Fusarium spp.: A Trans-Kingdom Fungus, 2nd Edition

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1831

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Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057, USA
Interests: pathogenesis of human yeast infections; molecular pathogenesis; antifungals; drug resistance; bioinformatics; mitochondria
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Special Issue Information

Dear Colleagues,

A number of environmental and pathogenic fungi are collectively referred to as trans-kingdom pathogenic fungi, meaning that they cause both human and plant (crop) diseases. The loss of crop production due to organisms such as Fusarium threatens food security. These environmental organisms are unlikely to fall into the category of other fungal pathogens such as the Candida species Cryptococcus neoformans, or endemic fungi, such as Histoplasma capsulatum, causing significant human but not crop diseases. The Fusarium and Aspergillus species rank among the most important of the trans-kingdom pathogens. Throughout the past decade, interesting studies have described molecular pathogenesis, azole resistance, and soil and plant microbiomes as sources of potential new antifungals and the relationships with human disease, especially regarding patients with life-threatening underlying conditions. Current data describe the azole resistance of environmental isolates of both fungal groups. These data pose the possibility of the air-borne transfer of azole-resistant isolates from the environment to patients, since azoles are used to protect crops from fungal diseases.

For this Special Issue, we will accept both original research articles and review papers focused on all studies of fusarium, either on humans or associated with soil or plants.

Prof. Dr. Richard Calderone
Guest Editor

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Keywords

  • biology
  • host interactions
  • the microbiome
  • virulence
  • molecular pathogenicity
  • clinical observations
  • azole resistance

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Published Papers (2 papers)

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Research

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19 pages, 6108 KiB  
Article
Fusarium musae Infection in Animal and Plant Hosts Confirms Its Cross-Kingdom Pathogenicity
by Valeria Tava, Agustin Reséndiz-Sharpe, Eliane Vanhoffelen, Marco Saracchi, Paolo Cortesi, Katrien Lagrou, Greetje Vande Velde and Matias Pasquali
J. Fungi 2025, 11(2), 90; https://doi.org/10.3390/jof11020090 - 24 Jan 2025
Viewed by 767
Abstract
Fusarium musae is a pathogen belonging to the Fusarium fujikuroi species complex, isolated from both banana fruits and immunocompromised patients, therefore hypothesized to be a cross-kingdom pathogen. We aimed to characterize F. musae infection in plant and animal hosts to prove its cross-kingdom [...] Read more.
Fusarium musae is a pathogen belonging to the Fusarium fujikuroi species complex, isolated from both banana fruits and immunocompromised patients, therefore hypothesized to be a cross-kingdom pathogen. We aimed to characterize F. musae infection in plant and animal hosts to prove its cross-kingdom pathogenicity. Therefore, we developed two infection models, one in banana and one in Galleria mellonella larvae, as a human proxy for the investigation of cross-kingdom pathogenicity of F. musae, along with accurate disease indexes effective to differentiate infection degrees in animal and plant hosts. We tested a worldwide collection of F. musae strains isolated both from banana fruits and human patients, and we provided the first experimental proof of the ability of all strains of F. musae to cause significant disease in banana fruits, as well as in G. mellonella. Thereby, we confirmed that F. musae can be considered a cross-kingdom pathogen. We, thus, provide a solid basis and toolbox for the investigation of the host–pathogen interactions of F. musae with its hosts. Full article
(This article belongs to the Special Issue Fusarium spp.: A Trans-Kingdom Fungus, 2nd Edition)
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Review

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16 pages, 910 KiB  
Review
The Dual Pathogen Fusarium: Diseases, Incidence, Azole Resistance, and Biofilms
by Dongmei Li, Kincer Amburgey-Crovetti, Emilie Applebach, Tomoko Y. Steen and Richard Calderone
J. Fungi 2025, 11(4), 294; https://doi.org/10.3390/jof11040294 - 9 Apr 2025
Viewed by 777
Abstract
The increasing resistance of Fusarium species to nearly all first-line antifungal agents in clinical settings has led to its designation as a ‘high-priority’ human pathogen. As a dual pathogen, Fusarium spp. threaten both human health and crop production, impacting food security. Our recent [...] Read more.
The increasing resistance of Fusarium species to nearly all first-line antifungal agents in clinical settings has led to its designation as a ‘high-priority’ human pathogen. As a dual pathogen, Fusarium spp. threaten both human health and crop production, impacting food security. Our recent drug profiling of clinical Fusarium isolates reveals resistance to several front-line antifungals, with notable cross-azole resistance observed in both clinical and plant-associated strains. While the overuse of agricultural azoles has been implicated in the selection of azole-resistant fungi such as Aspergillus, a similar mechanism has been assumed for Fusarium in clinical settings. However, direct genetic evidence supporting this hypothesis remains limited. In this review, part of our Special Interest (SI) series, we discuss the spectrum of human diseases caused by Fusarium. While incidence data are better established for human keratitis and onychomycosis, invasive fusariosis remains globally underreported. We propose reasons for this distinct clinical spectrum bias and explore the potential genetic basis of azole resistance. Full article
(This article belongs to the Special Issue Fusarium spp.: A Trans-Kingdom Fungus, 2nd Edition)
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