through personalized approaches.

Dr. Roberta Granese
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy complication
  • endometriosis in pregnancy
  • premature birth
  • genomics
  • personalized medicine

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Published Papers (1 paper)

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Review

17 pages, 3740 KB  
Review
Models of Perinatal Palliative Care for Pregnant Women and Their Fetuses with Life-Limiting Conditions: A Literature Review
by Daniela Valle Almeida Figueredo, Silvia de Lourdes Loreto Faquini, Edward Araujo Júnior, Tammy Caram Sabatine, Gustavo Yano Callado, Antonio Braga, Roberta Granese and Alex Sandro Rolland Souza
J. Pers. Med. 2026, 16(7), 353; https://doi.org/10.3390/jpm16070353 - 30 Jun 2026
Viewed by 561
Abstract
Objective: To review the literature on palliative care protocols and models of care for pregnant women and their fetuses with life-limiting conditions. Methods: A narrative literature review was conducted in the PubMed/MEDLINE and Virtual Health Library (VHL)—BIREME/SciELO/LILACS, using the descriptors “palliative [...] Read more.
Objective: To review the literature on palliative care protocols and models of care for pregnant women and their fetuses with life-limiting conditions. Methods: A narrative literature review was conducted in the PubMed/MEDLINE and Virtual Health Library (VHL)—BIREME/SciELO/LILACS, using the descriptors “palliative care” and “prenatal care”. Studies of all designs published between February 2015 and May 2025 were considered for inclusion. Articles in languages other than Portuguese, English, and Spanish, duplicates, and those that did not discuss care protocols or experiences in perinatal palliative care for life-limiting fetal conditions starting from prenatal care were excluded. Articles were selected through title, abstract, and full-text screening. Results: Twenty-one studies focused on prenatal care were selected, presenting protocols and experiences of care in palliative fetal medicine. Most addressed the diagnosis of life-limiting fetal malformations, prenatal care, birth and delivery plan, perinatal grief and the puerperium. Across the included studies, a recurring emphasis on individualized, patient and family-centered approaches was identified, reflecting core principles of personalized medicine. Tailoring communication, care planning, and bereavement support to the specific clinical, genetic, cultural, and psychosocial profile of each dyad emerged as a structural characteristic of effective perinatal palliative care models. Conclusions: There is a scarcity of specific palliative care protocols for pregnancy, indicating a need to expand studies. The reviewed literature can contribute to the creation and adaptation of palliative care protocols and models for pregnant women and their fetuses with life-limiting conditions, may support more consistent care planning, improved communication, and better alignment with parental values. Full article
(This article belongs to the Special Issue Personalized Medicine for Maternal–Fetal Medicine)
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