Molecular Mechanisms of Allergen-Specific Immunotherapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 323
Special Issue Editor
Interests: allergic disease; infectious diseases; upper respiratory tract
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment for respiratory allergies such as allergic rhinoconjunctivitis and allergic asthma. Given the increasing prevalence of these diseases in many regions of the world, AIT is therefore of fundamental health-economic importance.
In recent years, significant progress has been made in understanding the molecular basis of the disease. This particularly concerns the fields of genetic and bioinformatic research. This has enabled the development of approaches involving interactions with the cells involved in the allergic cascade, which raises hope for novel forms of treatment. This will be highlighted in this Special Edition. Suitable topics include but are not limited to the following: new findings regarding cytokines and other mediators; T-cell and B-cell mediated immunity; basophil cells; and receptors involved in the allergic reaction. Human genetic studies on the genes of the MHC and on inflammatory mediators, as well as on epigenetics and gene–environment interactions are also of interest.
Prof. Dr. Ralph Mösges
Guest Editor
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Keywords
- allergy, immunogenicity
- T-cells
- B-cells
- basophils
- zytokines
- receptors
- MHC genes
- HLA genes
- epigenetics
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