Epidemiology and Treatment of Metastatic Lesions Around the Elbow: A Systematic Review
Abstract
1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Study Selection
2.3. Data Extraction/Analysis
2.4. Quality Assessment
3. Results
3.1. Search and Literature Selection
3.2. Study Characteristics
3.3. Demographic Characteristics
3.4. Metastases
3.5. Treatment
- -
- Bone allograft stabilized by a reamed intramedullary nail and a short plate in order to avoid rotations was used after partial distal humerus excision in one patient (25%);
- -
- Non-vascularized autologous fibular graft after proximal ulna excision in one patient (25%);
- -
- Radial neck to humerus trochlea transposition after proximal ulna excision in one patient (25%);
- -
- Bone cement and osteostimulative bone substitute to fill the bone defect after ulnar metastasis resection in one patient (25%).
4. Discussion
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Authors | Year of Publication | Type of Article | mCMS | n° Patients | Gender | Age at Diagnosis (Years) | |
---|---|---|---|---|---|---|---|
Male | Female | ||||||
Henrichs MP et al. [3] | 2018 | Retrospective Study | 55 | 2 | x | x | 69 |
Casadei R et al. [15] | 2018 | Retrospective Study | 45 | 9 | 7 | 2 | 64 |
West W 3rd et al. [20] | 2024 | Retrospective Study | 35 | 23 | x | x | 64 |
Liao GJ et al. [21] | 2023 | Case Report | 32 | 1 | 1 | - | 56 |
Scherer S et al. [22] | 2023 | Case Report | 30 | 1 | 1 | - | 6 |
Aljuhani WS et al. [23] | 2023 | Case Report | 27 | 1 | 1 | - | 60 |
Gamage S et al. [24] | 2023 | Case Report | 12 | 1 | - | 1 | 68 |
Boddu D et al. [25] | 2021 | Case Report | 37 | 1 | 1 | - | 7 |
Luo Z et al. [26] | 2021 | Case Report | 17 | 1 | 1 | - | 68 |
Bianchi A et al. [27] | 2020 | Case Report | 22 | 1 | 1 | - | 80 |
Kord A et al. [28] | 2020 | Case Report | 10 | 1 | - | 1 | 52 |
Vempuluru VS et al. [29] | 2020 | Case Report | 25 | 1 | 1 | - | 0.9 |
Cai L et al. [30] | 2020 | Case Report | 22 | 1 | 1 | - | 62 |
Casadei R et al. [31] | 2016 | Retrospective Study | 52 | 17 | x | x | 58.5 |
Megas P et al. [32] | 2017 | Case Report | 18 | 1 | 1 | - | 50 |
Devdas SK et al. [33] | 2016 | Case Report | 20 | 1 | - | 1 | 52 |
Subhadrabandhu S et al. [34] | 2015 | Retrospective Study | 55 | 1 | 1 | - | 65 |
Pruksakorn D et al. [35] | 2014 | Prospective Cohort Study | 59 | 3 | 1 | 2 | X |
Tunio MA et al. [36] | 2013 | Case Report | 22 | 1 | - | 1 | 73 |
Sørensen MS et al. [37] | 2013 | Cross-Sectional Study | 43 | 5 | x | x | 64 |
Wedin R et al. [38] | 2011 | Retrospective Study | 56 | 15 | x | x | 67 |
Culleton S et al. [39] | 2008 | Case Report | 23 | 1 | 1 | - | 51 |
Hanna SA et al. [40] | 2007 | Retrospective Study | 54 | 6 | 4 | 2 | 60 |
Rolf et al. [41] | 2004 | Case Report | 37 | 4 | 4 | - | 65.2 |
Ansari et al. [42] | 2003 | Case Report | 13 | 1 | 1 | - | 60 |
Fernández-Valencia JA et al. [43] | 2002 | Case Report | 33 | 1 | - | 1 | 48 |
Durusu et al. [44] | 2002 | Case Report | 13 | 1 | - | 1 | 38 |
Peterson JJ et al. [45] | 1999 | Case Report | 13 | 1 | 1 | - | 79 |
31 | 103 | 29 | 12 | 55 |
Authors | n° Metastasis | Localization | Primary Tumor | ||||||
---|---|---|---|---|---|---|---|---|---|
