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Gynecologic and Obstetric Pathologies: From Birth to Menopause (Volume II)
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Gynecologic and Obstetric Pathologies: From Birth to Menopause (Volume II)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 2269

Special Issue Editor

Dr. Panagiotis Christopoulos

E-Mail Website
Guest Editor
2nd Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Interests: gynecology; obstetrics; reproductive; endocrinology; mullerian anomalies; PCOS; pediatric gynecology; high-risk pregnancy; adolescent gynecology; minimally invasive surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carrying on from the success of the Special Issue “Gynecologic and Obstetric Pathologies: From Birth to Menopause”, this second volume aims to continue publishing a broad range of original, peer-reviewed papers covering the full spectrum of obstetrics and gynecology.

The journal invites submissions on current high-quality research, reporting selected original experimental and clinical investigations in the fields of gynecology, obstetrics, and human reproduction. This Special Issue will address significant topics in gynecology and obstetrics through well-referenced review articles, meta-analyses, practice guidelines, and more. Case reports will also be considered if they have the potential to impact women's healthcare practices.

Topics of interest include general gynecology; reproductive medicine; and endocrinology, infertility, pediatric, and adolescent gynecology; menopause; urogynecology; gynecologic oncology; oncofertility; pelvic medicine; sexual medicine; minimally invasive gynecologic surgery; and the pros and cons of various techniques in gynecology and obstetrics; as well as high-risk pregnancy; prenatal diagnosis; maternal–fetal medicine; obstetrics; perinatology; and more. This Special Issue will focus particularly on the diagnosis, prediction, prevention, and treatment of obstetrical and gynecological disorders.

Given our global audience, the aim of the second volume of this Special Issue is to play a significant role in educating physicians worldwide. All published content will be accessible to everyone in an open access format.

Dr. Panagiotis Christopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstetrics
  • gynecology
  • pathology
  • pediatric and adolescent gynecology
  • menopause
  • urinary disorders
  • infertility
  • gynecologic oncology
  • maternal–fetal medicine
  • incontinence
  • menstruation
  • reproduction
  • polycystic ovarian syndrome
  • endometriosis
  • dysmenorrhea

Related Special Issue

Published Papers (3 papers)

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Research

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13 pages, 648 KiB  
Article
An Evaluation of DNA Methylation Levels and Sleep in Relation to Hot Flashes: A Cross-Sectional Study
by Ipek Betul Ozcivit Erkan, Hasan Hakan Seyisoglu, Gulcin Benbir Senel, Derya Karadeniz, Filiz Ozdemir, Aysel Kalayci, Mehmet Seven and Neslihan Gokmen Inan
J. Clin. Med. 2024, 13(12), 3502; https://doi.org/10.3390/jcm13123502 - 15 Jun 2024
Viewed by 604
Abstract
Objectives: We aimed to evaluate the DNA methylation levels in perimenopausal and postmenopausal women, measured through Long Interspersed Element-1 (LINE-1) and Alu, and the sleep parameters in relation to the presence of hot flashes (HFs). Methods: This cross-sectional study included 30 peri- or [...] Read more.
Objectives: We aimed to evaluate the DNA methylation levels in perimenopausal and postmenopausal women, measured through Long Interspersed Element-1 (LINE-1) and Alu, and the sleep parameters in relation to the presence of hot flashes (HFs). Methods: This cross-sectional study included 30 peri- or postmenopausal women aged between 45 and 55. The menopausal status was determined according to STRAW + 10 criteria and all participants had a low cardiovascular disease (CVD) risk profile determined by Framingham risk score. The sample was divided into two groups based on the presence or absence of HFs documented in their medical history during their initial visit: Group 1 (n = 15) with HFs present and Group 2 (n = 15) with HFs absent. The patients had polysomnography test and HFs were recorded both by sternal skin conductance and self-report overnight. Genomic DNA was extracted from the women’s blood and methylation status was analyzed by fluorescence-based real-time quantitative PCR. The quantified value of DNA methylation of a target gene was normalized by β-actin. The primary outcome was the variation in methylation levels of LINE-1 and Alu and sleep parameters according to the presence of HFs. Results: LINE-1 and Alu methylation levels were higher in Group 1 (HFs present), although statistically non-significant. LINE-1 methylation levels were negatively correlated with age. Sleep efficiency was statistically significantly lower for women in Group 1 (HFs present) (74.66% ± 11.16% vs. 82.63% ± 7.31%; p = 0.03). The ratio of duration of awakening to total sleep time was statistically significantly higher in Group 1 (HFs present) (22.38% ± 9.99% vs. 15.07% ± 6.93, p = 0.03). Objectively recorded hot flashes were significantly higher in Group 1 (4.00 ± 3.21 vs. 1.47 ± 1.46, p = 0.03). None of the cases in Group 2 self-reported HF despite objectively recorded HFs during the polysomnography. The rate of hot flash associated with awakening was 41.4% in the whole sample. Conclusions: Women with a history of hot flashes exhibited lower sleep efficiency and higher awakening rates. Although a history of experiencing hot flashes was associated with higher LINE-1 and Alu methylation levels, no statistical significance was found. Further studies are needed to clarify this association. This study was funded by the Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa. Project number: TTU-2021-35629. Full article
(This article belongs to the Special Issue Gynecologic and Obstetric Pathologies: From Birth to Menopause (Volume II))
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Review

