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Fungal Wonders: Investigating the Diverse Biological Activities of Fungal-Derived Compounds
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Fungal Wonders: Investigating the Diverse Biological Activities of Fungal-Derived Compounds

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1338

Special Issue Editors

Dr. Milena Rašeta

E-Mail Website
Guest Editor
Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia
Interests: biochemistry; mycology; fungi; medicinal mushrooms; biological properties; phenolics; polyamines; primary metabolites; secondary metabolites
Prof. Dr. Maja Karaman

E-Mail Website
Guest Editor
Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Serbia
Interests: microbiology; mycology; biodiversity; environment; biochemistry; biotechnology; bioactive compounds of medicinal mushrooms; lignicolous macrofungi; bioactivity of fungal metabolites; fungal based biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, "Biological Activity of Fungal Extracts", delves into the remarkable diversity of biologically active compounds derived from fungi, including proteins, polysaccharides, polyphenolics, and more. Through a multidisciplinary approach, this Special Issue aims to showcase the latest research on fungal-derived compounds through a multidisciplinary lens, thereby emphasizing their roles in medicine, particularly as nutraceuticals and pharmaceuticals. This collection of articles provides insights into the rich diversity and untapped potential of fungal bioactive compounds, paving the way for future discoveries and applications in various fields.

Scientists are encouraged to explore the potential medicinal applications of these compounds, such as their antioxidant, antidiabetic, and antilipolytic properties, as well as others. Moreover, we seek to publish papers that uncover the applications of these compounds in edible, non-edible, and traditionally used fungal species, whether in the form of teas, extracts, food supplements, or as direct food sources, with a particular focus on edible fungi. We aim to unravel the inherent wonders of fungi and shed light on their significant contributions to human health and well-being. The overarching topic, "Fungal Wonders: Investigating the Diverse Biological Activities of Fungal-Derived Compounds", underscores the multifaceted nature of fungal bioactive compounds and their potential impact on various aspects of life and healthcare. The focus is on examining these effects to reveal the possible therapeutic and ecological importance of fungal extracts.

Dr. Milena Rašeta
Prof. Dr. Maja Karaman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal extracts
  • edible fungi
  • mushrooms
  • biological activity
  • medicinal applications
  • antioxidant properties
  • antidiabetic effects
  • polyphenolics
  • multidisciplinary research
  • traditional medicine

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Published Papers (1 paper)

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Research

19 pages, 2408 KiB  
Article
Ganoderma pfeifferi Bres. and Ganoderma resinaceum Boud. as Potential Therapeutic Agents: A Comparative Study on Antiproliferative and Lipid-Lowering Properties
by Milena Rašeta, Marko Kebert, Jovana Mišković, Saša Kostić, Sonja Kaišarević, Nebojša Stilinović, Saša Vukmirović and Maja Karaman
J. Fungi 2024, 10(7), 501; https://doi.org/10.3390/jof10070501 - 19 Jul 2024
Viewed by 577
Abstract
Medicinal mushrooms, especially Ganoderma species, hold immense promise for the production of a wide range of bioactive compounds with various effects. The biochemical potential of indigenous fungal strains, specific to a region, could play a critical role in the continuous search for novel [...] Read more.
Medicinal mushrooms, especially Ganoderma species, hold immense promise for the production of a wide range of bioactive compounds with various effects. The biochemical potential of indigenous fungal strains, specific to a region, could play a critical role in the continuous search for novel strains with superior activities on a global scale. This research focused on the ethanolic (EtOH) and hot-water (H2O) extracts of fruiting bodies of two wild-growing Ganoderma species: G. pfeifferi and G. resinaceum, with the aim of assessing their nutritional (total carbohydrate content-TCC) and mineral composition in relation to bioactive properties: antioxidant, antiproliferative and lipid-lowering. Atomic absorption spectrophotometry (AAS) revealed that G. pfeifferi is a promising source of minerals that are essential for numerous physiological functions in the human body like bone health and muscle and nerve function, with Ca (4.55 ± 0.41 mg/g d.w.) and Mg (1.33 ± 0.09 mg/g d.w.) being the most abundant macroelement present. Zn, Mn, and Cr were particularly notable, with concentrations ranging from 21.49 to 41.70 mg/kg d.w. The EtOH extract of G. pfeifferi demonstrated significantly elevated levels of TCC, essential macromolecules for energy and structural functions in the body, with higher quantities of all three standard carbohydrates detected in this type of extract. Similar to the revealed composition, the same species, G. pfeifferi, stood out as the most prominent antioxidant agent, with the H2O extract being stronger than EtOH in the ABTS assay (86.85 ± 0.67 mg TE/g d.w.), while the EtOH extract displayed the highest anti-OH• scavenging ability (IC50 = 0.18 ± 0.05 μg/mL) as well as the most notable reducing potential among all. The highest antiproliferative effect against the breast cancer cell line (MCF-7), were demonstrated by the H2O extracts from G. resinaceum with the most pronounced activity after 24 h (IC50 = 4.88 ± 0.50 μg/mL), which surpasses that of the standard compound, ellagic acid (IC50 = 33.94 ± 3.69 μg/mL). Administration of both Ganoderma extracts mitigated diabetic lipid disturbances and exhibited potential renal and hepatic protection in vivo on white Wistar rats by the preservation of kidney function parameters in G. resinaceum H2O pre-treatment (urea: 6.27 ± 0.64 mmol/L, creatinine: 50.00 ± 6.45 mmol/L) and the reduction in ALT levels (17.83 ± 3.25 U/L) compared to diabetic control groups treated with saline (urea: 46.98 ± 6.01 mmol/L, creatinine: 289.25 ± 73.87 mmol/L, and ALT: 60.17 ± 9.64 U/L). These results suggest that pre-treatment with G. resinaceum H2O extracts may have potential antidiabetic properties. In summary, detected microelements are vital for maintaining overall health, supporting metabolic processes, and protecting against various chronic diseases. Further research and dietary assessments could help determine the full potential and applications of the two underexplored Ganoderma species native to Serbia in nutrition and health supplements. Full article
(This article belongs to the Special Issue Fungal Wonders: Investigating the Diverse Biological Activities of Fungal-Derived Compounds)
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