Personalized Mycology

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2598

Special Issue Editor


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Guest Editor
Professor of Microbiology and Medical Mycology, Medical Mycology Reference Laboratory, Institute of Microbiology and Immunology, University of Belgrade Faculty of Medicine, Belgrade, Serbia
Interests: laboratory diagnosis of fungal infections; local and global fungal epidemiology and resistance; modeling of laboratory process; innovative approach in personalized medical mycology
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Special Issue Information

Dear Colleagues,

Almost a quarter of the world’s population has a chronic or long-lasting fungal infection (FI) or disease. An unsuspected, undetected and untreated FI in several medical settings may lead to a fatal outcome, so personalized approaches with timely patient screening and diagnostics are important. Additionally, a precise, simple, acceptable and user-friendly oriented concept with accurate laboratory diagnosis may provide better patient support. Since the fungal pathogenicity is complex, and some fungi have the capacity to form a biofilm which is crucial for establishing a chronic form of disease or failure of therapy, fungal positive or negative findings and differentiation between mycobiome, infection or disease complication is challenging. In this respect, the comprehensive comparative laboratory analyses and patient risk scoring could improve personalized mycology and disease control, as well as early prediction and accuracy of laboratory diagnosis, performed both with culture- or non-culture-based approaches.

Personalized mycology with prediction, prevention, personalization and patient’s participation evolving the landscape of fungal diagnostics is a state-of-the-art approach and a key pillar of the 21st century challenges in medical mycology. Therefore, we invite all medical doctors and scientists to submit papers with studies which support  this new research and health service model in clinical mycology.

Best wishes,
Prof. Dr. Valentina Arsic Arsenijevic
Guest Editor

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Keywords

  • skin and nail fungal infection
  • mucosal fungal infection
  • fungal sinusitis
  • personalized diagnosis
  • questioner for risks calculation
  • disease screening and control innovative tools

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Published Papers (1 paper)

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Research

13 pages, 2888 KiB  
Article
Epidemiology of Onychomycosis in the United States Characterized Using Molecular Methods, 2015–2024
by Aditya K. Gupta, Tong Wang, Shruthi Polla Ravi, Avantika Mann, Sara A. Lincoln, Hui-Chen Foreman and Wayne L. Bakotic
J. Fungi 2024, 10(9), 633; https://doi.org/10.3390/jof10090633 - 5 Sep 2024
Viewed by 1374
Abstract
Onychomycosis is a recalcitrant fungal infection of the nail unit that can lead to secondary infections and foot complications. Accurate pathogen identification by confirmatory testing is recommended to improve treatment outcomes. In this study, we reviewed the records of 710,541 patients whose nail [...] Read more.
Onychomycosis is a recalcitrant fungal infection of the nail unit that can lead to secondary infections and foot complications. Accurate pathogen identification by confirmatory testing is recommended to improve treatment outcomes. In this study, we reviewed the records of 710,541 patients whose nail specimens were sent to a single molecular diagnostic laboratory between 2015 and 2024. PCR testing revealed a more comprehensive spectrum of pathogens than previously reported, which was corroborated by the demonstration of fungal invasion on histopathology. Consistent with our current understanding, the T. rubrum complex (54.3%) are among the most common pathogens; however, a significant portion of mycology-confirmed diagnoses were caused by the T. mentagrophytes complex (6.5%), Aspergillus (7.0%) and Fusarium (4.5%). Females were significantly more likely to be infected with non-dermatophytes molds (NDMs; OR: 2.0), including Aspergillus (OR: 3.3) and Fusarium (OR: 2.0), and yeasts (OR: 1.5), including Candida albicans (OR: 2.0) and C. parapsilosis (OR 1.6), than males. The T. mentagrophytes complex became more prevalent with age, and conversely the T. rubrum complex became less prevalent with age. Patients aged ≥65 years also demonstrated a higher likelihood of contracting onychomycosis caused by NDMs (OR: 1.6), including Aspergillus (OR: 2.2), Acremonium (OR: 3.5), Scopulariopsis (OR: 2.9), Neoscytalidium (OR: 3.8), and yeasts (OR: 1.8), including C. albicans (OR: 1.9) and C. parapsilosis (OR: 1.7), than young adults. NDMs (e.g., Aspergillus and Fusarium) and yeasts were, overall, more likely to cause superficial onychomycosis and less likely to cause dystrophic onychomycosis than dermatophytes. With regards to subungual onychomycosis, Aspergillus, Scopulariopsis and Neoscytalidium had a similar likelihood as dermatophytes. The advent of molecular diagnostics enabling a timely and accurate pathogen identification can better inform healthcare providers of appropriate treatment selections and develop evidence-based recommendations. Full article
(This article belongs to the Special Issue Personalized Mycology)
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