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Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management
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Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (25 March 2023) | Viewed by 12479

Special Issue Editors

Dr. Amir Mari

E-Mail Website
Guest Editor
Gastroenterology and Hepatology Institute, Nazareth Hospital, Nazareth 16100, Israel
Interests: neurogastroenterology; motility disorders of the gastrointestinal tract; disorders of gut–brain interaction
Special Issues, Collections and Topics in MDPI journals
Dr. Edoardo V. Savarino

E-Mail Website
Guest Editor
Department of Surgery, Oncological and Gastrointestinal Science, University of Padova, 35121 Padova, Italy
Interests: neuro-gastroenterology; motility; high-resolution manometry; reflux monitoring; irritable bowel syndrome; inflammatory bowel diseases; eosinophilic gastrointestinal disorders; functional dyspepsia; postprandial distress syndrome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to announce the opening of the "Advances on Neurogastroenterology and Motility disorders: Physiology, Diagnostics and Management" Special Issue. In the last decade, we have witnessed important advancements in the field of neurogastroenterology, particularly in diagnostics such as the introduction of high-resolution esophageal and anorectal manometry, EndoFlip, pH monitoring with impedance, improvements in barium swallows methodology, MR proctography, motility capsules and other diagnostic tools. The improved diagnostic capability has improved our understanding of the diseases and therefore altered therapeutic approaches. This Special Issue focuses on recent advances on the diagnosis and management of various gastrointestinal disorders such as achalasia, GERD, gastroparesis, functional dyspepsia, IBS, abdominal bloating, constipation and fecal incontinence.

Dr. Amir Mari
Prof. Dr. Edoardo V. Savarino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • achalasia
  • GERD
  • high-resolution manometry
  • pH monitoring
  • gastroparesis
  • IBS
  • bloating
  • constipation
  • fecal incontinence
  • neuromodulation

Published Papers (5 papers)

