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Review Special Issue Series: Paradigm, Advances, and Future Directions in Oral Medicine

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: closed (25 December 2024) | Viewed by 7624

Special Issue Editor

Prof. Dr. Pia Lopez-Jornet

E-Mail Website
Guest Editor
Oral Medicine in the Department of Stomatology, Faculty of Dentistry, University of Murcia, 30008 Murcia, Spain
Interests: oral mucosa; oral lichen planus; leukoplakia; aphta; oral potentially malignant disorders (OPMDs); xerostomia; oral pain
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advances in the field of oral medicine are remarkable. However, research is still needed in many areas of oral medicine, such as potentially malignant disorders, dermatologic diseases of the oral cavity and orofacial pain.

The development and advancement of diagnostic techniques, many of them minimally invasive, and treatments have led to improved diagnoses and quality of life.

In this Special Issue, we invite authors to present papers on clinical advances in oral medicine diagnostics and treatment.

Prof. Dr. Pia Lopez-Jornet
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral medicine
  • oral potentially malignant disorders
  • leukoplakia
  • oral lichen planus
  • orofacial pain
  • biopsy and liquid biopsy
  • biomarkers

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Published Papers (4 papers)

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13 pages, 1699 KiB  
Review
Chemotherapy with Alkylating Agents and Dental Anomalies in Children: A Systematic Review
by Patrizia Gallenzi, Angela Malatesta, Edoardo Staderini and Federica Guglielmi
J. Clin. Med. 2025, 14(3), 1030; https://doi.org/10.3390/jcm14031030 - 6 Feb 2025
Viewed by 772
Abstract
The aim of the systematic review is to analyze the type and the prevalence of dental side effects among cancer survivors treated with alkylating agents (AAs) during pediatric age. Moreover, the study aimed to investigate the association between the development of dental anomalies [...] Read more.
The aim of the systematic review is to analyze the type and the prevalence of dental side effects among cancer survivors treated with alkylating agents (AAs) during pediatric age. Moreover, the study aimed to investigate the association between the development of dental anomalies and the drug used or the tumor type. Four databases MEDLINE-PubMed, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from January 2024 to March 2024. All articles published up to March 2024 were evaluated. After removing duplicates, data extraction and risk of bias assessment using the Newcastle–Ottawa score were made. A summary of the overall strength of evidence available was performed using the “Grading of Recommendations Assessment, Development and Evaluation” (GRADE). Data were summarized using descriptive analysis as mean differences ± standard deviation or relative risks. Out of 2678 studies, the search identified five studies enrolled for the qualitative analysis of the data. Among 257 survivors, 155 (60.3%) reported: microdontia, agenesia, root shortening, enamel defects, and taurodontism. Microdontia occurred more frequently with other drugs compared to AAs. In conclusion, children treated with AAs showed microdontia (36.0%), root shortening (26.9%), and agenesis (23.5%). Secondly, the occurrence of dental anomalies was unaffected by drug treatment; thirdly, microdontia was the most frequent dental anomaly observed in both solid and lymphoproliferative tumors. This review was performed in accordance with the PRISMA guidelines. PROSPERO registration number CRD42023494560. Full article
(This article belongs to the Special Issue Review Special Issue Series: Paradigm, Advances, and Future Directions in Oral Medicine)
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13 pages, 7598 KiB  
Review
Peripheral Ameloblastoma: A Case Report and Review of Literature
by Sem Decani, Martina Quatrale, Veronica Caria, Laura Moneghini and Elena Maria Varoni
J. Clin. Med. 2024, 13(22), 6714; https://doi.org/10.3390/jcm13226714 - 8 Nov 2024
Cited by 1 | Viewed by 1691
Abstract
Peripheral ameloblastoma (PA) is a rare benign tumor that can occur mostly in the mandibular gingiva of the premolar area, originating from the residual odontogenic epithelium. The patient is usually asymptomatic and the lesion can be an occasional finding during routine intraoral examination. [...] Read more.
Peripheral ameloblastoma (PA) is a rare benign tumor that can occur mostly in the mandibular gingiva of the premolar area, originating from the residual odontogenic epithelium. The patient is usually asymptomatic and the lesion can be an occasional finding during routine intraoral examination. Due to the lack of clinical and radiographic pathognomonic features, the diagnosis is based on histopathological analysis, associated with 3D computed tomography (CT) imaging. Here, we report the case of a middle-aged man showing an asymptomatic, sessile, normochromic papillomatous mass of the lingual alveolar mucosa, in correspondence of tooth 4.4, which was histologically diagnosed as peripheral ameloblastoma. After the complete excision of the lesion, there were no recurrence and no symptoms during the 3-year follow-up. The treatment of choice for PA is a conservative surgical excision, which usually results in a good prognosis, together with a long-term follow-up, necessary to intercept possible recurrence or, more rarely, malignant transformation. Full article
