Advances in Machine Learning for Medical Imaging Applications

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue, which aims to showcase the latest advancements in machine learning for medical imaging. The rapid progress of artificial intelligence (AI) has revolutionized medical imaging by enhancing disease detection, segmentation, and image reconstruction. Machine learning techniques, particularly deep learning and generative models, have significantly improved the accuracy and efficiency of diagnostic imaging. These advancements are critical in clinical applications, including early disease detection, personalized treatment planning, and automated workflow optimization. However, challenges such as data scarcity, model interpretability, and generalization across diverse patient populations remain active areas of research. This Special Issue aims to explore cutting-edge machine learning methodologies and their applications in medical imaging. By bringing together state-of-the-art research, we seek to advance the field and provide a deeper understanding of AI-driven medical diagnostics. The scope includes, but is not limited to, the following:

• Novel AI architectures for medical image analysis;
• Comparative evaluations of deep learning models in real-world medical imaging scenarios;
• The integration of machine learning with existing imaging workflows;
• Strategies for improving robustness, generalization, and explainability in AI-based healthcare solutions.

This Special Issue aligns with the journal’s scope by emphasizing the interdisciplinary nature of medical imaging, combining expertise from AI, computer vision, and medical sciences to drive impactful innovations.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

• Generative Models for Medical Imaging: Utilization of GANs and diffusion models for MRI/CT image synthesis and enhancement.
• Automated Disease Detection and Segmentation: Development and comparison of SotA deep learning architectures for detecting diseases in medical scans.
• Post-Processing and Ground Truth Refinement: AI-driven techniques to enhance segmentation accuracy for cancer and pathological region detection.
• Brain Imaging and Neurological Disorders: Machine learning applications for autism spectrum disorder (ASD) detection, stroke analysis, and neurodegenerative disease diagnosis.
• Multimodal Learning in Medical Imaging: Fusing MRI, CT, PET, and ultrasound data for improved diagnostic accuracy.
• Few-Shot and Self-Supervised Learning: Overcoming data scarcity issues with novel training paradigms.
• AI Explainability and Trustworthiness in Healthcare: Enhancing model interpretability and regulatory compliance in medical imaging AI.

Dr. Eftychios E. Protopapadakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Imaging is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• medical imaging
• deep learning
• GANs
• MRI reconstruction
• segmentation
• disease detection
• multimodal learning
• explainability
• AI in healthcare