Special Issue "Tissues Changes in Infancy, Childhood and Adolescence: Pathogenesis, Clinical Features, and Criteria for Diagnosis"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 950

Special Issue Editors

Dr. Fernando Capela e Silva
E-Mail Website
Guest Editor
1. Department of Medical and Health Sciences, School of Health and Human Development, University of Évora, 7000-671 Évora, Portugal
2. Mediterranean Institute for Agriculture, Environment and Development (MED), University of Évora, 7000-671 Évora, Portugal
Interests: biology of oral tissues; eating behavior and its effects on the health of people and populations; food, health and society and the “One Health” approach
Special Issues, Collections and Topics in MDPI journals
Dr. Ana Cristina Rodrigues Costa
E-Mail Website
Co-Guest Editor
Department of Medical and Health Sciences, School of Health and Human Development & ICT - Institute of Earth Sciences, University of Évora, Évora, Portugal
Interests: molecular basis of disease; biochemical toxicology and pharmacology; biomearkers development
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ana Rita Matias
E-Mail Website
Co-Guest Editor
Department of Sport and Health Sciences, School of Health and Human Development & Comprehensive Health Research Centre (CHRC), University of Évora, Évora, Portugal
Interests: typical development; atypical development; intervention
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cells are the basic structural and functional units of tissues and all experience changes with physical growth. The study of the growth and physical development of children and young people is important from a clinical point of view. Understanding the variability and changes in the cells, tissues and organs of children is essential in order to compare these changes with the patterns considered normal for these ages and across sexes, as well as how these changes are modified by disease.

We invite authors to contribute to this Special Issue of the Journal of Clinical Medicine with articles focusing on any novel topic dealing with the pathogenesis, diagnosis, and treatment of cells, tissues and organs during children’s growth, and the factors that can influence their health and disease. While data from healthy individuals will be included, data from patients are particularly encouraged. New and comparative methodologies to understand the biology of these changes, as well as review articles, are welcomed. Potential topics include:

  • Tissues homeostasis: proliferation and apoptosis
  • Aging-related tissue-specific alterations
  • Endocrinology of growth
  • Somatic growth and sex differences
  • Body composition during growth and development
  • Connective tissue disorders
  • Epithelial tissue disorders
  • Muscle tissue disorders
  • Nervous tissue disorders
  • Adipose tissue remodeling in children
  • Hematological differences in newborn and aging
  • Emerging therapies
  • Childhood cancer
  • Risk and protective factors
  • The interaction of biological and environmental factors
  • Strategies for the clinical management of disorders
  • Evaluation and implementation of new diagnostic techniques
  • Clinical management of disease
  • Biomarkers for clinical diagnosis

Dr. Fernando Capela e Silva
Dr. Ana Cristina Rodrigues Costa
Prof. Dr. Ana Rita Matias
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissues changes, children
  • pathogenesis
  • clinical features
  • diagnostic criteria

Published Papers (1 paper)

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Research

Article
Relationships between Body Weight Status and Serum Levels of Adipokine, Myokine and Bone Metabolism Parameters in Healthy Normal Weight and Thin Children
J. Clin. Med. 2022, 11(14), 4013; https://doi.org/10.3390/jcm11144013 - 11 Jul 2022
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Abstract
Optimal body weight and body composition for age are relevant to child development and healthy life. Changes in lean mass and fat mass as well as its distribution are associated with alterations in the secretion of myokines and adipokines by muscle and adipose [...] Read more.
Optimal body weight and body composition for age are relevant to child development and healthy life. Changes in lean mass and fat mass as well as its distribution are associated with alterations in the secretion of myokines and adipokines by muscle and adipose tissues. These factors are very important for bone health. The aim of the study was to assess serum leptin, adiponectin, resistin, visfatin and omentin as adipokines and myostatin and irisin as myokines with regard to their associations with bone parameters in healthy normal weight and thin children. We studied 81 healthy prepubertal children (aged 5 to 9 years) divided into three groups: group A—35 children with a BMI z-score between +1 and −1 SD; group B—36 children with a BMI z-score between −1 and −2 SD; and group C—10 thin children with a BMI z-score of <−2 SD. We observed significantly (p < 0.001) lower fat mass, fat/lean mass ratio and bone mineral density (BMD) across weight status with the lowest values in the group of thin children. We noticed significantly (p < 0.05) lower concentrations of 25-hydroxyvitamin D, resistin and high-molecular-weight (HMW) adiponectin but higher levels of myostatin as the BMI z-score deceased. We found that BMI and leptin levels were directly correlated with fat mass, lean mass, bone mineral content (BMC) and BMD. Resistin levels were negatively associated with lean mass, while visfatin concentrations were positively related to total BMD. In healthy prepubertal children there were differences in body composition and in bone mineral density across decreasing BMI status. We suggest that changes in serum myostatin and 25-hydroxyvitamin D levels may play a role in bone status of thin children. Moreover, significant relations between adipokines and bone parameters may confirm crosstalk between fat tissue and bone in these children. Full article
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