Special Issue "Materials and Technology for Regenerative Medicine"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Dr. Ewa Stodolak-Zych
E-Mail Website
Guest Editor
Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, 30-059 Krakow, Poland
Interests: porous and nonporous materials supported regenerative process: polymer nanocomposites; fibrous materials; polymer membrane; cells–materials interaction
Dr. Maciej Boguń
E-Mail Website
Guest Editor
Łukasiewicz Research Network - Textile Research Institute, 92-103 Łódź, Poland
Interests: woven and unwoven materials; electrospinning; melt blown techniques; biomaterials; standard tests; biomedical application

Special Issue Information

Dear Colleagues,

The idea of regenerative medicine requires the conscious use of biological, medical, and material techniques aimed at repairing and restoring normal function of damaged cells or organs, preferably at the site of destruction (in situ). Currently used regenerative medicine strategies are mainly based on induced autoregeneration, somatic cell therapy, and tissue engineering (TE). Wherever there is a need to restore large defects (i.e., critical defects) or to introduce an induced response from the body (induced autoregeneration), biomaterials are used.

Biomaterials applied in the context of regenerative medicine play the role of an active agent in the regenerative process, which is intended to facilitate, imitate, and/or reinforce the biological processes involved. The essential role of biomaterial during the regeneration of the damage may be limited to a synthetic imitation of an extracellular matrix (ECM). This approach has provided an insight into the role and function of progenitor cells and stem cells. Biomimetic materials inspired by nature are intended to reproduce the natural tissue environment on both structural and functional levels. The success of self-regenerative strategies depends equally on the predictability of the material's in vivo behavior. The substrate is expected to perform its function in a predetermined way and then degrade (not only in uncontrolled hydrolysis), e.g., in response to local changes and regeneration or colonization with native ECM cells.

Successful treatment supported with the use of biomaterials cannot exist without technologies that facilitate the forming of biomimetic supports, which stimulate regenerative processes. Most of the techniques used for regenerative medicine are traditional ones, e.g., used in the textile industry, polymer processing or ceramics technology. Among them, there are new methods allowing to obtain nanocomposites or those with highly specialized surface properties which favor adhesion or proliferation of a specific group of cells (important for the damaged site). These techniques allow obtaining substrates in the form of both 2D and 3D structures. This increases the chances of clinical application of biomaterials, although these will only be possible if not only the characteristics of the material and its safety (including the sterilization technique) are known, but also repeatability is ensured using the suitable technology.

Dr. Ewa Stodolak-Zych
Dr. Maciej Boguń
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetic materials
  • scaffold
  • 2D and 3D biomaterials
  • bioactivity
  • (nano)composite materials
  • fibrous materials
  • porous materials
  • polymer processing
  • ceramic technology
  • cells-materials interaction
  • (bio)degradation
  • regenerative process

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Open AccessArticle
Establishment of Collagen: Hydroxyapatite/BMP-2 Mimetic Peptide Composites
Materials 2020, 13(5), 1203; https://doi.org/10.3390/ma13051203 - 07 Mar 2020
Abstract
Extensive efforts were undertaken to develop suitable biomaterials for tissue engineering (TE) applications. To facilitate clinical approval processes and ensure the success of TE applications, bioinspired concepts are currently focused on. Working on bone tissue engineering, we describe in the present study a [...] Read more.
Extensive efforts were undertaken to develop suitable biomaterials for tissue engineering (TE) applications. To facilitate clinical approval processes and ensure the success of TE applications, bioinspired concepts are currently focused on. Working on bone tissue engineering, we describe in the present study a method for biofunctionalization of collagen/hydroxyapatite composites with BMP-2 mimetic peptides. This approach is expected to be fundamentally transferable to other tissue engineering fields. A modified BMP-2 mimetic peptide containing a negatively charged poly-glutamic acid residue (E7 BMP-2 peptide) was used to bind positively charged hydroxyapatite (HA) particles by electrostatic attraction. Binding efficiency was biochemically detected to be on average 85% compared to 30% of BMP-2 peptide without E7 residue. By quartz crystal microbalance (QCM) analysis, we could demonstrate the time-dependent dissociation of the BMP-2 mimetic peptides and the stable binding of the E7 BMP-2 peptides on HA-coated quartz crystals. As shown by immunofluorescence staining, alkaline phosphatase expression is similar to that detected in jaw periosteal cells (JPCs) stimulated with the whole BMP-2 protein. Mineralization potential of JPCs in the presence of BMP-2 mimetic peptides was also shown to be at least similar or significantly higher when low peptide concentrations were used, as compared to JPCs cultured in the presence of recombinant BMP-2 controls. In the following, collagen/hydroxyapatite composite materials were prepared. By proliferation analysis, we detected a decrease in cell viability with increasing HA ratios. Therefore, we chose a collagen/hydroxyapatite ratio of 1:2, similar to the natural composition of bone. The following inclusion of E7 BMP-2 peptides within the composite material resulted in significantly elevated long-term JPC proliferation under osteogenic conditions. We conclude that our advanced approach for fast and cost-effective scaffold preparation and biofunctionalization is suitable for improved and prolonged JPC proliferation. Further studies should prove the functionality of composite scaffolds in vivo. Full article
(This article belongs to the Special Issue Materials and Technology for Regenerative Medicine)
Show Figures

Figure 1

Back to TopTop