Special Issue "Diagnosis, Treatment and Outcome in Complicated Monochorionic Twins"
Deadline for manuscript submissions: closed (20 May 2019).
Twin gestations occur in 2% of all pregnancies. Two-thirds of these twin gestations are dizygotic and one-third are monozygotic, thus leading to identical twins. Dizygotic twin gestations are always dichorionic and have two separate placentas. In contrast, the majority of monozygotic twin gestations are monochorionic in which both twins share their placenta. Monochorionic twin placentas are characterized by the invariable presence of vascular anastomoses connecting the two fetal circulations. Unbalanced blood transfusion through the vascular anastomoses can lead to severe fetal complications such as twin-twin transfusion syndrome (TTS), twin anemia-polycythemia sequence (TAPS) of twin reversed arterial perfusion (TRAP). In case of unequal placental sharing, selective fetal growth restriction (sFGR) can occur. Accurate and timely detection of these potentially devastating complications is of utmost importance, as well as optimal antenatal and postnatal management. Management options include the use of minimally invasive surgical techniques such as fetoscopic laser coagulation of the vascular anastomoses or selective feticide using cord coagulation with bipolar forceps or radiofrequency ablation. Significant technological improvement in the field of fetal therapy has led to an increase in perinatal survival in the past decades. Nevertheless, the management of the various forms of complications in monochorionic twins remains a challenge in perinatal medicine. Surviving twins are at risk of developing severe cerebral injury and long-term neurodevelopment sequelae. Continuing close collaboration between fetal medicine specialists and neonatologists is crucial to improve the care and outcome of complicated monochorionic twins.
Prof. Dr. Enrico Lopriore
Prof. Dr. Asma Khalil
Prof. Dr. Liesbeth Lewi
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Monochorionic twins
- Twin-twin Transfusion Syndrome (TTS)
- Twin Anemia-Polycythemia Sequence (TAPS)
- Twin Reversed Arterial Perfusion (TRAP)
- Selective Fetal Growth Restriction (sFGR)
- Discordant anomaly
- Fetal therapy
- Clinical management
- Long-term neurodevelopment outcome