Addressing Alzheimer’s Disease: Blueprints and Therapeutic Hints

Dear Colleagues,

Alzheimer’s disease (AD), the most abundant form of dementia, currently represents a harsh social and economic issue worldwide. Rarely triggered by genetic mutations, AD is most commonly associated with a variety of risk factors, including aging, ApoE protein, cardiovascular diseases, diabetes and factors generally connected with increased inflammation levels (e.g., Western diet and sedentary lifestyle). Only a few symptomatic treatments are currently available; although several disease modifying agents are being tested in preclinical and clinical trials. Due to the heterogeneity of AD pathological hallmarks and clinical manifestations, research efforts are now being directed toward multitarget approaches and ad personam therapies. Only a precise and comprehensive understanding of the mechanisms triggering, developing and aggravating AD will guarantee an adequate response to the compelling need for effective treatments. This Special Issue of the Journal of Clinical Medicine will report on the current trends in AD prevention and curative strategies, highlighting new targets of intervention as well as novel therapeutic approaches.

Assist. Prof. Patrizia Giannoni
Dr. Sylvie Claeysen
Guest Editors

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