Dear Colleagues,

Cells are the basic structural and functional units of tissues and all experience changes with physical growth. The study of the growth and physical development of children and young people is important from a clinical point of view. Understanding the variability and changes in the cells, tissues and organs of children is essential in order to compare these changes with the patterns considered normal for these ages and across sexes, as well as how these changes are modified by disease.

We invite authors to contribute to this Special Issue of the Journal of Clinical Medicine with articles focusing on any novel topic dealing with the pathogenesis, diagnosis, and treatment of cells, tissues and organs during children’s growth, and the factors that can influence their health and disease. While data from healthy individuals will be included, data from patients are particularly encouraged. New and comparative methodologies to understand the biology of these changes, as well as review articles, are welcomed. Potential topics include:

• Tissues homeostasis: proliferation and apoptosis
• Aging-related tissue-specific alterations
• Endocrinology of growth
• Somatic growth and sex differences
• Body composition during growth and development
• Connective tissue disorders
• Epithelial tissue disorders
• Muscle tissue disorders
• Nervous tissue disorders
• Adipose tissue remodeling in children
• Hematological differences in newborn and aging
• Emerging therapies
• Childhood cancer
• Risk and protective factors
• The interaction of biological and environmental factors
• Strategies for the clinical management of disorders
• Evaluation and implementation of new diagnostic techniques
• Clinical management of disease
• Biomarkers for clinical diagnosis

Dr. Fernando Capela e Silva
Dr. Ana Cristina Rodrigues Costa
Prof. Dr. Ana Rita Matias
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• tissues changes, children
• pathogenesis
• clinical features
• diagnostic criteria