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Research

9 pages, 1856 KiB  
Article
Correlation between Constipation Symptoms and Abdominal CT Imaging: A Cross-Sectional Pilot Study
by Mayuko Haraikawa, Tsutomu Takeda, Shotaro Oki, Mariko Hojo, Daisuke Asaoka, Tomoyo Iwano, Ryouta Uchida, Hisanori Utsunomiya, Nobuyuki Susuki, Daiki Abe, Atsushi Ikeda, Yoichi Akazawa, Kumiko Ueda, Hiroya Ueyama, Tomoyoshi Shibuya, Shuko Nojiri, Hidekazu Nagasawa, Masaru Suzuki, Ryohei Kuwatsuru and Akihito Nagahara
J. Clin. Med. 2023, 12(1), 341; https://doi.org/10.3390/jcm12010341 - 01 Jan 2023
Cited by 2 | Viewed by 3808
Abstract
Evaluation of chronic constipation is important, although it is often difficult to satisfactorily treat due to the complex interplay of factors. This study aimed to determine whether the volume of intraluminal contents and lateral diameter of the colon measured from computed tomography (CT) [...] Read more.
Evaluation of chronic constipation is important, although it is often difficult to satisfactorily treat due to the complex interplay of factors. This study aimed to determine whether the volume of intraluminal contents and lateral diameter of the colon measured from computed tomography (CT) images were correlated with the symptoms of chronic constipation and stool consistency. Consecutive patients who underwent the Constipation Scoring System (CSS), Bristol Stool Form Scale (BSFS) questionnaires and simple abdominal CT were selected retrospectively. The intestinal tract diameter at each site was measured, and the amounts of stool and gas in the intestinal tract were evaluated at five levels. Of the 149 study participants, 54 were males and 95 were females and their mean age was 72.1 years. In the right hemi-colon, CSS5 (Time) correlated significantly with gas volume (p < 0.01). In the left hemi-colon, stool volume correlated significantly with CSS2 (Difficulty), CSS3 (Completeness), CSS5 (Time) and CSS total (p < 0.05). The BSFS negatively correlated with gas volume and diameter in the right hemi-colon and with gas volume in the rectum (p < 0.05). CT findings including stool volume, gas volume and diameter correlated with some constipation symptoms and stool consistency. These findings may be useful in evaluating and treating constipation. Full article
(This article belongs to the Special Issue Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management)
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11 pages, 253 KiB  
Article
Comparison in Adherence to Treatment between Patients with Mild–Moderate and Severe Reflux Esophagitis: A Prospective Study
by Amir Mari, Wasef Na’amnih, Aiman Gahshan, Helal Saied Ahmad, Tawfik Khoury and Khitam Muhsen
J. Clin. Med. 2022, 11(11), 3196; https://doi.org/10.3390/jcm11113196 - 03 Jun 2022
Cited by 3 | Viewed by 1627
Abstract
Purpose: Gastro-esophageal reflux disease (GERD) is prevalent and causes erosive esophagitis (EE) with varying degrees of severity (A to D according to the Los Angeles Classification). Adherence to medical therapy is crucial for treatment success. We compared adherence to treatment recommendations between patients [...] Read more.
Purpose: Gastro-esophageal reflux disease (GERD) is prevalent and causes erosive esophagitis (EE) with varying degrees of severity (A to D according to the Los Angeles Classification). Adherence to medical therapy is crucial for treatment success. We compared adherence to treatment recommendations between patients with EE grades C/D and A/B. Methods: A follow-up study was conducted during 2019–2020 among GERD patients who underwent a diagnostic gastroscopy 1–4 years earlier. Telephone interviews were conducted with patients diagnosed with severe EE grades C/D (n = 99) and randomly selected patients with mild–moderate EE grades A/B (n = 50). Patients with grades A/B were classified as adherent if they took proton pump inhibitors (PPIs) for 2–3 months as recommended. Patients with grades C/D were classified as adherent if they took medications for a prolonged period (>6 months) and performed a follow-up endoscopy as recommended. Results: The mean age of the participants was 44.6 years (SD = 15.1). The mean duration of PPIs therapy in patients with EE grades A/B was 9.4 months (SD = 8.7). Fourteen (14.2%) patients with EE grades A/B were non-adherent to treatment, compared to 21 (40.8%) patients with EE grades of C/D: adjusted OR = 0.06; CI 95% 0.02–0.18, p < 0.001. Follow-up endoscopy was performed by 44% of EE–C/D patients. Unmarried patients compared to married ones were less adherent (adjusted OR = 0.23; 95% CI 0.08–0.69, p < 0.001). Conclusions: Patients with esophagitis (EE–A/B) were more adherent to medical therapy when compared to patients with more severe esophagitis (EE–C/D). Full article
(This article belongs to the Special Issue Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management)
9 pages, 762 KiB  
Article
Efficacy of Chenodeoxycholic Acid and Ursodeoxycholic Acid Treatments for Refractory Functional Dyspepsia
by Sung Ill Jang, Tae Hoon Lee, Seok Jeong, Chang-Il Kwon, Dong Hee Koh, Yoon Jae Kim, Hye Sun Lee, Min-Young Do, Jae Hee Cho and Dong Ki Lee
J. Clin. Med. 2022, 11(11), 3190; https://doi.org/10.3390/jcm11113190 - 02 Jun 2022
Cited by 1 | Viewed by 2136
Abstract
Refractory functional dyspepsia (RFD) is diagnosed when symptoms persist for at least 6 months despite at least two medical treatments. No consensus treatment guidelines exist. The implicated causes of functional biliary dyspepsia are a narrowed cystic duct, Sphincter of Oddi dysfunction, microlithiasis, and [...] Read more.