(This article belongs to the Special Issue Review Special Issue Series: Paradigm, Advances, and Future Directions in Oral Medicine)
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16 pages, 548 KiB  
Systematic Review
Impact of COVID-19 Disease on the Development of Osteomyelitis of Jaws: A Systematic Review
by Emmanouil Vardas, Daniela Adamo, Federica Canfora, Maria Kouri, Konstantina Delli, Michele Davide Mignogna and Nikolaos Nikitakis
J. Clin. Med. 2024, 13(15), 4290; https://doi.org/10.3390/jcm13154290 - 23 Jul 2024
Cited by 2 | Viewed by 1988
Abstract
Background/Objectives: Osteomyelitis is characterized by an inflammatory process affecting both bone and bone marrow, leading to cell death and the formation of bone sequestrum. Recent literature from the past five years has documented instances of osteomyelitis following infections of SARS-CoV-2. This systematic review [...] Read more.
Background/Objectives: Osteomyelitis is characterized by an inflammatory process affecting both bone and bone marrow, leading to cell death and the formation of bone sequestrum. Recent literature from the past five years has documented instances of osteomyelitis following infections of SARS-CoV-2. This systematic review explores the link between osteomyelitis of the jaw (OMJ) and COVID-19 infections. Methods: This review adhered to the PRISMA guidelines, systematically analyzing literature from 2020 to 2024 sourced from databases including Medline, Embase, Scopus, and Web of Science. PROSPERO ID: CRD42024526257. Results: The review selected 42 articles, detailing 201 cases of osteomyelitis of the jaw related to COVID-19 (COMJ). The demographic breakdown included 195 male (74.4%) and 67 female patients (25.6%), with a median age of 52.7 years, ranging from 24 to 71 years. A significant portion of COMJ patients (41.5%) were hospitalized due to COVID-19, and 58.5% received corticosteroid therapy. Diabetes mellitus was a common comorbidity among COMJ patients (65.1%). Most cases involved maxilla (182 cases; 90.5%), with nearly half showing sinus involvement (49.4%). The mandible was affected in 19 cases (9.5%). Mucormycosis and aspergillosis emerged as the predominant fungal infections, identified in 103 (51.2%) and 50 (24.9%) cases, respectively. Conclusions: Individuals with pre-existing health conditions such as diabetes mellitus who have been treated for COVID-19 are at an increased risk of developing OMJ, particularly maxillary fungal osteomyelitis. COMJ poses a significant diagnostic and therapeutic challenge for dental and maxillofacial professionals, who are often the first to encounter these cases. Full article
(This article belongs to the Special Issue Review Special Issue Series: Paradigm, Advances, and Future Directions in Oral Medicine)
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14 pages, 991 KiB  
Systematic Review
Effect of Photobiomodulation on Salivary Cytokines in Head and Neck Cancer Patients with Oral Mucositis: A Systematic Review
by Marwa Khalil, Omar Hamadah, Maher Saifo, Hasan Khalil, Mowaffak Adi, Faris Alabeedi and Omar Kujan
J. Clin. Med. 2024, 13(10), 2822; https://doi.org/10.3390/jcm13102822 - 10 May 2024
Cited by 4 | Viewed by 2215
Abstract
Background: Oral mucositis is a common and distressing side effect of head and neck oncology treatment. Photobiomodulation therapy can be utilized to prevent and treat oral mucositis. Its impact on salivary cytokines has yet to be thoroughly investigated. This is the first systematic [...] Read more.
Background: Oral mucositis is a common and distressing side effect of head and neck oncology treatment. Photobiomodulation therapy can be utilized to prevent and treat oral mucositis. Its impact on salivary cytokines has yet to be thoroughly investigated. This is the first systematic review aiming to evaluate the effect of photobiomodulation on salivary cytokines in patients undergoing anticancer treatment. Methods: Numerous data resources, from the Web of Science, Embase, ScienceDirect, PubMed, Cochrane Library, and Scopus were sought. Articles published up until February 2024 were included if they met the following inclusion criteria: clinical trials reporting the effect on salivary cytokines in patients undergoing anticancer therapy. The methodological quality was assessed using several appraisal tools. Results: Four studies were deemed eligible for inclusion. All the studies were conducted in Brazil and used an InGaAlP diode laser with a wavelength of 660 nm. The included studies had a relatively low risk of bias. The head and neck cancer patients’ salivary cytokines that were assessed by the studies, along with photobiomodulation therapy, included IL-12p70, TNF-α, IL-6, IL-8, IL-10, CXCL8, and IL-1β. The results varied among the studies. Conclusions: Our results show that photobiomodulation demonstrated positive results for reducing the severity of OM in all the included studies. Among the examined salivary cytokines, IL-6 is the most relevant cytokine for oral mucositis development and severity. A variation in the cytokine levels between the studies was noted due to differences in the type of anticancer treatment and saliva sampling. Full article
(This article belongs to the Special Issue Review Special Issue Series: Paradigm, Advances, and Future Directions in Oral Medicine)
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