Antimicrobial Peptides for Therapeutic Applications

A special issue of Biologics (ISSN 2673-8449).

Deadline for manuscript submissions: closed (1 May 2023) | Viewed by 6223

Special Issue Editor


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Guest Editor
Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-033 Lublin, Poland
Interests: antimicrobial peptides; neutrophils; macrophages; biomaterials; regenerative medicine; immunomodulation; veterinary pathology; blood clotting disorders
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Special Issue Information

Dear Collegues,

It is my pleasure to announce a new Special Issue entitled “Antimicrobial Peptides for Therapeutic Applications”, for which I am serving as Guest Editor and to which I sincerely invite you to contribute your research work based on your expertise.

Antimicrobial peptides, also known as host defense peptides, are a promising group of naturally derived or synthetic products composed of short peptides with antimicrobial and immunomodulatory properties with potential for different clinical applications, e.g., regenerative medicine.

This Special Issue of Biologics will cover new research in the area of antimicrobial peptides as biologics. The focus of this issue will be on the interactions of antimicrobial peptides with host cells and the mechanism of their multiple biological functions, as well as the methods for their characterization. Additionally, research on clinical and pre-clinical experiments involved in the application of antimicrobial peptides in human medicine and on animal models is warmly welcome. We particularly welcome original research papers and reviews on the potential use or clinical application of antimicrobial peptides in biomedical sciences. Manuscripts are due on 31 December 2022, but earlier submissions are welcome, and they will be processed upon receipt and published online upon acceptance.

Dr. Joanna Wessely-Szponder
Guest Editor

Manuscript Submission Information

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Keywords

  • antimicrobial peptides
  • host defense peptides
  • cathelicidins
  • blood components
  • tissue repair
  • biologics
  • immunomodulators

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Published Papers (1 paper)

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Review

15 pages, 345 KiB  
Review
Therapeutic Role of Antimicrobial Peptides in Diabetes Mellitus
by Julia Depta, Paulina Małkowska, Monika Wysokińska, Karolina Todorska, Olga Sierawska, Rafał Hrynkiewicz, Dominika Bębnowska and Paulina Niedźwiedzka-Rystwej
Biologics 2022, 2(1), 92-106; https://doi.org/10.3390/biologics2010008 - 18 Mar 2022
Cited by 9 | Viewed by 5453
Abstract
Antimicrobial peptides (AMPs) have recently become widely publicized because they have the potential to function in alternative therapies as “natural” antibiotics, with their main advantage being a broad spectrum of activity. The potential for antimicrobial peptides to treat diabetes mellitus (DM) has been [...] Read more.
Antimicrobial peptides (AMPs) have recently become widely publicized because they have the potential to function in alternative therapies as “natural” antibiotics, with their main advantage being a broad spectrum of activity. The potential for antimicrobial peptides to treat diabetes mellitus (DM) has been reported. In diabetes mellitus type I (T1D), cathelicidin-related antimicrobial peptide (CRAMP), cathelicidin antimicrobial peptide (CAMP) and mouse-β- defensin 14 (mBD14) are positively affected. Decreased levels of LL-37 and human neutrophil peptide 1-3 (HNP1-3) have been reported in diabetes mellitus type II (T2D) relative to healthy patients. Moreover, AMPs from amphibians and social wasps have antidiabetic effects. In infections occurring in patients with tuberculosis-diabetes or diabetic foot, granulysin, HNP1, HNP2, HNP3, human beta-defensin 2 (HBD2), and cathelicidins are responsible for pathogen clearance. An interesting alternative is also the use of modified M13 bacteriophages containing encapsulated AMPs genes or phagemids. Full article
(This article belongs to the Special Issue Antimicrobial Peptides for Therapeutic Applications)
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