Management of Gastrointestinal Disorders Related to Infectious Diseases and Medications

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 938

Special Issue Editors

1. Gastroenterology Unit, Nazareth EMMS Hospital, Nazareth, Israel
2. The Azrieli Faculty of Medicine, Bar Ilan University, Ramat Gan, Israel
Interests: esophageal disease; neurogastroenterology; esophageal diagnostics; gastrointestinal conditions; infectious diseases
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Guest Editor Assistant
1. Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Hadera, Israel
2. The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
Interests: endoscopic evaluation of GI disorders; diagnostic and therapeutic endoscopy; hepatology, particularly viral hepatitis and MASLD
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Special Issue Information

Dear Colleagues,

Gastrointestinal (GI) symptoms and conditions, including nausea, vomiting, diarrhea, abdominal pain, bleeding and changes in bowel habits, are prevalent manifestations in patients with infectious diseases and those undergoing various pharmacological treatments. These symptoms significantly impact patient quality of life and present frequent challenges in primary care, internal medicine, and gastroenterology settings. Despite their common occurrence, the management of GI symptoms related to infections and medications remains underexplored in the medical literature. This Special Issue aims to address this gap, seeking original research and comprehensive reviews that explore the pathophysiology, diagnostic approaches, and therapeutic strategies for GI symptoms associated with infectious agents and pharmacological interventions. We encourage submissions that investigate the prevalence and burden of these symptoms in various populations, assess the efficacy of current management protocols, and identify areas requiring further inquiry. By deepening the understanding of these multifaceted interactions, this issue aspires to inform clinical practices and advance patient care strategies to effective manage GI symptoms linked to infections and medications.

Dr. Amir Mari
Guest Editor

Dr. Fadi Abu Baker
Guest Editor Assistant

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Keywords

  • gastrointestinal symptoms
  • drug-related gastrointestinal disorders
  • gastrointestinal infections
  • diarrhea
  • infectious
  • intestinal microbiota
  • foodborne diseases
  • patient-centered outcomes

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Published Papers (1 paper)

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Research

11 pages, 427 KiB  
Article
Predictive Factors Associated with Inappropriate Intravenous Proton Pump Inhibitors Use in Hospitalized Patients: A Case-Control Study
by Niveen Khoury, David Stepensky, Naim Abu Freha, Mahmud Mahamid, Tawfik Khoury and Amir Mari
Medicina 2025, 61(1), 10; https://doi.org/10.3390/medicina61010010 - 25 Dec 2024
Viewed by 742
Abstract
Background and Objectives: Proton Pump Inhibitors (PPIs) are the most effective agents for treating acid-related gastrointestinal disorders. The prescription of an intravenous (IV) formulation of PPIs has increased dramatically. The aims of this study were to assess the appropriateness of IV PPI [...] Read more.
Background and Objectives: Proton Pump Inhibitors (PPIs) are the most effective agents for treating acid-related gastrointestinal disorders. The prescription of an intravenous (IV) formulation of PPIs has increased dramatically. The aims of this study were to assess the appropriateness of IV PPI use and to define the risk factors and outcomes associated with its inappropriate use. Materials and Methods: A case-control retrospective study included all the hospitalized patients who received IV PPIs was conducted. Patient health records were reviewed, data were collected covering the period of the individual patients’ admission to the hospital until discharge or death, and over the 3-month post-discharge period. The appropriateness of the IV PPI use and the resulting clinical outcomes were analyzed. Results: Overall, 540 patients were analyzed. Among them, 130/540 (24%) had inappropriate PPI use in terms of indication, dosage, and duration of treatment vs. 410 patients who had appropriate indications. Two parameters were associated with inappropriate use: congestive heart failure (OR 1.77; p = 0.02) and prescription of IV PPIs by surgeons vs. internists (OR 1.53; p = 0.05). Conclusions: Inappropriate IV PPI use is still common in daily clinical practice. Significant predictors of inappropriate use were the presence of congestive heart failure, elderly age, current use of anticoagulants and antithromotics, and the cases managed by surgeons, naturally due to suspected upper gastrointestinal bleedings. Full article
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