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16 pages, 342 KiB  
Review
Visceral Leishmaniasis in a Twin Pregnancy: A Case Report and Review of the Literature
by Grigorios Karampas, Sevasti Koulouraki, George L. Daikos, Christina Nanou, Leon Aravantinos, Makarios Eleftheriades, Dimitra Metallinou and Panagiotis Christopoulos
J. Clin. Med. 2024, 13(8), 2400; https://doi.org/10.3390/jcm13082400 - 20 Apr 2024
Viewed by 870
Abstract
Visceral leishmaniasis (VL), often referred to as kala-azar, is quite rare in developed countries during pregnancy. Only few studies have evaluated its impact on perinatal outcome. It is caused primarily by Leishmania donovani or Leishmania infantum and presents with a wide spectrum of [...] Read more.
Visceral leishmaniasis (VL), often referred to as kala-azar, is quite rare in developed countries during pregnancy. Only few studies have evaluated its impact on perinatal outcome. It is caused primarily by Leishmania donovani or Leishmania infantum and presents with a wide spectrum of clinical manifestations from cutaneous ulcers to multisystem disease. Differential diagnosis is challenging as symptoms and signs are insidious, mimicking other diseases. Misdiagnosis can result in severe adverse perinatal outcomes, even maternal/neonatal death. Early treatment with liposomal amphotericin-B (LAmB) is currently the first choice with adequate effectiveness. We report a rare case of VL in a twin pregnancy with onset at the second trimester, presenting with periodic fever with rigors, right flank pain, and gradual dysregulation of all three cell lines. The positive rK39 enzyme-linked immunosorbent assay test confirmed the diagnosis. Treatment with LAmB resulted in clinical improvement within 48 h and in the delivery of two late-preterm healthy neonates with no symptoms or signs of vertical transmission. The one-year follow-up, of the mother and the neonates, was negative for recurrence. To our knowledge, this is the first reported case of VL in a twin pregnancy, and consequently treatment and perinatal outcome are of great importance. Full article
(This article belongs to the Special Issue Gynecologic and Obstetric Pathologies: From Birth to Menopause (Volume II))

Other

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17 pages, 3271 KiB  
Case Report
Intrauterine Contraceptive Device Migrated in the Urinary Tract: Case Report and Extensive Literature Review
by Valentin Nicolae Varlas, Andreea Ioana Meianu, Andra Ioana Rădoi, Irina Balescu, Nicolae Bacalbasa and Roxana Georgiana Varlas
J. Clin. Med. 2024, 13(14), 4233; https://doi.org/10.3390/jcm13144233 - 19 Jul 2024
Viewed by 420
Abstract
The migration or translocation of an intrauterine device (IUD) in the urinary tract is a rare event. Here, we present the case of a 55-year-old woman who accidentally discovered the ectopic presence of an IUD following a radiological examination for pelvic pain caused [...] Read more.
The migration or translocation of an intrauterine device (IUD) in the urinary tract is a rare event. Here, we present the case of a 55-year-old woman who accidentally discovered the ectopic presence of an IUD following a radiological examination for pelvic pain caused by a lumbar discopathy. Over the years, the patient had several IUDs inserted without being able to specify which one had migrated. The removal of the IUD was performed laparoscopically with the minimum resection of the bladder wall and the subsequent cystorrhaphy. The evolution of the patient was favorable. To better analyze these events, we conducted an all-time extensive electronic search of the PubMed database and identified 94 eligible articles, with a total of 115 cases. The literature analysis on the IUD migrations shows either the simultaneous existence of the second IUD or of a maximum number of up to two IUD insertions during the life of patients. Thus, in the presented case, we identified five IUD insertions over time, which explained the chronic inflammatory process by forming an important mass of adherents that included the urinary bladder, uterus, omentum, sigmoid colon, and abdominal wall. Therapeutic management must be adapted to each case depending on the intra/extravesical location of the migrated IUD evaluated by imaging. Full article
(This article belongs to the Special Issue Gynecologic and Obstetric Pathologies: From Birth to Menopause (Volume II))
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