Distal Humerus | Proximal Radius | Proximal Ulna | “Elbow” | Breast | Lung | Kidney | Other | ||
Henrichs MP et al. [3] | 2 | 2 | - | - | - | - | - | 2 | - |
Casadei R et al. [13] | 9 | 9 | - | - | - | - | - | 9 | - |
West W 3rd et al. [18] | 23 | 23 | - | - | - | x | x | x | x |
Liao GJ et al. [19] | 1 | 1 | - | - | - | - | - | 1 | - |
Scherer S et al. [20] | 1 | - | - | 1 | - | - | - | - | Neuroblastoma (1) |
Aljuhani WS et al. [21] | 1 | - | - | 1 | - | - | - | - | Colon (1) |
Gamage S et al. [22] | 1 | - | 1 | - | - | - | 1 | - | - |
Boddu D et al. [23] | 1 | - | - | 1 | - | - | - | - | Retinoblastoma (1) |
Luo Z et al. [24] | 1 | - | - | - | 1 | - | 1 | - | - |
Bianchi A et al. [25] | 1 | 1 | - | - | - | - | - | - | Colon (1) |
Kord A et al. [26] | 1 | - | - | 1 | - | - | - | - | Uterus (1) |
Vempuluru VS et al. [27] | 1 | - | - | 1 | - | - | - | - | Retinoblastoma (1) |
Cai L et al. [28] | 1 | - | - | 1 | - | - | 1 | - | - |
Casadei R et al. [29] | 17 | 17 | - | - | - | 5 | 2 | 6 | Osteosarcoma (1), Bladder (1), Liver (1), Thyroid (1) |
Megas P et al. [30] | 1 | - | - | 1 | - | - | - | 1 | - |
Devdas SK et al. [31] | 1 | 1 | - | - | - | - | - | - | Uterus (1) |
Subhadrabandhu S et al. [32] | 1 | - | 1 | - | - | - | - | 1 | - |
Pruksakorn D et al. [33] | 3 | 2 | - | 1 | - | 2 | 1 | - | - |
Tunio MA et al. [34] | 1 | 1 | - | - | - | - | - | - | Gallbladder (1) |
Sørensen MS et al. [35] | 5 | 5 | - | - | - | x | x | x | x |
Wedin R et al. [36] | 15 | 15 | - | - | - | x | x | x | x |
Culleton S et al. [37] | 1 | - | - | 1 | - | - | - | 1 | - |
Hanna SA et al. [38] | 6 | 6 | - | - | - | 1 | - | 3 | Melanoma (1), Larynx (1) |
Rolf et al. [39] | 4 | 3 | - | 1 | - | - | - | 4 | - |
Ansari et al. [40] | 1 | - | 1 | - | - | - | - | - | Prostate (1) |
Fernández-Valencia JA et al. [41] | 1 | 1 | - | - | - | 1 | - | - | - |
Durusu et al. [42] | 1 | - | 1 | - | - | - | - | - | Neuroblastoma (1) |
Peterson JJ et al. [43] | 1 | 1 | - | - | - | - | - | - | Squamous Skin (1) |
103 | 88 | 4 | 10 | 1 | 9 | 6 | 28 | 17 |
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De Fazio, A.; Mazzella, G.G.; Miele, G.; Bocchi, M.B.; El Ezzo, O.; Capece, G.; Maccauro, G.; Vitiello, R. Epidemiology and Treatment of Metastatic Lesions Around the Elbow: A Systematic Review. J. Clin. Med. 2025, 14, 6297. https://doi.org/10.3390/jcm14176297
De Fazio A, Mazzella GG, Miele G, Bocchi MB, El Ezzo O, Capece G, Maccauro G, Vitiello R. Epidemiology and Treatment of Metastatic Lesions Around the Elbow: A Systematic Review. Journal of Clinical Medicine. 2025; 14(17):6297. https://doi.org/10.3390/jcm14176297
Chicago/Turabian StyleDe Fazio, Andrea, Giovan Giuseppe Mazzella, Guglielmo Miele, Maria Beatrice Bocchi, Omar El Ezzo, Giacomo Capece, Giulio Maccauro, and Raffaele Vitiello. 2025. "Epidemiology and Treatment of Metastatic Lesions Around the Elbow: A Systematic Review" Journal of Clinical Medicine 14, no. 17: 6297. https://doi.org/10.3390/jcm14176297
APA StyleDe Fazio, A., Mazzella, G. G., Miele, G., Bocchi, M. B., El Ezzo, O., Capece, G., Maccauro, G., & Vitiello, R. (2025). Epidemiology and Treatment of Metastatic Lesions Around the Elbow: A Systematic Review. Journal of Clinical Medicine, 14(17), 6297. https://doi.org/10.3390/jcm14176297