Bioactive Secondary Metabolites from Fungi

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1013

Special Issue Editor


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Guest Editor
1. Department Microbial Drugs, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
2. Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt
Interests: natural product chemistry; structure elucidation; NMR spectroscopy; neurodegenerative disorders; biofilm inhibition; antimicrobial
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Special Issue Information

Dear Colleagues,

Fungi are ubiquitous eukaryotic organisms that can accommodate a vast variety of ecosystems. They vary from being safe edible foods to medicinal mushrooms or sometimes highly toxic variants. From the latest count of the number of fungi on the planet, it was estimated that there are 1.5 million species, with only one-tenth of these explored so far. Therefore, fungal diversity is still a promising research topic. In this Special Issue, we aim to valorize fungal secondary metabolites with interesting bioactivity/bioactivities in terms of their antimicrobial, antiproliferative, anti-inflammatory, antioxidant, and antidiabetic properties, related neurodegenerative disorders, and others.

You are welcome to contribute to this Special Issue by submitting your research and/or review articles related to the topic of “Bioactive Secondary Metabolites from Fungi”. We look forward to receiving your valuable contributions.

Prof. Dr. Sherif S. Ebada
Guest Editor

Manuscript Submission Information

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Keywords

  • fungal biodiversity
  • natural products
  • anti-infective
  • antibiotic resistance
  • biofilm inhibition
  • neurodegenerative disorders

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Published Papers (2 papers)

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Review

31 pages, 2867 KiB  
Review
A Comprehensive Review on Chemical Structures and Bioactivities of Ostropomycetidae Lichens
by Yunhui Wang, Chengyue Hao, Shuhao Jiang, Yanhu Ju, Wei Li and Zefeng Jia
J. Fungi 2025, 11(5), 369; https://doi.org/10.3390/jof11050369 - 9 May 2025
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Abstract
Lichenized fungi, recognized as an ecologically vital and pharmaceutically promising resource, hold substantial value in both environmental conservation and medicinal applications. As the second largest subclass within the lichen-forming fungi of Lecanoromycetes, Ostropomycetidae emerged as a critical reservoir of bioactive secondary metabolites. Current [...] Read more.
Lichenized fungi, recognized as an ecologically vital and pharmaceutically promising resource, hold substantial value in both environmental conservation and medicinal applications. As the second largest subclass within the lichen-forming fungi of Lecanoromycetes, Ostropomycetidae emerged as a critical reservoir of bioactive secondary metabolites. Current research has revealed that these secondary metabolites demonstrate remarkable bioactivities, positioning them as potential sources for novel pharmaceutical compounds. Despite considerable progress in characterizing chemical constituents and evaluating bioactivities within this subclass, a systematic summary of these discoveries remains absent. This review synthesizes the lichenochemical research progress, providing critical evaluations of 202 structurally characterized compounds from Ostropomycetidae lichen species over recent decades. These Ostropomycetidae-derived compounds cover the phenols, polyketides, fatty acids, terpenoids, steroids, and non-ribosomal peptides, and exhibit diverse bioactivities including antitumor, anti-inflammatory, antibacterial, antifungal, antiviral, antioxidant, anti-angiogenic, anti-neurodegenerative diseases, antitubercular, anti-herbivore, and antitrypanosomal, and so on. The aim of this review is to establish a robust chemodiversity framework and to offer strategic guidance for targeted exploration of lichen-derived drug candidates in the biological resources of Ostropomycetidae lichens. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites from Fungi)
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46 pages, 3153 KiB  
Review
Unveiling the Bioactive Compounds and Therapeutic Potential of Russula: A Comprehensive Review
by Jingya Yang, Samantha C. Karunarathna, Nimesha Patabendige, Entaj Tarafder, Dengji Lou, Yuanqing Zhou and Kalani Hapuarachchi
J. Fungi 2025, 11(5), 341; https://doi.org/10.3390/jof11050341 - 27 Apr 2025
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Abstract
Russula, a genus of Basidiomycetes with considerable taxonomic diversity, holds significant potential in both traditional and modern medicinal practices. This comprehensive review explores the bioactive compounds identified in various Russula species, detailing their characterization, structural elucidation, and classification. The medicinal properties of [...] Read more.
Russula, a genus of Basidiomycetes with considerable taxonomic diversity, holds significant potential in both traditional and modern medicinal practices. This comprehensive review explores the bioactive compounds identified in various Russula species, detailing their characterization, structural elucidation, and classification. The medicinal properties of these fungi are examined, with a focus on their antioxidant, anti-inflammatory, and immunomodulatory effects, supported by both historical usage and contemporary preclinical pharmacological research. The review also highlights emerging biotechnological applications including environmental remediation, antimicrobial agents, and functional food development. Safety and toxicological considerations are evaluated to provide a balanced perspective on the medicinal use of Russula. The review concludes by summarizing the key findings and emphasizing the importance of Russula in both traditional medicine and future clinically validated innovations. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites from Fungi)
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