Recent Advances in the Pathogenesis and Therapeutic Strategies of Pituitary Tumors
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 11985
Special Issue Editors
2. Endocrine Unit, Humanitas Clinical and Research Center, Rozzano, MI, Italy
Interests: pituitary adenomas pathogenesis; neuroendocrine tumors pathogenesis and treatment
Special Issue Information
Dear colleagues,
Pituitary tumors, the third most common intracranial neoplasia, are mostly benign and well-differentiated; however, a sizable proportion of them (up to 45%) may show an invasive behaviour, resistance to conventional treatments, and a predisposition to progression/recurrence and malignancy. About 10% of invasive adenomas are "clinically aggressive", but only in exceptional cases (0.2%) do they metastasize, fulfilling the criteria for "carcinoma."
Although the term “pituitary adenomas” (PAs) remains consecrated by use, the WHO, in 2017, provided a detailed histopathological assessment to categorise PAs into different subtypes and to identify features that should be considered as a marker of aggressiveness.
Pinpointing the biomarkers of invasiveness and, perhaps, of malignancy, molecular biology can support the clinicopathological diagnosis into opening new strategies for early recognition and adequate post-operative management of potentially aggressive forms. Understanding the pathogenesis of pituitary adenomas will enable clinicians to correlate the pathologic and genetic features with clinical data, helping make decisions on the best management of these tumours.
In this Special Issue, we will publish reviews and original research that provide new insights into signalling pathways and biomarkers driving pituitary tumorigenesis, diagnosis, and therapeutic perspectives. Articles about aggressive pituitary tumours will be particularly welcome.
Prof. Dr. Lania Andrea Gerardo Antonio
Dr. Giampaolo Trivellin
Guest Editors
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Keywords
- pituitary adenoma
- morphofunctional classification
- pituitary tumorigenesis
- pituitary tumours biomarkers
- pituitary neurosurgery
- pituitary radiosurgery