Refractory functional dyspepsia (RFD) is diagnosed when symptoms persist for at least 6 months despite at least two medical treatments. No consensus treatment guidelines exist. The implicated causes of functional biliary dyspepsia are a narrowed cystic duct, Sphincter of Oddi dysfunction, microlithiasis, and gallbladder dyskinesia. We investigated the treatment effects of litholytic agents. RFD patients were prospectively enrolled in six tertiary medical centers. All subjects took chenodeoxycholic and ursodeoxycholic acids (CNU) twice daily for 12 weeks. We monitored their medication adherence, laboratory results, and complications. The 7-point global symptom scale test scores were determined before and after treatment. Of the 52 patients who were prospectively screened, 37 were included in the final analysis. The mean age was 51.3 years: 14 were males, and 23 were females. Before treatment, the mean number and duration of symptoms were 2.4 and 48.2 months, and a mean of 3.3 FD-related drugs were taken. The mean CNU adherence was 95.3%. The mean global symptom scale score decreased from 5.6 pretreatment to 2.6 posttreatment. The symptom improvement rate was 94.6% (35 out of 37 patients). The only adverse event was mild diarrhea (10.8%) that was resolved after conservative management. Conclusions: CNU improved the symptoms of RFD patients who did not respond to conventional medications. Litholytic agents are good treatment options for patients with RFD and biliary dyspepsia secondary to biliary microlithiasis. Further prospective, large-scale mechanistic studies are warranted. Full article
(This article belongs to the Special Issue Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management)
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10 pages, 828 KiB  
Article
Epidemiology and Clinical Characteristics Based on the Rome III and IV Criteria of Japanese Patients with Functional Dyspepsia
by Sota Aono, Toshihiko Tomita, Katsuyuki Tozawa, Daisuke Morishita, Keisuke Nakai, Takuya Okugawa, Masashi Fukushima, Tadayuki Oshima, Hirokazu Fukui and Hiroto Miwa
J. Clin. Med. 2022, 11(9), 2342; https://doi.org/10.3390/jcm11092342 - 22 Apr 2022
Cited by 1 | Viewed by 1608
Abstract
The subtypes of functional dyspepsia (FD) differ depending on whether the Rome III criteria or the Rome IV criteria are used. We investigated the ability to diagnose FD patients using the Rome III and IV criteria. The subtypes of FD were evaluated using [...] Read more.
The subtypes of functional dyspepsia (FD) differ depending on whether the Rome III criteria or the Rome IV criteria are used. We investigated the ability to diagnose FD patients using the Rome III and IV criteria. The subtypes of FD were evaluated using the Rome questionnaire. The Gastrointestinal Symptom Rating Score, health-related quality of life (HR-QOL; SF-8), and psychological scores (HADS, STAI) were evaluated. The questionnaire was collected from a total of 205 patients, and 54.1% were FD patients. The ratio of FD patients under the Rome III criteria was 19% for epigastric pain syndrome (EPS), 38% for postprandial distress syndrome (PDS), and 43% for an overlap of EPS and PDS, but under the Rome IV criteria overlap decreased to 17% and PDS increased to 64%. Patients whose subtype changed from overlap under the Rome III criteria to PDS under the Rome IV criteria were compared with PDS patients whose subtype did not change between the Rome III and IV criteria. The comparison showed that the former had significantly lower early satiation rates and significantly higher acid reflux and abdominal pain scores, demonstrating that EPS symptoms due to acid reflux after meals were clearly present. As a result of changing from the Rome III criteria to the Rome IV criteria, the number of overlap patients decreased, and the number of PDS patients increased. Full article
(This article belongs to the Special Issue Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management)
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11 pages, 1672 KiB  
Article
Evaluation of QOL in Patients with Dyspeptic Symptoms Who Meet or Do Not Meet Rome IV Criteria
by Masatoshi Mieno, Toshihiko Tomita, Sota Aono, Katsuyuki Tozawa, Keisuke Nakai, Takuya Okugawa, Masashi Fukushima, Tadayuki Oshima, Hirokazu Fukui and Hiroto Miwa
J. Clin. Med. 2022, 11(1), 21; https://doi.org/10.3390/jcm11010021 - 22 Dec 2021
Cited by 1 | Viewed by 2146
Abstract
Health related quality of life (HR-QOL) of functional dyspepsia (FD) patients is impaired. However, the QOL of such patients has not been fully examined. Accordingly, we examined the QOL of Rome IV defined FD, endoscopic negative dyspeptic patients who do not meet the [...] Read more.
Health related quality of life (HR-QOL) of functional dyspepsia (FD) patients is impaired. However, the QOL of such patients has not been fully examined. Accordingly, we examined the QOL of Rome IV defined FD, endoscopic negative dyspeptic patients who do not meet the criteria, (non-FD patients) and healthy subjects, and investigated the factors that influence HR-QOL. This was a multicenter, prospective, observational study. Two hundred thirty-five patients (126 FD, 87 non-FD) and 111 healthy subjects were investigated, and non-FD patients were subdivided into three groups: 17 patients failing to meet only the disease duration criterion (Group A), 53 patients failing to meet only disease frequency criterion (Group B) and 17 patients failing to meet both the disease duration and frequency criteria (Group C). They completed a questionnaire survey regarding gastrointestinal symptoms (GSRS), QOL and psychological factors, which were compared among three groups. The total GSRS score was significantly higher in FD patients than non-FD patients (p = 0.012), which was higher than the healthy subjects (p < 0.0001). Furthermore, the total GSRS score of FD patients was comparable to that of Group A (p = 0.885), which was significantly higher than that of the Group B and C (p = 0.028, p = 0.014, respectively). HR-QOL is more impaired in FD patients than non-FD patients, which was significantly lower than the healthy subjects. That GSRS score in FD and Group A was comparable suggesting that an increased frequency of symptoms may have impact on the impairment of patient’s QOL. Full article
(This article belongs to the Special Issue Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management)
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